Cushing's syndrome in the elderly: data from the European Registry on Cushing's syndrome

Objective To evaluate whether age-related differences exist in clinical characteristics, diagnostic approach, and management strategies in patients with Cushing's syndrome (CS) included in the European Registry on Cushing's Syndrome (ERCUSYN). Design Cohort study. Methods We analyzed 1791...

Descripción completa

Detalles Bibliográficos
Autores: Amodru, V, Ferriere, A, Tabarin, A, Castinetti, F, Tsagarakis, S, Toth, M, Feelders, RA, Webb, SM, Reincke, M, Netea-Maier, R, Kastelan, D, Elenkova, A, Maiter, D, Ragnarsson, O, Santos, A, Valass, E, ERCUSYN Study Grp
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p16238
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16238
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85159250173&doi=10.1093%2fejendo%2flvad008&partnerID=40&md5=b860583a1586bc13f9f9381c757e58cb
Access Level:acceso abierto
Palabra clave:Cushing's syndrome
aging
ERCUSYN
elderly patients
id ES_49f496fca4091ee7690994b2be8ef2d4
oai_identifier_str oai:iibsantpau.fundanetsuite.com:p16238
network_acronym_str ES
network_name_str España
repository_id_str
spelling Cushing's syndrome in the elderly: data from the European Registry on Cushing's syndromeAmodru, VFerriere, ATabarin, ACastinetti, FTsagarakis, SToth, MFeelders, RAWebb, SMReincke, MNetea-Maier, RKastelan, DElenkova, AMaiter, DRagnarsson, OSantos, AValass, EERCUSYN Study GrpCushing's syndromeagingERCUSYNelderly patientsObjective To evaluate whether age-related differences exist in clinical characteristics, diagnostic approach, and management strategies in patients with Cushing's syndrome (CS) included in the European Registry on Cushing's Syndrome (ERCUSYN). Design Cohort study. Methods We analyzed 1791 patients with CS, of whom 1234 (69%) had pituitary-dependent CS (PIT-CS), 450 (25%) adrenal-dependent CS (ADR-CS), and 107 (6%) had an ectopic source (ECT-CS). According to the WHO criteria, 1616 patients (90.2%) were classified as younger (<65 years old) and 175 (9.8%) as older (>= 65 years old). Results Older patients were more frequently males and had a lower Body Mass Index (BMI) and waist circumference when compared with the younger. Older patients also had a lower prevalence of skin alterations, depression, hair loss, hirsutism, and reduced libido, but a higher prevalence of muscle weakness, diabetes, hypertension, cardiovascular disease, venous thromboembolism, and bone fractures than younger patients, regardless of sex (P < .01 for all comparisons). Measurement of urinary free cortisol supported the diagnosis of CS less frequently in older patients when compared with the younger (P < .05). An extrasellar macroadenoma (macrocorticotropinoma with extrasellar extension) was more common in older PIT-CS patients than in the younger (P < .01). Older PIT-CS patients more frequently received cortisol-lowering medications and radiotherapy as a first-line treatment, whereas surgery was the preferred approach in the younger (P < .01 for all comparisons). When transsphenoidal surgery was performed, the remission rate was lower in the elderly when compared with their younger counterpart (P < .05). Conclusions Older CS patients lack several typical symptoms of hypercortisolism, present with more comorbidities regardless of sex, and are more often conservatively treated.BIOSCIENTIFICA LTD2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16238https://www.scopus.com/inward/record.uri?eid=2-s2.0-85159250173&doi=10.1093%2fejendo%2flvad008&partnerID=40&md5=b860583a1586bc13f9f9381c757e58cbEUROPEAN JOURNAL OF ENDOCRINOLOGYISSN: 08044643ISSNe: 1479683Xreponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p162382026-06-14T12:41:47Z
dc.title.none.fl_str_mv Cushing's syndrome in the elderly: data from the European Registry on Cushing's syndrome
title Cushing's syndrome in the elderly: data from the European Registry on Cushing's syndrome
spellingShingle Cushing's syndrome in the elderly: data from the European Registry on Cushing's syndrome
Amodru, V
Cushing's syndrome
aging
ERCUSYN
elderly patients
title_short Cushing's syndrome in the elderly: data from the European Registry on Cushing's syndrome
title_full Cushing's syndrome in the elderly: data from the European Registry on Cushing's syndrome
title_fullStr Cushing's syndrome in the elderly: data from the European Registry on Cushing's syndrome
title_full_unstemmed Cushing's syndrome in the elderly: data from the European Registry on Cushing's syndrome
title_sort Cushing's syndrome in the elderly: data from the European Registry on Cushing's syndrome
dc.creator.none.fl_str_mv Amodru, V
Ferriere, A
Tabarin, A
Castinetti, F
Tsagarakis, S
Toth, M
Feelders, RA
Webb, SM
Reincke, M
Netea-Maier, R
Kastelan, D
Elenkova, A
Maiter, D
Ragnarsson, O
Santos, A
Valass, E
ERCUSYN Study Grp
author Amodru, V
author_facet Amodru, V
Ferriere, A
Tabarin, A
Castinetti, F
Tsagarakis, S
Toth, M
Feelders, RA
Webb, SM
Reincke, M
Netea-Maier, R
Kastelan, D
Elenkova, A
Maiter, D
Ragnarsson, O
Santos, A
Valass, E
ERCUSYN Study Grp
author_role author
author2 Ferriere, A
Tabarin, A
Castinetti, F
Tsagarakis, S
Toth, M
Feelders, RA
Webb, SM
Reincke, M
Netea-Maier, R
Kastelan, D
Elenkova, A
Maiter, D
Ragnarsson, O
Santos, A
Valass, E
ERCUSYN Study Grp
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cushing's syndrome
aging
ERCUSYN
elderly patients
topic Cushing's syndrome
aging
ERCUSYN
elderly patients
description Objective To evaluate whether age-related differences exist in clinical characteristics, diagnostic approach, and management strategies in patients with Cushing's syndrome (CS) included in the European Registry on Cushing's Syndrome (ERCUSYN). Design Cohort study. Methods We analyzed 1791 patients with CS, of whom 1234 (69%) had pituitary-dependent CS (PIT-CS), 450 (25%) adrenal-dependent CS (ADR-CS), and 107 (6%) had an ectopic source (ECT-CS). According to the WHO criteria, 1616 patients (90.2%) were classified as younger (<65 years old) and 175 (9.8%) as older (>= 65 years old). Results Older patients were more frequently males and had a lower Body Mass Index (BMI) and waist circumference when compared with the younger. Older patients also had a lower prevalence of skin alterations, depression, hair loss, hirsutism, and reduced libido, but a higher prevalence of muscle weakness, diabetes, hypertension, cardiovascular disease, venous thromboembolism, and bone fractures than younger patients, regardless of sex (P < .01 for all comparisons). Measurement of urinary free cortisol supported the diagnosis of CS less frequently in older patients when compared with the younger (P < .05). An extrasellar macroadenoma (macrocorticotropinoma with extrasellar extension) was more common in older PIT-CS patients than in the younger (P < .01). Older PIT-CS patients more frequently received cortisol-lowering medications and radiotherapy as a first-line treatment, whereas surgery was the preferred approach in the younger (P < .01 for all comparisons). When transsphenoidal surgery was performed, the remission rate was lower in the elderly when compared with their younger counterpart (P < .05). Conclusions Older CS patients lack several typical symptoms of hypercortisolism, present with more comorbidities regardless of sex, and are more often conservatively treated.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16238
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85159250173&doi=10.1093%2fejendo%2flvad008&partnerID=40&md5=b860583a1586bc13f9f9381c757e58cb
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16238
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85159250173&doi=10.1093%2fejendo%2flvad008&partnerID=40&md5=b860583a1586bc13f9f9381c757e58cb
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BIOSCIENTIFICA LTD
publisher.none.fl_str_mv BIOSCIENTIFICA LTD
dc.source.none.fl_str_mv EUROPEAN JOURNAL OF ENDOCRINOLOGY
ISSN: 08044643
ISSNe: 1479683X
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869407456115818496
score 15,812429

Similares en LA Referencia