TSPAN1: A Novel Protein Involved in Head and Neck Squamous Cell Carcinoma Chemoresistance

Therapy resistance in head and neck squamous cell carcinoma (HNSCC) patients is the main obstacle to achieve more e ective treatments that improve survival and quality of life of these patients. Therefore, it is of vital importance to unravel the molecular and cellular mechanisms by which tumor cell...

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Detalles Bibliográficos
Autores: García Mayea, Yoelsis, Mir, Cirstina, Carballo, Laia, Castellvi, Josep, Temprana Salvador, Jordi, Lorente, Juan, Benavente, Sergi, García Pedrero, Juana María|||0000-0002-5891-9488, Allonca Campa, Eva|||0000-0002-2532-5421, Rodrigo Tapia, Juan Pablo|||0000-0003-3063-0890, Lleonart, Matilde E.
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad de Oviedo (UNIOVI)
Repositorio:RUO. Repositorio Institucional de la Universidad de Oviedo
Idioma:inglés
OAI Identifier:oai:digibuo.uniovi.es:10651/58154
Acceso en línea:http://hdl.handle.net/10651/58154
https://dx.doi.org/10.3390/cancers12113269
Access Level:acceso abierto
Palabra clave:Cáncer de cabeza y cuello
Descripción
Sumario:Therapy resistance in head and neck squamous cell carcinoma (HNSCC) patients is the main obstacle to achieve more e ective treatments that improve survival and quality of life of these patients. Therefore, it is of vital importance to unravel the molecular and cellular mechanisms by which tumor cells acquire resistance to chemotherapy. We conducted a comparative proteomic study involving cisplatin-resistant cells and cancer stem cells with the aim of identifying proteins potentially implicated in the acquisition of cisplatin resistance. Through this study, we identified for the first time tetraspanin-1 (TSPAN1) as an important protein involved in the development, progression and chemoresistance of HNSCC tumors.

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