The Role of Reactive Species on Innate Immunity

This review examines the role of reactive species RS (of oxygen ROS, nitrogen RNS and halogen RHS) on innate immunity. The importance of these species in innate immunity was first recognized in phagocytes that underwent a “respiratory burst” after activation. The anion superoxide O2 and hydrogen per...

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Autores: Curieses Andrés, Celia María, Pérez de la Lastra, José Manuel, Andrés Juan, Celia, Plou Gasca, Francisco José, Pérez-Lebeña, Eduardo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/283966
Acceso en línea:http://hdl.handle.net/10261/283966
Access Level:acceso abierto
Palabra clave:Reactive species
ROS
RNS and RHS
Innate immunity
Antimicrobial
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spelling The Role of Reactive Species on Innate ImmunityCurieses Andrés, Celia MaríaPérez de la Lastra, José ManuelAndrés Juan, CeliaPlou Gasca, Francisco JoséPérez-Lebeña, EduardoReactive speciesROSRNS and RHSInnate immunityAntimicrobialThis review examines the role of reactive species RS (of oxygen ROS, nitrogen RNS and halogen RHS) on innate immunity. The importance of these species in innate immunity was first recognized in phagocytes that underwent a “respiratory burst” after activation. The anion superoxide O2 and hydrogen peroxide H2O2 are detrimental to the microbial population. NADPH oxidase NOx, as an O2 producer is essential for microbial destruction, and patients lacking this functional oxidase are more susceptible to microbial infections. Reactive nitrogen species RNS (the most important are nitric oxide radical - NO, peroxynitrite ONOO— and its derivatives), are also harmful to microorganisms, including bacteria, viruses, and parasites. Hypochlorous acid HOCl and hypothiocyanous acid HOSCN synthesized through the enzyme myeloperoxidase MPO, which catalyzes the reaction between H2O2 and Cl or SCN, are important inorganic bactericidal molecules, effective against a wide range of microbes. This review also discusses the role of antimicrobial peptides AMPs and their induction of ROS. In summary, reactive species RS are the heart of the innate immune system, and they are necessary for microbial lysis in infections that can affect mammals throughout their lives.This research was funded by project APOGEO (Cooperation Program INTERREG-MAC 2014–2020, with European Funds for Regional Development-FEDER. “Agencia Canaria de Investigación, Innovación y Sociedad de la Información (ACIISI) del Gobierno de Canarias”, project ProID2020010134, Caja Canarias, Project 2019SP43 and Spanish Ministry of Economy and Competitiveness (Grant PID2019-105838RB-C31).Peer reviewedMolecular Diversity Preservation InternationalEuropean CommissionAgencia Canaria de Investigación, Innovación y Sociedad de la InformaciónGobierno de CanariasCaja CanariasMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Pérez de Lastra, José Manuel [0000-0003-4663-5565]Plou Gasca, Francisco José [0000-0003-0831-893X]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/283966reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105838RB-C31https://doi.org/10.3390/vaccines10101735Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2839662026-05-22T06:33:51Z
dc.title.none.fl_str_mv The Role of Reactive Species on Innate Immunity
title The Role of Reactive Species on Innate Immunity
spellingShingle The Role of Reactive Species on Innate Immunity
Curieses Andrés, Celia María
Reactive species
ROS
RNS and RHS
Innate immunity
Antimicrobial
title_short The Role of Reactive Species on Innate Immunity
title_full The Role of Reactive Species on Innate Immunity
title_fullStr The Role of Reactive Species on Innate Immunity
title_full_unstemmed The Role of Reactive Species on Innate Immunity
title_sort The Role of Reactive Species on Innate Immunity
dc.creator.none.fl_str_mv Curieses Andrés, Celia María
Pérez de la Lastra, José Manuel
Andrés Juan, Celia
Plou Gasca, Francisco José
Pérez-Lebeña, Eduardo
author Curieses Andrés, Celia María
author_facet Curieses Andrés, Celia María
Pérez de la Lastra, José Manuel
Andrés Juan, Celia
Plou Gasca, Francisco José
Pérez-Lebeña, Eduardo
author_role author
author2 Pérez de la Lastra, José Manuel
Andrés Juan, Celia
Plou Gasca, Francisco José
Pérez-Lebeña, Eduardo
author2_role author
author
author
author
dc.contributor.none.fl_str_mv European Commission
Agencia Canaria de Investigación, Innovación y Sociedad de la Información
Gobierno de Canarias
Caja Canarias
Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Pérez de Lastra, José Manuel [0000-0003-4663-5565]
Plou Gasca, Francisco José [0000-0003-0831-893X]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Reactive species
ROS
RNS and RHS
Innate immunity
Antimicrobial
topic Reactive species
ROS
RNS and RHS
Innate immunity
Antimicrobial
description This review examines the role of reactive species RS (of oxygen ROS, nitrogen RNS and halogen RHS) on innate immunity. The importance of these species in innate immunity was first recognized in phagocytes that underwent a “respiratory burst” after activation. The anion superoxide O2 and hydrogen peroxide H2O2 are detrimental to the microbial population. NADPH oxidase NOx, as an O2 producer is essential for microbial destruction, and patients lacking this functional oxidase are more susceptible to microbial infections. Reactive nitrogen species RNS (the most important are nitric oxide radical - NO, peroxynitrite ONOO— and its derivatives), are also harmful to microorganisms, including bacteria, viruses, and parasites. Hypochlorous acid HOCl and hypothiocyanous acid HOSCN synthesized through the enzyme myeloperoxidase MPO, which catalyzes the reaction between H2O2 and Cl or SCN, are important inorganic bactericidal molecules, effective against a wide range of microbes. This review also discusses the role of antimicrobial peptides AMPs and their induction of ROS. In summary, reactive species RS are the heart of the innate immune system, and they are necessary for microbial lysis in infections that can affect mammals throughout their lives.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/283966
url http://hdl.handle.net/10261/283966
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105838RB-C31
https://doi.org/10.3390/vaccines10101735
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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