Frequency-Dependent Intrinsic Electrophysiological Functional Architecture of the Human Verbal Language Network

Published: 26 May 2020

Detalles Bibliográficos
Autores: Coolen, Tim, Wens, Vincent, Vander Ghinst, Marc, Mary, Alison, Bourguignon, Mathieu, Naeije, Gilles, Peigneux, Philippe, Sadeghi, Niloufar, Goldman, Serge, De Tiège, Xavier
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/44103
Acceso en línea:http://hdl.handle.net/10810/44103
Access Level:acceso abierto
Palabra clave:language
magnetoencephalography
rest
brain mapping
nerve net
neuroimaging
humans
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spelling Frequency-Dependent Intrinsic Electrophysiological Functional Architecture of the Human Verbal Language NetworkCoolen, TimWens, VincentVander Ghinst, MarcMary, AlisonBourguignon, MathieuNaeije, GillesPeigneux, PhilippeSadeghi, NiloufarGoldman, SergeDe Tiège, Xavierlanguagemagnetoencephalographyrestbrain mappingnerve netneuroimaginghumansPublished: 26 May 2020Functional magnetic resonance imaging (fMRI) allowed the spatial characterization of the resting-state verbal language network (vLN). While other resting-state networks (RSNs) were matched with their electrophysiological equivalents at rest and could be spectrally defined, such correspondence is lacking for the vLN. This magnetoencephalography (MEG) study aimed at defining the spatio-spectral characteristics of the neuromagnetic intrinsic functional architecture of the vLN. Neuromagnetic activity was recorded at rest in 100 right-handed healthy adults (age range: 18–41 years). Band-limited power envelope correlations were performed within and across frequency bands (", a, b, and low g) from a seed region placed in the left Broca’s area, using static orthogonalization as leakage correction. K-means clustering was used to segregate spatio-spectral clusters of resting-state functional connectivity (rsFC). Remarkably, unlike other RSNs, withinfrequency long-range rsFC from the left Broca’s area was not driven by one main carrying frequency but was characterized by a specific spatio-spectral pattern segregated along the ventral (predominantly " and a) and dorsal (b and low-g bands) vLN streams. In contrast, spatial patterns of cross-frequency vLN functional integration were spectrally more widespread and involved multiple frequency bands. Moreover, the static intrinsic functional architecture of the neuromagnetic human vLN involved clearly left-hemispheredominant vLN interactions as well as cross-network interactions with the executive control network and postero-medial nodes of the DMN. Overall, this study highlighted the involvement of multiple modes of within and cross-frequency power envelope couplings at the basis of long-range electrophysiological vLN functional integration. As such, it lays the foundation for future works aimed at understanding the pathophysiology of languagerelated disorders.TC is Clinical Master Specialist Applicant to a PhD at the Fonds de la Recherche Scientifique (FRS-FNRS, Brussels, Belgium).MV has been supported by the Fonds Erasme (Brussels, Belgium). GN and XDT are Postdoctorate Clinical Master Specialists at the FRS-FNRS (Brussels, Belgium). This study and the MEG project at the CUB HOopital Erasme are financially supported by the Fonds Erasme (Research Convention ‘‘Les Voies du Savoir,’’ Brussels, Belgium).Frontiers in Integrative Neuroscience202020202020info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/44103reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://www.frontiersin.org/journals/integrative-neuroscience#info:eu-repo/semantics/openAccessCopyright © 2020 Coolen, Wens, Vander Ghinst, Mary, Bourguignon, Naeije, Peigneux, Sadeghi, Goldman and De Tiège. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.oai:addi.ehu.eus:10810/441032026-06-18T09:23:17Z
dc.title.none.fl_str_mv Frequency-Dependent Intrinsic Electrophysiological Functional Architecture of the Human Verbal Language Network
title Frequency-Dependent Intrinsic Electrophysiological Functional Architecture of the Human Verbal Language Network
spellingShingle Frequency-Dependent Intrinsic Electrophysiological Functional Architecture of the Human Verbal Language Network
Coolen, Tim
language
magnetoencephalography
rest
brain mapping
nerve net
neuroimaging
humans
title_short Frequency-Dependent Intrinsic Electrophysiological Functional Architecture of the Human Verbal Language Network
title_full Frequency-Dependent Intrinsic Electrophysiological Functional Architecture of the Human Verbal Language Network
title_fullStr Frequency-Dependent Intrinsic Electrophysiological Functional Architecture of the Human Verbal Language Network
title_full_unstemmed Frequency-Dependent Intrinsic Electrophysiological Functional Architecture of the Human Verbal Language Network
title_sort Frequency-Dependent Intrinsic Electrophysiological Functional Architecture of the Human Verbal Language Network
dc.creator.none.fl_str_mv Coolen, Tim
Wens, Vincent
Vander Ghinst, Marc
Mary, Alison
Bourguignon, Mathieu
Naeije, Gilles
Peigneux, Philippe
Sadeghi, Niloufar
Goldman, Serge
De Tiège, Xavier
author Coolen, Tim
author_facet Coolen, Tim
Wens, Vincent
Vander Ghinst, Marc
Mary, Alison
Bourguignon, Mathieu
Naeije, Gilles
Peigneux, Philippe
Sadeghi, Niloufar
Goldman, Serge
De Tiège, Xavier
author_role author
author2 Wens, Vincent
Vander Ghinst, Marc
Mary, Alison
Bourguignon, Mathieu
Naeije, Gilles
Peigneux, Philippe
Sadeghi, Niloufar
Goldman, Serge
De Tiège, Xavier
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv language
magnetoencephalography
rest
brain mapping
nerve net
neuroimaging
humans
topic language
magnetoencephalography
rest
brain mapping
nerve net
neuroimaging
humans
description Published: 26 May 2020
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/44103
url http://hdl.handle.net/10810/44103
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.frontiersin.org/journals/integrative-neuroscience#
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers in Integrative Neuroscience
publisher.none.fl_str_mv Frontiers in Integrative Neuroscience
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869407450134740992
score 15,300724

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