Conducting polymer nanoparticles for voltage-controlled release of pharmacological chaperones

Pharmacological chaperones (PCs) are low-molecular weight chemical molecules used in patients for the treatment of some rare diseases caused primarily by protein instability. A controlled and on-demand release of PCs via nanoparticles is an alternative for cases in which long treatments are needed a...

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Autores: Enshaei, Hamidreza, Puiggalí Jou, Anna|||0000-0002-2234-9436, Saperas Plana, Núria|||0000-0002-5419-7502, Alemán Llansó, Carlos|||0000-0003-4462-6075
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/343511
Acceso en línea:https://hdl.handle.net/2117/343511
https://dx.doi.org/10.1039/D1SM00036E
Access Level:acceso abierto
Palabra clave:Conducting polymers
Polímers conductors
Àrees temàtiques de la UPC::Enginyeria química
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repository_id_str
spelling Conducting polymer nanoparticles for voltage-controlled release of pharmacological chaperonesEnshaei, HamidrezaPuiggalí Jou, Anna|||0000-0002-2234-9436Saperas Plana, Núria|||0000-0002-5419-7502Alemán Llansó, Carlos|||0000-0003-4462-6075Conducting polymersPolímers conductorsÀrees temàtiques de la UPC::Enginyeria químicaPharmacological chaperones (PCs) are low-molecular weight chemical molecules used in patients for the treatment of some rare diseases caused primarily by protein instability. A controlled and on-demand release of PCs via nanoparticles is an alternative for cases in which long treatments are needed and prolonged oral administration could have adverse effects. In this work, pyrimethamine (PYR), which is a potent PC consisting of pyrimidine-2,4-diamine substituted at position 5 by a p-chlorophenyl group and at position 6 by an ethyl group, was successfully loaded in electroresponsive poly(3,4-ethylenedioxythiophene) nanoparticles (PEDOT NPs). The PYR-loading capacity was 11.4 ± 1.5%, with both loaded and unloaded PEDOT NPs exhibiting similar sizes (215 ± 3 and 203 ± 1 nm, respectively) and net surface charges (-26 ± 7 and -29 ± 6 mV, respectively). In the absence of electrical stimulus, the release of PC from loaded NPs is very low (1.6% in 24 h and 18% in 80 days) in aqueous environments. Instead, electrical stimuli that sustained for 30 min enhanced the release of PYR, which was ~50% when the voltage was scanned from –0.5 V to 0.5 V (cyclic voltammetry) and ~35% when a constant voltage of 1.0 V was applied (chronoamperometry).Peer ReviewedRoyal Society of Chemistry20212021-01-0120212021-04-12journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/343511https://dx.doi.org/10.1039/D1SM00036Ereponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivs 3.0 Spainhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/3435112026-05-27T15:37:01Z
dc.title.none.fl_str_mv Conducting polymer nanoparticles for voltage-controlled release of pharmacological chaperones
title Conducting polymer nanoparticles for voltage-controlled release of pharmacological chaperones
spellingShingle Conducting polymer nanoparticles for voltage-controlled release of pharmacological chaperones
Enshaei, Hamidreza
Conducting polymers
Polímers conductors
Àrees temàtiques de la UPC::Enginyeria química
title_short Conducting polymer nanoparticles for voltage-controlled release of pharmacological chaperones
title_full Conducting polymer nanoparticles for voltage-controlled release of pharmacological chaperones
title_fullStr Conducting polymer nanoparticles for voltage-controlled release of pharmacological chaperones
title_full_unstemmed Conducting polymer nanoparticles for voltage-controlled release of pharmacological chaperones
title_sort Conducting polymer nanoparticles for voltage-controlled release of pharmacological chaperones
dc.creator.none.fl_str_mv Enshaei, Hamidreza
Puiggalí Jou, Anna|||0000-0002-2234-9436
Saperas Plana, Núria|||0000-0002-5419-7502
Alemán Llansó, Carlos|||0000-0003-4462-6075
author Enshaei, Hamidreza
author_facet Enshaei, Hamidreza
Puiggalí Jou, Anna|||0000-0002-2234-9436
Saperas Plana, Núria|||0000-0002-5419-7502
Alemán Llansó, Carlos|||0000-0003-4462-6075
author_role author
author2 Puiggalí Jou, Anna|||0000-0002-2234-9436
Saperas Plana, Núria|||0000-0002-5419-7502
Alemán Llansó, Carlos|||0000-0003-4462-6075
author2_role author
author
author
dc.subject.none.fl_str_mv Conducting polymers
Polímers conductors
Àrees temàtiques de la UPC::Enginyeria química
topic Conducting polymers
Polímers conductors
Àrees temàtiques de la UPC::Enginyeria química
description Pharmacological chaperones (PCs) are low-molecular weight chemical molecules used in patients for the treatment of some rare diseases caused primarily by protein instability. A controlled and on-demand release of PCs via nanoparticles is an alternative for cases in which long treatments are needed and prolonged oral administration could have adverse effects. In this work, pyrimethamine (PYR), which is a potent PC consisting of pyrimidine-2,4-diamine substituted at position 5 by a p-chlorophenyl group and at position 6 by an ethyl group, was successfully loaded in electroresponsive poly(3,4-ethylenedioxythiophene) nanoparticles (PEDOT NPs). The PYR-loading capacity was 11.4 ± 1.5%, with both loaded and unloaded PEDOT NPs exhibiting similar sizes (215 ± 3 and 203 ± 1 nm, respectively) and net surface charges (-26 ± 7 and -29 ± 6 mV, respectively). In the absence of electrical stimulus, the release of PC from loaded NPs is very low (1.6% in 24 h and 18% in 80 days) in aqueous environments. Instead, electrical stimuli that sustained for 30 min enhanced the release of PYR, which was ~50% when the voltage was scanned from –0.5 V to 0.5 V (cyclic voltammetry) and ~35% when a constant voltage of 1.0 V was applied (chronoamperometry).
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01
2021
2021-04-12
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/343511
https://dx.doi.org/10.1039/D1SM00036E
url https://hdl.handle.net/2117/343511
https://dx.doi.org/10.1039/D1SM00036E
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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