Gαi proteins are indispensable for hearing

[Background/Aims] From invertebrates to mammals, Gαi proteins act together with their common binding partner Gpsm2 to govern cell polarization and planar organization in virtually any polarized cell. Recently, we demonstrated that Gαi3-deficiency in pre-hearing murine cochleae pointed to a role of G...

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Detalles Bibliográficos
Autores: Beer-Hammer, Sandra, Lee, Sze Chim, Mauriac, Stephanie A., Leiss, Veronika, Groh, Isabel A. M., Novakovic, Ana, Piekorz, Roland P., Bucher, Kirsten, Chen, Chengfang, Ni, Kun, Singer, Wibke, Harasztosi, Csaba, Schimmang, Thomas, Zimmermann, Ulrike, Pfeffer, Klaus, Birnbaumer, Lutz, Forge, Andrew, Montcouquiol, Mireille, Knipper, Marlies, Nürnberg, Bernd, Rüttiger, Lukas
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/196655
Acceso en línea:http://hdl.handle.net/10261/196655
Access Level:acceso abierto
Palabra clave:Heterotrimeric G-proteins
Cochlear hair cell maturation
Stereocilia bundle
Gαi3/GNAI3
Descripción
Sumario:[Background/Aims] From invertebrates to mammals, Gαi proteins act together with their common binding partner Gpsm2 to govern cell polarization and planar organization in virtually any polarized cell. Recently, we demonstrated that Gαi3-deficiency in pre-hearing murine cochleae pointed to a role of Gαi3 for asymmetric migration of the kinocilium as well as the orientation and shape of the stereociliary (“hair”) bundle, a requirement for the progression of mature hearing. We found that the lack of Gαi3 impairs stereociliary elongation and hair bundle shape in high-frequency cochlear regions, linked to elevated hearing thresholds for high-frequency sound. How these morphological defects translate into hearing phenotypes is not clear.

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