Microdosimetry and Dose-Averaged LET Calculations of Protons in Liquid Water: A Novel Geant4-DNA Application

The spatial distribution of energy deposition events is an essential aspect in the determination of the radiobiological effects of ionizing radiation at the cellular level. Microdosimetry provides a theoretical framework for the description of these events, and has been used in several studies to ad...

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Authors: Baratto Roldán, Anna, Bertolet, Alejandro, Baiocco, Giorgio, Carabe, Alejandro, Cortés Giraldo, Miguel Antonio
Format: article
Status:Published version
Publication Date:2021
Country:España
Institution:Universidad de Sevilla (US)
Repository:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/127574
Online Access:https://hdl.handle.net/11441/127574
https://doi.org/10.3389/fphy.2021.726787
Access Level:Open access
Keyword:Dose-averaged LET
Geant4-DNA
Lineal energy
Microdosimetry
Proton therapy
Site sampling method
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spelling Microdosimetry and Dose-Averaged LET Calculations of Protons in Liquid Water: A Novel Geant4-DNA ApplicationBaratto Roldán, AnnaBertolet, AlejandroBaiocco, GiorgioCarabe, AlejandroCortés Giraldo, Miguel AntonioDose-averaged LETGeant4-DNALineal energyMicrodosimetryProton therapySite sampling methodThe spatial distribution of energy deposition events is an essential aspect in the determination of the radiobiological effects of ionizing radiation at the cellular level. Microdosimetry provides a theoretical framework for the description of these events, and has been used in several studies to address problems such as the characterization of Linear Energy Transfer (LET) and Relative Biological Effectiveness (RBE) of ion beams for proton therapy applications. Microdosimetry quantities and their distributions can be obtained by means of Monte Carlo simulations. In this work, we present a track structure Monte Carlo (MC) application, based on Geant4-DNA, for the computation of microdosimetric distributions of protons in liquid water. This application provides two sampling methods uniform and weighted, for the scoring of the quantities of interest in spherical sites, with diameters ranging from 1 to 10 μm. As an element of novelty, the work shows the approach followed to calculate, without resorting to dedicated simulations, the distribution of energy imparted to the site per electronic collision of the proton, which can be used to obtain the macroscopic dose-averaged LET as proposed by Kellerer. Furthermore, in this work the concept of effective mean chord length is proposed to take into account δ-ray influx and escape in the calculation of macroscopic dose-averaged LET for proton track segments and retrieve the agreement predicted by Kellerer’s formula. Finally, the results obtained demonstrate that our MC application is reliable and computational-efficient to perform calculations of microdosimetric distributions and dose-averaged LET of proton track segments in liquid water.Ministerio de Ciencia e Innovación RTI2018-098117-B-C21, 10.13039/501100011033European Union 675265Frontiers Media S.A.Física Atómica, Molecular y Nuclear2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/127574https://doi.org/10.3389/fphy.2021.726787reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésFrontiers in Physics, 9, 726787.RTI2018-098117-B-C2110.13039/501100011033675265https://doi.org/10.3389/fphy.2021.726787info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1275742026-06-17T12:51:07Z
dc.title.none.fl_str_mv Microdosimetry and Dose-Averaged LET Calculations of Protons in Liquid Water: A Novel Geant4-DNA Application
title Microdosimetry and Dose-Averaged LET Calculations of Protons in Liquid Water: A Novel Geant4-DNA Application
spellingShingle Microdosimetry and Dose-Averaged LET Calculations of Protons in Liquid Water: A Novel Geant4-DNA Application
Baratto Roldán, Anna
Dose-averaged LET
Geant4-DNA
Lineal energy
Microdosimetry
Proton therapy
Site sampling method
title_short Microdosimetry and Dose-Averaged LET Calculations of Protons in Liquid Water: A Novel Geant4-DNA Application
title_full Microdosimetry and Dose-Averaged LET Calculations of Protons in Liquid Water: A Novel Geant4-DNA Application
title_fullStr Microdosimetry and Dose-Averaged LET Calculations of Protons in Liquid Water: A Novel Geant4-DNA Application
title_full_unstemmed Microdosimetry and Dose-Averaged LET Calculations of Protons in Liquid Water: A Novel Geant4-DNA Application
title_sort Microdosimetry and Dose-Averaged LET Calculations of Protons in Liquid Water: A Novel Geant4-DNA Application
dc.creator.none.fl_str_mv Baratto Roldán, Anna
Bertolet, Alejandro
Baiocco, Giorgio
Carabe, Alejandro
Cortés Giraldo, Miguel Antonio
author Baratto Roldán, Anna
author_facet Baratto Roldán, Anna
Bertolet, Alejandro
Baiocco, Giorgio
Carabe, Alejandro
Cortés Giraldo, Miguel Antonio
author_role author
author2 Bertolet, Alejandro
Baiocco, Giorgio
Carabe, Alejandro
Cortés Giraldo, Miguel Antonio
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Física Atómica, Molecular y Nuclear
dc.subject.none.fl_str_mv Dose-averaged LET
Geant4-DNA
Lineal energy
Microdosimetry
Proton therapy
Site sampling method
topic Dose-averaged LET
Geant4-DNA
Lineal energy
Microdosimetry
Proton therapy
Site sampling method
description The spatial distribution of energy deposition events is an essential aspect in the determination of the radiobiological effects of ionizing radiation at the cellular level. Microdosimetry provides a theoretical framework for the description of these events, and has been used in several studies to address problems such as the characterization of Linear Energy Transfer (LET) and Relative Biological Effectiveness (RBE) of ion beams for proton therapy applications. Microdosimetry quantities and their distributions can be obtained by means of Monte Carlo simulations. In this work, we present a track structure Monte Carlo (MC) application, based on Geant4-DNA, for the computation of microdosimetric distributions of protons in liquid water. This application provides two sampling methods uniform and weighted, for the scoring of the quantities of interest in spherical sites, with diameters ranging from 1 to 10 μm. As an element of novelty, the work shows the approach followed to calculate, without resorting to dedicated simulations, the distribution of energy imparted to the site per electronic collision of the proton, which can be used to obtain the macroscopic dose-averaged LET as proposed by Kellerer. Furthermore, in this work the concept of effective mean chord length is proposed to take into account δ-ray influx and escape in the calculation of macroscopic dose-averaged LET for proton track segments and retrieve the agreement predicted by Kellerer’s formula. Finally, the results obtained demonstrate that our MC application is reliable and computational-efficient to perform calculations of microdosimetric distributions and dose-averaged LET of proton track segments in liquid water.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/127574
https://doi.org/10.3389/fphy.2021.726787
url https://hdl.handle.net/11441/127574
https://doi.org/10.3389/fphy.2021.726787
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Frontiers in Physics, 9, 726787.
RTI2018-098117-B-C21
10.13039/501100011033
675265
https://doi.org/10.3389/fphy.2021.726787
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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