Cardiac-Specific Overexpression of ERRγ in Mice Induces Severe Heart Dysfunction and Early Lethality
Disfunció cardíaca; Receptors relacionats amb estrògens; Ratolins transgènics
| Autores: | , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:11351/7344 |
| Acceso en línea: | https://hdl.handle.net/11351/7344 http://hdl.handle.net/11351/7344 |
| Access Level: | acceso abierto |
| Palabra clave: | Cor - Metabolisme Miocardi - Malalties - Metabolisme ANATOMY::Cells::Muscle Cells::Myocytes, Cardiac DISEASES::Cardiovascular Diseases::Heart Diseases::Cardiomegaly::Cardiomyopathy, Dilated Other subheadings::Other subheadings::Other subheadings::/metabolism ANATOMÍA::células::células musculares::miocitos cardíacos ENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas::cardiomegalia::miocardiopatía dilatada Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo |
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Cardiac-Specific Overexpression of ERRγ in Mice Induces Severe Heart Dysfunction and Early Lethality |
| title |
Cardiac-Specific Overexpression of ERRγ in Mice Induces Severe Heart Dysfunction and Early Lethality |
| spellingShingle |
Cardiac-Specific Overexpression of ERRγ in Mice Induces Severe Heart Dysfunction and Early Lethality Lasheras Márquez, Jaime Cor - Metabolisme Miocardi - Malalties - Metabolisme ANATOMY::Cells::Muscle Cells::Myocytes, Cardiac DISEASES::Cardiovascular Diseases::Heart Diseases::Cardiomegaly::Cardiomyopathy, Dilated Other subheadings::Other subheadings::Other subheadings::/metabolism ANATOMÍA::células::células musculares::miocitos cardíacos ENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas::cardiomegalia::miocardiopatía dilatada Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo |
| title_short |
Cardiac-Specific Overexpression of ERRγ in Mice Induces Severe Heart Dysfunction and Early Lethality |
| title_full |
Cardiac-Specific Overexpression of ERRγ in Mice Induces Severe Heart Dysfunction and Early Lethality |
| title_fullStr |
Cardiac-Specific Overexpression of ERRγ in Mice Induces Severe Heart Dysfunction and Early Lethality |
| title_full_unstemmed |
Cardiac-Specific Overexpression of ERRγ in Mice Induces Severe Heart Dysfunction and Early Lethality |
| title_sort |
Cardiac-Specific Overexpression of ERRγ in Mice Induces Severe Heart Dysfunction and Early Lethality |
| dc.creator.none.fl_str_mv |
Lasheras Márquez, Jaime Pardo Diaz, Rosario Velilla Cajo, Marc Poncelas Nozal, Marcos Salvatella Serrallonga, Nuria Villena Delgado, Josep A Simó Canonge, Rafael Ruiz Meana, Marisol |
| author |
Lasheras Márquez, Jaime |
| author_facet |
Lasheras Márquez, Jaime Pardo Diaz, Rosario Velilla Cajo, Marc Poncelas Nozal, Marcos Salvatella Serrallonga, Nuria Villena Delgado, Josep A Simó Canonge, Rafael Ruiz Meana, Marisol |
| author_role |
author |
| author2 |
Pardo Diaz, Rosario Velilla Cajo, Marc Poncelas Nozal, Marcos Salvatella Serrallonga, Nuria Villena Delgado, Josep A Simó Canonge, Rafael Ruiz Meana, Marisol |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [Lasheras J, Pardo R, Velilla M, Salvatella N] Laboratori de Metabolisme i Obesitat, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Poncelas M, Ruiz-Meana M] Laboratori de Cardiologia Experimental, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Simó R] Unitat de Diabetis i Metabolisme, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBER on Diabetes and Associated Metabolic Diseases (CIBERDEM), 28029 Madrid, Spain. [Villena JA] Laboratori de Metabolisme i Obesitat, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBER on Diabetes and Associated Metabolic Diseases (CIBERDEM), 28029 Madrid, Spain Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Cor - Metabolisme Miocardi - Malalties - Metabolisme ANATOMY::Cells::Muscle Cells::Myocytes, Cardiac DISEASES::Cardiovascular Diseases::Heart Diseases::Cardiomegaly::Cardiomyopathy, Dilated Other subheadings::Other subheadings::Other subheadings::/metabolism ANATOMÍA::células::células musculares::miocitos cardíacos ENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas::cardiomegalia::miocardiopatía dilatada Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo |
| topic |
Cor - Metabolisme Miocardi - Malalties - Metabolisme ANATOMY::Cells::Muscle Cells::Myocytes, Cardiac DISEASES::Cardiovascular Diseases::Heart Diseases::Cardiomegaly::Cardiomyopathy, Dilated Other subheadings::Other subheadings::Other subheadings::/metabolism ANATOMÍA::células::células musculares::miocitos cardíacos ENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas::cardiomegalia::miocardiopatía dilatada Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo |
| description |
Disfunció cardíaca; Receptors relacionats amb estrògens; Ratolins transgènics |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2022 2022 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/11351/7344 http://hdl.handle.net/11351/7344 |
| url |
https://hdl.handle.net/11351/7344 http://hdl.handle.net/11351/7344 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
International Journal of Molecular Sciences;22(15) https://doi.org/10.3390/ijms22158047 |
| dc.rights.none.fl_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
MDPI |
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MDPI |
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Scientia reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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| _version_ |
1869407431007666176 |
| spelling |
Cardiac-Specific Overexpression of ERRγ in Mice Induces Severe Heart Dysfunction and Early LethalityLasheras Márquez, JaimePardo Diaz, RosarioVelilla Cajo, MarcPoncelas Nozal, MarcosSalvatella Serrallonga, NuriaVillena Delgado, Josep ASimó Canonge, RafaelRuiz Meana, MarisolCor - MetabolismeMiocardi - Malalties - MetabolismeANATOMY::Cells::Muscle Cells::Myocytes, CardiacDISEASES::Cardiovascular Diseases::Heart Diseases::Cardiomegaly::Cardiomyopathy, DilatedOther subheadings::Other subheadings::Other subheadings::/metabolismANATOMÍA::células::células musculares::miocitos cardíacosENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas::cardiomegalia::miocardiopatía dilatadaOtros calificadores::Otros calificadores::Otros calificadores::/metabolismoDisfunció cardíaca; Receptors relacionats amb estrògens; Ratolins transgènicsDisfunción cardíaca; Receptores relacionados con el estrógeno; Ratones transgénicosCardiac dysfunction; Estrogen-related receptors; Transgenic miceProper cardiac function depends on the coordinated expression of multiple gene networks related to fuel utilization and mitochondrial ATP production, heart contraction, and ion transport. Key transcriptional regulators that regulate these gene networks have been identified. Among them, estrogen-related receptors (ERRs) have emerged as crucial modulators of cardiac function by regulating cellular metabolism and contraction machinery. Consistent with this role, lack of ERRα or ERRγ results in cardiac derangements that lead to functional maladaptation in response to increased workload. Interestingly, metabolic inflexibility associated with diabetic cardiomyopathy has been recently associated with increased mitochondrial fatty acid oxidation and expression of ERRγ, suggesting that sustained expression of this nuclear receptor could result in a cardiac pathogenic outcome. Here, we describe the generation of mice with cardiac-specific overexpression of ERRγ, which die at young ages due to heart failure. ERRγ transgenic mice show signs of dilated cardiomyopathy associated with cardiomyocyte hypertrophy, increased cell death, and fibrosis. Our results suggest that ERRγ could play a role in mediating cardiac pathogenic responses.Research was funded by “Fundació la Marató de TV3” (# 082610 to JAV) and by Instituto de Salud Carlos III (PI19/00167 to MZ, co-funded by European Regional Development Fund -FEDER- “A way to make Europe”).MDPIInstitut Català de la Salut[Lasheras J, Pardo R, Velilla M, Salvatella N] Laboratori de Metabolisme i Obesitat, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Poncelas M, Ruiz-Meana M] Laboratori de Cardiologia Experimental, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Simó R] Unitat de Diabetis i Metabolisme, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBER on Diabetes and Associated Metabolic Diseases (CIBERDEM), 28029 Madrid, Spain. [Villena JA] Laboratori de Metabolisme i Obesitat, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBER on Diabetes and Associated Metabolic Diseases (CIBERDEM), 28029 Madrid, SpainVall d'Hebron Barcelona Hospital Campus202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/7344http://hdl.handle.net/11351/7344Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésInternational Journal of Molecular Sciences;22(15)https://doi.org/10.3390/ijms22158047Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/73442026-05-29T05:05:01Z |
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15,811543 |