Importance of iron deficiency in patients with chronic heart failure as a predictor of mortality and hospitalizations: insights from an observational cohort study

BACKGROUND: Iron deficiency (ID) in patients with chronic heart failure (CHF) is considered an adverse prognostic factor. We aimed to evaluate if ID in patients with CHF is associated with increased mortality and hospitalizations. METHODS: We evaluated ID in patients with CHF at 3 university hospita...

Descripción completa

Detalles Bibliográficos
Autores: González-Costello, José, Comín Colet, Josep, Lupón, Josep, Enjuanes Grau, Cristina, Antonio, Marta de, Fuentes, Lara, Moliner Borja, Pedro, Farré López, Núria, Zamora, Elisabet, Manito Lorite, Nicolás, Pujol Vallverdú, Ramon Maria, Bayes-Genis, Antoni
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/36796
Acceso en línea:http://hdl.handle.net/10230/36796
http://dx.doi.org/10.1186/s12872-018-0942-x
Access Level:acceso abierto
Palabra clave:Malalts hospitalitzats
Aliments--Contingut en ferro
Infart
Mortalitat
Chronic heart failure
Hospitalization
Iron deficiency
Mortality
id ES_498b9cd4d4a8597a2e4fed853b2a1f2a
oai_identifier_str oai:repositori.upf.edu:10230/36796
network_acronym_str ES
network_name_str España
repository_id_str
spelling Importance of iron deficiency in patients with chronic heart failure as a predictor of mortality and hospitalizations: insights from an observational cohort studyGonzález-Costello, JoséComín Colet, JosepLupón, JosepEnjuanes Grau, CristinaAntonio, Marta deFuentes, LaraMoliner Borja, PedroFarré López, NúriaZamora, ElisabetManito Lorite, NicolásPujol Vallverdú, Ramon MariaBayes-Genis, AntoniMalalts hospitalitzatsAliments--Contingut en ferroInfartMortalitatChronic heart failureHospitalizationIron deficiencyMortalityBACKGROUND: Iron deficiency (ID) in patients with chronic heart failure (CHF) is considered an adverse prognostic factor. We aimed to evaluate if ID in patients with CHF is associated with increased mortality and hospitalizations. METHODS: We evaluated ID in patients with CHF at 3 university hospitals. ID was defined as absolute (ferritin < 100 μg/L) or functional (transferrin Saturation index < 20% and ferritin between 100 and 299 μg/L). We excluded patients who received treatment with intravenous Iron or Erythropoietin during follow-up. We evaluated if ID was a predictor of death or hospitalization due to heart failure or any cause using univariate and multivariate cox regression analysis. RESULTS: We included 1684 patients, 65% males, 38% diabetics, median age of 72 years, 37% in functional class III-IV and 30% of patients with a left ventricular ejection fraction > 45%. Patients were well treated, with 87% and 88% of patients receiving renin-angiotensin inhibitors and beta-blockers, respectively. Median transferrin saturation index was 20%, median ferritin 155 ng/mL and median haemoglobin 13 g/dL. ID was present in 53% of patients; in 35% it was absolute and in 18% functional. Median follow-up was 20 months. ID was a predictor of death, hospitalization due to heart failure or to any cause in univariate analysis but not after multivariate analysis. No differences were found between absolute or functional ID regarding prognosis. CONCLUSION: In a real life population of patients with CHF and a high prevalence of heart failure with preserved ejection fraction, ID did not predict mortality or hospitalizations after adjustment for comorbidities, functional class and neurohormonal treatment.BioMed Central201920192018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/36796http://dx.doi.org/10.1186/s12872-018-0942-xreponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésBMC Cardiovascular Disorders. 2018 Nov 1;18(1):206© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/367962026-06-12T07:21:37Z
dc.title.none.fl_str_mv Importance of iron deficiency in patients with chronic heart failure as a predictor of mortality and hospitalizations: insights from an observational cohort study
title Importance of iron deficiency in patients with chronic heart failure as a predictor of mortality and hospitalizations: insights from an observational cohort study
spellingShingle Importance of iron deficiency in patients with chronic heart failure as a predictor of mortality and hospitalizations: insights from an observational cohort study
González-Costello, José
Malalts hospitalitzats
Aliments--Contingut en ferro
Infart
Mortalitat
Chronic heart failure
Hospitalization
Iron deficiency
Mortality
title_short Importance of iron deficiency in patients with chronic heart failure as a predictor of mortality and hospitalizations: insights from an observational cohort study
title_full Importance of iron deficiency in patients with chronic heart failure as a predictor of mortality and hospitalizations: insights from an observational cohort study
title_fullStr Importance of iron deficiency in patients with chronic heart failure as a predictor of mortality and hospitalizations: insights from an observational cohort study
title_full_unstemmed Importance of iron deficiency in patients with chronic heart failure as a predictor of mortality and hospitalizations: insights from an observational cohort study
title_sort Importance of iron deficiency in patients with chronic heart failure as a predictor of mortality and hospitalizations: insights from an observational cohort study
dc.creator.none.fl_str_mv González-Costello, José
Comín Colet, Josep
Lupón, Josep
Enjuanes Grau, Cristina
Antonio, Marta de
Fuentes, Lara
Moliner Borja, Pedro
Farré López, Núria
Zamora, Elisabet
Manito Lorite, Nicolás
Pujol Vallverdú, Ramon Maria
Bayes-Genis, Antoni
author González-Costello, José
author_facet González-Costello, José
Comín Colet, Josep
Lupón, Josep
Enjuanes Grau, Cristina
Antonio, Marta de
Fuentes, Lara
Moliner Borja, Pedro
Farré López, Núria
Zamora, Elisabet
Manito Lorite, Nicolás
Pujol Vallverdú, Ramon Maria
Bayes-Genis, Antoni
author_role author
author2 Comín Colet, Josep
Lupón, Josep
Enjuanes Grau, Cristina
Antonio, Marta de
Fuentes, Lara
Moliner Borja, Pedro
Farré López, Núria
Zamora, Elisabet
Manito Lorite, Nicolás
Pujol Vallverdú, Ramon Maria
Bayes-Genis, Antoni
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malalts hospitalitzats
Aliments--Contingut en ferro
Infart
Mortalitat
Chronic heart failure
Hospitalization
Iron deficiency
Mortality
topic Malalts hospitalitzats
Aliments--Contingut en ferro
Infart
Mortalitat
Chronic heart failure
Hospitalization
Iron deficiency
Mortality
description BACKGROUND: Iron deficiency (ID) in patients with chronic heart failure (CHF) is considered an adverse prognostic factor. We aimed to evaluate if ID in patients with CHF is associated with increased mortality and hospitalizations. METHODS: We evaluated ID in patients with CHF at 3 university hospitals. ID was defined as absolute (ferritin < 100 μg/L) or functional (transferrin Saturation index < 20% and ferritin between 100 and 299 μg/L). We excluded patients who received treatment with intravenous Iron or Erythropoietin during follow-up. We evaluated if ID was a predictor of death or hospitalization due to heart failure or any cause using univariate and multivariate cox regression analysis. RESULTS: We included 1684 patients, 65% males, 38% diabetics, median age of 72 years, 37% in functional class III-IV and 30% of patients with a left ventricular ejection fraction > 45%. Patients were well treated, with 87% and 88% of patients receiving renin-angiotensin inhibitors and beta-blockers, respectively. Median transferrin saturation index was 20%, median ferritin 155 ng/mL and median haemoglobin 13 g/dL. ID was present in 53% of patients; in 35% it was absolute and in 18% functional. Median follow-up was 20 months. ID was a predictor of death, hospitalization due to heart failure or to any cause in univariate analysis but not after multivariate analysis. No differences were found between absolute or functional ID regarding prognosis. CONCLUSION: In a real life population of patients with CHF and a high prevalence of heart failure with preserved ejection fraction, ID did not predict mortality or hospitalizations after adjustment for comorbidities, functional class and neurohormonal treatment.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/36796
http://dx.doi.org/10.1186/s12872-018-0942-x
url http://hdl.handle.net/10230/36796
http://dx.doi.org/10.1186/s12872-018-0942-x
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv BMC Cardiovascular Disorders. 2018 Nov 1;18(1):206
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869407431000326144
score 15,811543

Similares en LA Referencia