Bisphosphonate-related osteonecrosis. Application of adipose-derived stem cells in an experimental murine model

Background: Bisphosphonate-related osteonecrosis of the jaw is a pathological condition without effective established treatment and preventive strategies. The aim of this study was to analyse the effect of adipose-derived stem cells (ASC) in an experimental murine model of osteonecrosis. Material an...

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Detalles Bibliográficos
Autores: Alonso Rodríguez, Estefanía, González Martín-Moro, Javier, Cebrián Carretero, José Luis, Castillo, José Luis del, Pozo Kreilinger, José Juan, Ruiz Bravo, Elena, García Arranz, Mariano Andrés, Hernández Godoy, Juan, Burgueño, Miguel
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/747920
Acceso en línea:https://hdl.handle.net/10486/747920
https://dx.doi.org/10.4317/medoral.22959
Access Level:acceso abierto
Palabra clave:Osteonecrosis
bisphosphonates
mesenchymal stem cells (MSC)
adipose-derived stem cells (ASCs)
zoledronic acid
Medicina
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spelling Bisphosphonate-related osteonecrosis. Application of adipose-derived stem cells in an experimental murine modelAlonso Rodríguez, EstefaníaGonzález Martín-Moro, JavierCebrián Carretero, José LuisCastillo, José Luis delPozo Kreilinger, José JuanRuiz Bravo, ElenaGarcía Arranz, Mariano AndrésHernández Godoy, JuanBurgueño, MiguelOsteonecrosisbisphosphonatesmesenchymal stem cells (MSC)adipose-derived stem cells (ASCs)zoledronic acidMedicinaBackground: Bisphosphonate-related osteonecrosis of the jaw is a pathological condition without effective established treatment and preventive strategies. The aim of this study was to analyse the effect of adipose-derived stem cells (ASC) in an experimental murine model of osteonecrosis. Material and Methods: 38 Wistar rats were injected intraperitoneally with zoledronic acid. After treatment, upper jaw molars were extracted. The animals were randomly assigned to one of two groups. In the control group, saline solution was applied over the alveolar sockets after the tooth extractions. In the treatment group, ASCs were applied instead of saline solution. The control and treatment groups were subdivided based on the time of euthanasia. A clinical and histological analysis was performed. Results: The presence of osteonecrosis in alveolar bone was observed in a similar distribution in both groups. In the ASC-treated group, new bone formation was greater than in controls. Conclusions: In this study, application of ASCs showed greater new bone formation in an osteonecrosis-like murine model. Previous inhibited post-extraction bone remodelling could be reactivated, and these findings appeared to be secondary to implantation of ASCsThis study was supported by a grant from the Fondo de Investigación Sanitaria (FIS), SpainMedicina OralDepartamento de Anatomía PatológicaDepartamento de CirugíaFacultad de MedicinaGobierno de EspañaInstituto de Salud Carlos III20192019-07-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10486/747920https://dx.doi.org/10.4317/medoral.2295931232388reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7479202026-06-23T12:46:27Z
dc.title.none.fl_str_mv Bisphosphonate-related osteonecrosis. Application of adipose-derived stem cells in an experimental murine model
title Bisphosphonate-related osteonecrosis. Application of adipose-derived stem cells in an experimental murine model
spellingShingle Bisphosphonate-related osteonecrosis. Application of adipose-derived stem cells in an experimental murine model
Alonso Rodríguez, Estefanía
Osteonecrosis
bisphosphonates
mesenchymal stem cells (MSC)
adipose-derived stem cells (ASCs)
zoledronic acid
Medicina
title_short Bisphosphonate-related osteonecrosis. Application of adipose-derived stem cells in an experimental murine model
title_full Bisphosphonate-related osteonecrosis. Application of adipose-derived stem cells in an experimental murine model
title_fullStr Bisphosphonate-related osteonecrosis. Application of adipose-derived stem cells in an experimental murine model
title_full_unstemmed Bisphosphonate-related osteonecrosis. Application of adipose-derived stem cells in an experimental murine model
title_sort Bisphosphonate-related osteonecrosis. Application of adipose-derived stem cells in an experimental murine model
dc.creator.none.fl_str_mv Alonso Rodríguez, Estefanía
González Martín-Moro, Javier
Cebrián Carretero, José Luis
Castillo, José Luis del
Pozo Kreilinger, José Juan
Ruiz Bravo, Elena
García Arranz, Mariano Andrés
Hernández Godoy, Juan
Burgueño, Miguel
author Alonso Rodríguez, Estefanía
author_facet Alonso Rodríguez, Estefanía
González Martín-Moro, Javier
Cebrián Carretero, José Luis
Castillo, José Luis del
Pozo Kreilinger, José Juan
Ruiz Bravo, Elena
García Arranz, Mariano Andrés
Hernández Godoy, Juan
Burgueño, Miguel
author_role author
author2 González Martín-Moro, Javier
Cebrián Carretero, José Luis
Castillo, José Luis del
Pozo Kreilinger, José Juan
Ruiz Bravo, Elena
García Arranz, Mariano Andrés
Hernández Godoy, Juan
Burgueño, Miguel
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Anatomía Patológica
Departamento de Cirugía
Facultad de Medicina
Gobierno de España
Instituto de Salud Carlos III
dc.subject.none.fl_str_mv Osteonecrosis
bisphosphonates
mesenchymal stem cells (MSC)
adipose-derived stem cells (ASCs)
zoledronic acid
Medicina
topic Osteonecrosis
bisphosphonates
mesenchymal stem cells (MSC)
adipose-derived stem cells (ASCs)
zoledronic acid
Medicina
description Background: Bisphosphonate-related osteonecrosis of the jaw is a pathological condition without effective established treatment and preventive strategies. The aim of this study was to analyse the effect of adipose-derived stem cells (ASC) in an experimental murine model of osteonecrosis. Material and Methods: 38 Wistar rats were injected intraperitoneally with zoledronic acid. After treatment, upper jaw molars were extracted. The animals were randomly assigned to one of two groups. In the control group, saline solution was applied over the alveolar sockets after the tooth extractions. In the treatment group, ASCs were applied instead of saline solution. The control and treatment groups were subdivided based on the time of euthanasia. A clinical and histological analysis was performed. Results: The presence of osteonecrosis in alveolar bone was observed in a similar distribution in both groups. In the ASC-treated group, new bone formation was greater than in controls. Conclusions: In this study, application of ASCs showed greater new bone formation in an osteonecrosis-like murine model. Previous inhibited post-extraction bone remodelling could be reactivated, and these findings appeared to be secondary to implantation of ASCs
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-07-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10486/747920
https://dx.doi.org/10.4317/medoral.22959
31232388
url https://hdl.handle.net/10486/747920
https://dx.doi.org/10.4317/medoral.22959
identifier_str_mv 31232388
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Medicina Oral
publisher.none.fl_str_mv Medicina Oral
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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