Vascular reactivity and biomarkers of endothelial function in healthy subjects exposed to acute hypobaric hypoxia

Aims: The aim of this study was to evaluate the effects of acute hypobaric hypoxia (HH) on vascular reactivity and biochemical markers associated with endothelial function (EF). Main methods: Ten healthy subjects were exposed to a simulated altitude of 4,000 meters above sea level for 4 hours in a h...

Descripción completa

Detalles Bibliográficos
Autores: Iglesias, Diego, Gómez Rosso, Leonardo, Vainstein, Nora, Meroño, Tomás, Lezón, Christian, Brites, Fernando
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2015
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/193923
Acceso en línea:https://hdl.handle.net/2445/193923
Access Level:acceso abierto
Palabra clave:Malalties cardiovasculars
Marcadors bioquímics
Cardiovascular diseases
Biochemical markers
id ES_49654bdf27d13e6c19351ae2a826050c
oai_identifier_str oai:diposit.ub.edu:2445/193923
network_acronym_str ES
network_name_str España
repository_id_str
spelling Vascular reactivity and biomarkers of endothelial function in healthy subjects exposed to acute hypobaric hypoxiaIglesias, DiegoGómez Rosso, LeonardoVainstein, NoraMeroño, TomásLezón, ChristianBrites, FernandoMalalties cardiovascularsMarcadors bioquímicsCardiovascular diseasesBiochemical markersAims: The aim of this study was to evaluate the effects of acute hypobaric hypoxia (HH) on vascular reactivity and biochemical markers associated with endothelial function (EF). Main methods: Ten healthy subjects were exposed to a simulated altitude of 4,000 meters above sea level for 4 hours in a hypobaric chamber. Vascular reactivity was measured by the flow-mediated vasodilatation (FMVD) test. Endothelin-1, high sensitive-C reactive protein (hsCRP), vascular cell adhesion molecule 1, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), paraoxonase and adiponectin levels, and FMVD were evaluated before and after the exposure. Key findings: Subjects were young (age: 32±6 years), lean [body mass index: 23.9±2.0kg/m(2), waist circumference: 77(IQR: 72-80) cm], and presented normal clinical and biochemical parameters. No significant changes were evidenced in FMVD in response to HH (pre: 0.45 (0.20-0.70) vs. during: 0.50 (0.20-1.22) mm; p=0.594). On the other hand, endothelin-1 (+54%, p<0.05), hsCRP (+37%, p<0.001), IL-6 (+75%, p<0.05), TNF-α (+75%, p<0.05), and adiponectin (-39%, p<0.01) levels were significantly altered post-HH. FMVD was increased in 7 subjects, and it was decreased in 3 individuals during HH exposure. Interestingly, when EF biomarkers were compared between these two subgroups of subjects, only post exposure-adiponectin levels were significantly different (49±5 vs. 38±6μg/ml, respectively, p<0.05). Significance: HH exposure had an effect on endothelin-1, adiponectin, hsCRP, IL-6, and TNF-α concentration. However, adiponectin was the only biomarker associated with an altered vascular reactivity.Elsevier B.V.2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/193923Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1016/j.clinbiochem.2015.06.007Clinical Biochemistry, 2015, num. 48, p. 1059-1063https://doi.org/10.1016/j.clinbiochem.2015.06.007cc-by-nc-nd (c) Elsevier B.V., 2015https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1939232026-05-27T06:46:51Z
dc.title.none.fl_str_mv Vascular reactivity and biomarkers of endothelial function in healthy subjects exposed to acute hypobaric hypoxia
title Vascular reactivity and biomarkers of endothelial function in healthy subjects exposed to acute hypobaric hypoxia
spellingShingle Vascular reactivity and biomarkers of endothelial function in healthy subjects exposed to acute hypobaric hypoxia
Iglesias, Diego
Malalties cardiovasculars
Marcadors bioquímics
Cardiovascular diseases
Biochemical markers
title_short Vascular reactivity and biomarkers of endothelial function in healthy subjects exposed to acute hypobaric hypoxia
title_full Vascular reactivity and biomarkers of endothelial function in healthy subjects exposed to acute hypobaric hypoxia
title_fullStr Vascular reactivity and biomarkers of endothelial function in healthy subjects exposed to acute hypobaric hypoxia
title_full_unstemmed Vascular reactivity and biomarkers of endothelial function in healthy subjects exposed to acute hypobaric hypoxia
title_sort Vascular reactivity and biomarkers of endothelial function in healthy subjects exposed to acute hypobaric hypoxia
dc.creator.none.fl_str_mv Iglesias, Diego
Gómez Rosso, Leonardo
Vainstein, Nora
Meroño, Tomás
Lezón, Christian
Brites, Fernando
author Iglesias, Diego
author_facet Iglesias, Diego
Gómez Rosso, Leonardo
Vainstein, Nora
Meroño, Tomás
Lezón, Christian
Brites, Fernando
author_role author
author2 Gómez Rosso, Leonardo
Vainstein, Nora
Meroño, Tomás
Lezón, Christian
Brites, Fernando
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Malalties cardiovasculars
Marcadors bioquímics
Cardiovascular diseases
Biochemical markers
topic Malalties cardiovasculars
Marcadors bioquímics
Cardiovascular diseases
Biochemical markers
description Aims: The aim of this study was to evaluate the effects of acute hypobaric hypoxia (HH) on vascular reactivity and biochemical markers associated with endothelial function (EF). Main methods: Ten healthy subjects were exposed to a simulated altitude of 4,000 meters above sea level for 4 hours in a hypobaric chamber. Vascular reactivity was measured by the flow-mediated vasodilatation (FMVD) test. Endothelin-1, high sensitive-C reactive protein (hsCRP), vascular cell adhesion molecule 1, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), paraoxonase and adiponectin levels, and FMVD were evaluated before and after the exposure. Key findings: Subjects were young (age: 32±6 years), lean [body mass index: 23.9±2.0kg/m(2), waist circumference: 77(IQR: 72-80) cm], and presented normal clinical and biochemical parameters. No significant changes were evidenced in FMVD in response to HH (pre: 0.45 (0.20-0.70) vs. during: 0.50 (0.20-1.22) mm; p=0.594). On the other hand, endothelin-1 (+54%, p<0.05), hsCRP (+37%, p<0.001), IL-6 (+75%, p<0.05), TNF-α (+75%, p<0.05), and adiponectin (-39%, p<0.01) levels were significantly altered post-HH. FMVD was increased in 7 subjects, and it was decreased in 3 individuals during HH exposure. Interestingly, when EF biomarkers were compared between these two subgroups of subjects, only post exposure-adiponectin levels were significantly different (49±5 vs. 38±6μg/ml, respectively, p<0.05). Significance: HH exposure had an effect on endothelin-1, adiponectin, hsCRP, IL-6, and TNF-α concentration. However, adiponectin was the only biomarker associated with an altered vascular reactivity.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/193923
url https://hdl.handle.net/2445/193923
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.clinbiochem.2015.06.007
Clinical Biochemistry, 2015, num. 48, p. 1059-1063
https://doi.org/10.1016/j.clinbiochem.2015.06.007
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Elsevier B.V., 2015
https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Elsevier B.V., 2015
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869407421512810496
score 15,301629

Similares en LA Referencia