Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with <i>TP53</i> aberrations

Blanco, Gonzalo; Puiggros, Anna; Baliakas, Panagiotis; Athanasiadou, Anastasia; García-Malo, MªDolores; Collado, Rosa; Xochelli, Aliki; Rodríguez-Rivera, María; Ortega, Margarita; Calasanz, Mª José; Luño, Elisa; Vargas, MªTeresa; Grau, Javier; Martínez-Laperche, Carolina; Valiente, Alberto; Cervera, José; Anagnostopoulos, Achilles; Gimeno, Eva; Abella, Eugènia; Stalika, Evangelia; Hernández Rivas, Jesús María; Ortuño, Francisco José; Robles, Diego; Ferrer, Ana; Ivars, David; González, Marcos; Bosch, Francesc; Abrisqueta, Pau; Stamatopoulos, Kostas; Espinet, Blanca

Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with <i>TP53</i> aberrations

[EN] Patients with chronic lymphocytic leukemia (CLL) harboring TP53 aberrations (TP53abs; chromosome 17p deletion and/or TP53 mutation) exhibit an unfavorable clinical outcome. Chromosome 8 abnormalities, namely losses of 8p (8p−) and gains of 8q (8q+) have been suggested to aggravate the outcome o...

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Autores:	Blanco, Gonzalo, Puiggros, Anna, Baliakas, Panagiotis, Athanasiadou, Anastasia, García-Malo, MªDolores, Collado, Rosa, Xochelli, Aliki, Rodríguez-Rivera, María, Ortega, Margarita, Calasanz, Mª José, Luño, Elisa, Vargas, MªTeresa, Grau, Javier, Martínez-Laperche, Carolina, Valiente, Alberto, Cervera, José, Anagnostopoulos, Achilles, Gimeno, Eva, Abella, Eugènia, Stalika, Evangelia, Hernández Rivas, Jesús María, Ortuño, Francisco José, Robles, Diego, Ferrer, Ana, Ivars, David, González, Marcos, Bosch, Francesc, Abrisqueta, Pau, Stamatopoulos, Kostas, Espinet, Blanca
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2016
País:	España
Institución:	Universidad de Salamanca (USAL)
Repositorio:	GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:	oai:gredos.usal.es:10366/140736
Acceso en línea:	http://hdl.handle.net/10366/140736
Access Level:	acceso abierto
Palabra clave:	CLL TP53 aberrations Chromosome 8 abnormalities Complex karyotype Prognosis Leukemia leucemia

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spelling	Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with <i>TP53</i> aberrationsBlanco, GonzaloPuiggros, AnnaBaliakas, PanagiotisAthanasiadou, AnastasiaGarcía-Malo, MªDoloresCollado, RosaXochelli, AlikiRodríguez-Rivera, MaríaOrtega, MargaritaCalasanz, Mª JoséLuño, ElisaVargas, MªTeresaGrau, JavierMartínez-Laperche, CarolinaValiente, AlbertoCervera, JoséAnagnostopoulos, AchillesGimeno, EvaAbella, EugèniaStalika, EvangeliaHernández Rivas, Jesús MaríaOrtuño, Francisco JoséRobles, DiegoFerrer, AnaIvars, DavidGonzález, MarcosBosch, FrancescAbrisqueta, PauStamatopoulos, KostasEspinet, BlancaCLLTP53 aberrationsChromosome 8 abnormalitiesComplex karyotypePrognosisLeukemialeucemia[EN] Patients with chronic lymphocytic leukemia (CLL) harboring TP53 aberrations (TP53abs; chromosome 17p deletion and/or TP53 mutation) exhibit an unfavorable clinical outcome. Chromosome 8 abnormalities, namely losses of 8p (8p−) and gains of 8q (8q+) have been suggested to aggravate the outcome of patients with TP53abs. However, the reported series were small, thus hindering definitive conclusions. To gain insight into this issue, we assessed a series of 101 CLL patients harboring TP53 disruption. The frequency of 8p− and 8q+ was 14.7% and 17.8% respectively. Both were associated with a significantly (P < 0.05) higher incidence of a complex karyotype (CK, ≥3 abnormalities) detected by chromosome banding analysis (CBA) compared to cases with normal 8p (N-8p) and 8q (N-8q), respectively. In univariate analysis for 10-year overall survival (OS), 8p− (P = 0.002), 8q+ (P = 0.012) and CK (P = 0.009) were associated with shorter OS. However, in multivariate analysis only CK (HR = 2.47, P = 0.027) maintained independent significance, being associated with a dismal outcome regardless of chromosome 8 abnormalities. In conclusion, our results highlight the association of chromosome 8 abnormalities with CK amongst CLL patients with TP53abs, while also revealing that CK can further aggravate the prognosis of this aggressive subgroup.202020202016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/140736reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1407362026-06-07T06:28:51Z
dc.title.none.fl_str_mv	Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with <i>TP53</i> aberrations
title	Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with <i>TP53</i> aberrations
spellingShingle	Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with <i>TP53</i> aberrations Blanco, Gonzalo CLL TP53 aberrations Chromosome 8 abnormalities Complex karyotype Prognosis Leukemia leucemia
title_short	Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with <i>TP53</i> aberrations
title_full	Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with <i>TP53</i> aberrations
title_fullStr	Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with <i>TP53</i> aberrations
title_full_unstemmed	Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with <i>TP53</i> aberrations
title_sort	Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with <i>TP53</i> aberrations
dc.creator.none.fl_str_mv	Blanco, Gonzalo Puiggros, Anna Baliakas, Panagiotis Athanasiadou, Anastasia García-Malo, MªDolores Collado, Rosa Xochelli, Aliki Rodríguez-Rivera, María Ortega, Margarita Calasanz, Mª José Luño, Elisa Vargas, MªTeresa Grau, Javier Martínez-Laperche, Carolina Valiente, Alberto Cervera, José Anagnostopoulos, Achilles Gimeno, Eva Abella, Eugènia Stalika, Evangelia Hernández Rivas, Jesús María Ortuño, Francisco José Robles, Diego Ferrer, Ana Ivars, David González, Marcos Bosch, Francesc Abrisqueta, Pau Stamatopoulos, Kostas Espinet, Blanca
author	Blanco, Gonzalo
author_facet	Blanco, Gonzalo Puiggros, Anna Baliakas, Panagiotis Athanasiadou, Anastasia García-Malo, MªDolores Collado, Rosa Xochelli, Aliki Rodríguez-Rivera, María Ortega, Margarita Calasanz, Mª José Luño, Elisa Vargas, MªTeresa Grau, Javier Martínez-Laperche, Carolina Valiente, Alberto Cervera, José Anagnostopoulos, Achilles Gimeno, Eva Abella, Eugènia Stalika, Evangelia Hernández Rivas, Jesús María Ortuño, Francisco José Robles, Diego Ferrer, Ana Ivars, David González, Marcos Bosch, Francesc Abrisqueta, Pau Stamatopoulos, Kostas Espinet, Blanca
author_role	author
author2	Puiggros, Anna Baliakas, Panagiotis Athanasiadou, Anastasia García-Malo, MªDolores Collado, Rosa Xochelli, Aliki Rodríguez-Rivera, María Ortega, Margarita Calasanz, Mª José Luño, Elisa Vargas, MªTeresa Grau, Javier Martínez-Laperche, Carolina Valiente, Alberto Cervera, José Anagnostopoulos, Achilles Gimeno, Eva Abella, Eugènia Stalika, Evangelia Hernández Rivas, Jesús María Ortuño, Francisco José Robles, Diego Ferrer, Ana Ivars, David González, Marcos Bosch, Francesc Abrisqueta, Pau Stamatopoulos, Kostas Espinet, Blanca
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	CLL TP53 aberrations Chromosome 8 abnormalities Complex karyotype Prognosis Leukemia leucemia
topic	CLL TP53 aberrations Chromosome 8 abnormalities Complex karyotype Prognosis Leukemia leucemia
description	[EN] Patients with chronic lymphocytic leukemia (CLL) harboring TP53 aberrations (TP53abs; chromosome 17p deletion and/or TP53 mutation) exhibit an unfavorable clinical outcome. Chromosome 8 abnormalities, namely losses of 8p (8p−) and gains of 8q (8q+) have been suggested to aggravate the outcome of patients with TP53abs. However, the reported series were small, thus hindering definitive conclusions. To gain insight into this issue, we assessed a series of 101 CLL patients harboring TP53 disruption. The frequency of 8p− and 8q+ was 14.7% and 17.8% respectively. Both were associated with a significantly (P < 0.05) higher incidence of a complex karyotype (CK, ≥3 abnormalities) detected by chromosome banding analysis (CBA) compared to cases with normal 8p (N-8p) and 8q (N-8q), respectively. In univariate analysis for 10-year overall survival (OS), 8p− (P = 0.002), 8q+ (P = 0.012) and CK (P = 0.009) were associated with shorter OS. However, in multivariate analysis only CK (HR = 2.47, P = 0.027) maintained independent significance, being associated with a dismal outcome regardless of chromosome 8 abnormalities. In conclusion, our results highlight the association of chromosome 8 abnormalities with CK amongst CLL patients with TP53abs, while also revealing that CK can further aggravate the prognosis of this aggressive subgroup.
publishDate	2016
dc.date.none.fl_str_mv	2016 2020 2020
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/10366/140736
url	http://hdl.handle.net/10366/140736
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv	openAccess
dc.source.none.fl_str_mv	reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca instname:Universidad de Salamanca (USAL)
instname_str	Universidad de Salamanca (USAL)
reponame_str	GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection	GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15.301603

Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with <i>TP53</i> aberrations

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