Modeling Functional Limitations, Gait Impairments, and Muscle Pathology in Alzheimer’s Disease: Studies in the 3xTg-AD Mice

Frailty; Muscular strength; Translational neuroscience

Bibliographic Details
Authors: Castillo-Mariqueo, Lidia, Pérez García, Maria Jose, Giménez-Llort, Lydia
Format: article
Status:Published version
Publication Date:2021
Country:España
Institution:Departament de Salut de la Generalitat de Catalunya (DS)
Repository:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/7545
Online Access:https://hdl.handle.net/11351/7545
Access Level:Open access
Keyword:Alzheimer, Malaltia d' - Complicacions
Rates (Animals de laboratori)
Trastorns de la marxa
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Dementia::Alzheimer Disease
Other subheadings::Other subheadings::Other subheadings::/complications
ORGANISMS::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Eutheria::Rodentia::Muridae::Murinae::Mice
DISEASES::Nervous System Diseases::Neurologic Manifestations::Gait Disorders, Neurologic
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::demencia::enfermedad de Alzheimer
Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones
ORGANISMOS::Eukaryota::animales::Chordata::vertebrados::mamíferos::Eutheria::Rodentia::Muridae::Murinae::ratones
ENFERMEDADES::enfermedades del sistema nervioso::manifestaciones neurológicas::trastornos neurológicos de la marcha
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network_name_str España
repository_id_str
dc.title.none.fl_str_mv Modeling Functional Limitations, Gait Impairments, and Muscle Pathology in Alzheimer’s Disease: Studies in the 3xTg-AD Mice
title Modeling Functional Limitations, Gait Impairments, and Muscle Pathology in Alzheimer’s Disease: Studies in the 3xTg-AD Mice
spellingShingle Modeling Functional Limitations, Gait Impairments, and Muscle Pathology in Alzheimer’s Disease: Studies in the 3xTg-AD Mice
Castillo-Mariqueo, Lidia
Alzheimer, Malaltia d' - Complicacions
Rates (Animals de laboratori)
Trastorns de la marxa
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Dementia::Alzheimer Disease
Other subheadings::Other subheadings::Other subheadings::/complications
ORGANISMS::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Eutheria::Rodentia::Muridae::Murinae::Mice
DISEASES::Nervous System Diseases::Neurologic Manifestations::Gait Disorders, Neurologic
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::demencia::enfermedad de Alzheimer
Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones
ORGANISMOS::Eukaryota::animales::Chordata::vertebrados::mamíferos::Eutheria::Rodentia::Muridae::Murinae::ratones
ENFERMEDADES::enfermedades del sistema nervioso::manifestaciones neurológicas::trastornos neurológicos de la marcha
title_short Modeling Functional Limitations, Gait Impairments, and Muscle Pathology in Alzheimer’s Disease: Studies in the 3xTg-AD Mice
title_full Modeling Functional Limitations, Gait Impairments, and Muscle Pathology in Alzheimer’s Disease: Studies in the 3xTg-AD Mice
title_fullStr Modeling Functional Limitations, Gait Impairments, and Muscle Pathology in Alzheimer’s Disease: Studies in the 3xTg-AD Mice
title_full_unstemmed Modeling Functional Limitations, Gait Impairments, and Muscle Pathology in Alzheimer’s Disease: Studies in the 3xTg-AD Mice
title_sort Modeling Functional Limitations, Gait Impairments, and Muscle Pathology in Alzheimer’s Disease: Studies in the 3xTg-AD Mice
dc.creator.none.fl_str_mv Castillo-Mariqueo, Lidia
Pérez García, Maria Jose
Giménez-Llort, Lydia
author Castillo-Mariqueo, Lidia
author_facet Castillo-Mariqueo, Lidia
Pérez García, Maria Jose
Giménez-Llort, Lydia
author_role author
author2 Pérez García, Maria Jose
Giménez-Llort, Lydia
author2_role author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Castillo-Mariqueo L, Giménez-Llort L] Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain. Departament de Psiquiatria i Medicina Forense, Escola de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Pérez-García MJ] Servei de Neurociència, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Alzheimer, Malaltia d' - Complicacions
Rates (Animals de laboratori)
Trastorns de la marxa
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Dementia::Alzheimer Disease
Other subheadings::Other subheadings::Other subheadings::/complications
ORGANISMS::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Eutheria::Rodentia::Muridae::Murinae::Mice
DISEASES::Nervous System Diseases::Neurologic Manifestations::Gait Disorders, Neurologic
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::demencia::enfermedad de Alzheimer
Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones
ORGANISMOS::Eukaryota::animales::Chordata::vertebrados::mamíferos::Eutheria::Rodentia::Muridae::Murinae::ratones
ENFERMEDADES::enfermedades del sistema nervioso::manifestaciones neurológicas::trastornos neurológicos de la marcha
topic Alzheimer, Malaltia d' - Complicacions
Rates (Animals de laboratori)
Trastorns de la marxa
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Dementia::Alzheimer Disease
Other subheadings::Other subheadings::Other subheadings::/complications
ORGANISMS::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Eutheria::Rodentia::Muridae::Murinae::Mice
DISEASES::Nervous System Diseases::Neurologic Manifestations::Gait Disorders, Neurologic
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::demencia::enfermedad de Alzheimer
Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones
ORGANISMOS::Eukaryota::animales::Chordata::vertebrados::mamíferos::Eutheria::Rodentia::Muridae::Murinae::ratones
ENFERMEDADES::enfermedades del sistema nervioso::manifestaciones neurológicas::trastornos neurológicos de la marcha
description Frailty; Muscular strength; Translational neuroscience
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/7545
url https://hdl.handle.net/11351/7545
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Biomedicines;9(10)
https://doi.org/10.3390/biomedicines9101365
info:eu-repo/grantAgreement/EC/H2020/737390
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869407416700895232
spelling Modeling Functional Limitations, Gait Impairments, and Muscle Pathology in Alzheimer’s Disease: Studies in the 3xTg-AD MiceCastillo-Mariqueo, LidiaPérez García, Maria JoseGiménez-Llort, LydiaAlzheimer, Malaltia d' - ComplicacionsRates (Animals de laboratori)Trastorns de la marxaDISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Dementia::Alzheimer DiseaseOther subheadings::Other subheadings::Other subheadings::/complicationsORGANISMS::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Eutheria::Rodentia::Muridae::Murinae::MiceDISEASES::Nervous System Diseases::Neurologic Manifestations::Gait Disorders, NeurologicENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::demencia::enfermedad de AlzheimerOtros calificadores::Otros calificadores::Otros calificadores::/complicacionesORGANISMOS::Eukaryota::animales::Chordata::vertebrados::mamíferos::Eutheria::Rodentia::Muridae::Murinae::ratonesENFERMEDADES::enfermedades del sistema nervioso::manifestaciones neurológicas::trastornos neurológicos de la marchaFrailty; Muscular strength; Translational neuroscienceFragilidad; Fuerza muscular; Neurociencia traslacionalFragilitat; Força muscular; Neurociència translacionalGait impairments in Alzheimer’s disease (AD) result from structural and functional deficiencies that generate limitations in the performance of activities and restrictions in individual’s biopsychosocial participation. In a translational way, we have used the conceptual framework proposed by the International Classification of Disability and Health Functioning (ICF) to classify and describe the functioning and disability on gait and exploratory activity in the 3xTg-AD animal model. We developed a behavioral observation method that allows us to differentiate qualitative parameters of psychomotor performance in animals’ gait, similar to the behavioral patterns observed in humans. The functional psychomotor evaluation allows measuring various dimensions of gait and exploratory activity at different stages of disease progression in dichotomy with aging. We included male 3xTg-AD mice and their non-transgenic counterpart (NTg) of 6, 12, and 16 months of age (n = 45). Here, we present the preliminary results. The 3xTg-AD mice show more significant functional impairment in gait and exploratory activity quantitative variables. The presence of movement limitations and muscle weakness mark the functional decline related to the disease severity stages that intensify with increasing age. Motor performance in 3xTg-AD is accompanied by a series of bizarre behaviors that interfere with the trajectory, which allows us to infer poor neurological control. Additionally, signs of physical frailty accompany the functional deterioration of these animals. The use of the ICF as a conceptual framework allows the functional status to be described, facilitating its interpretation and application in the rehabilitation of people with AD.This work was funded by 2017-SGR-1468 and UAB-GE-260408 to L.G.-L. The colony of 3xTg-AD mice is sustained by ArrestAD H2020 Fet-OPEN-1-2016-2017-737390, European Union’s Horizon 2020 research and innovation program under grant agreement No 737390 to L.G.-L. It also received financial support from Memorial Mercedes Llort Sender 2021/80/09241941.8.MDPIInstitut Català de la Salut[Castillo-Mariqueo L, Giménez-Llort L] Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain. Departament de Psiquiatria i Medicina Forense, Escola de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Pérez-García MJ] Servei de Neurociència, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/7545Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésBiomedicines;9(10)https://doi.org/10.3390/biomedicines9101365info:eu-repo/grantAgreement/EC/H2020/737390Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/75452026-06-12T09:38:37Z
score 15,811543

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