CYP1A2 genotype and the ergogenic effect of acute caffeine intake on muscular strength and endurance performance in trained individuals

10 p.

Detalles Bibliográficos
Autores: Montalvo Alonso, Juan Jesús|||0009-0003-6596-8258, Val Manzano, Marta Del, Martín Rivas, Iván, Ferragut Fiol, María Del Carmen|||0000-0003-3291-3042, Valadés Cerrato, David|||0000-0002-4709-2390, Pérez López, Alberto|||0000-0003-0220-6240
Tipo de recurso: artículo
Fecha de publicación:2026
País:España
Institución:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/68212
Acceso en línea:http://hdl.handle.net/10017/68212
https://dx.doi.org/10.1111/sms.70214
Access Level:acceso abierto
Palabra clave:Cafeine metabolism 
Ergogenic aid 
Muscular performance 
Resistance training 
Sex differences
Deportes
Biología y Biomedicina/Biología
Sports
Biology
id ES_4936c28ef35fc94ce8f0736639feccbf
oai_identifier_str oai:ebuah.uah.es:10017/68212
network_acronym_str ES
network_name_str España
repository_id_str
spelling CYP1A2 genotype and the ergogenic effect of acute caffeine intake on muscular strength and endurance performance in trained individualsMontalvo Alonso, Juan Jesús|||0009-0003-6596-8258Val Manzano, Marta DelMartín Rivas, IvánFerragut Fiol, María Del Carmen|||0000-0003-3291-3042Valadés Cerrato, David|||0000-0002-4709-2390Pérez López, Alberto|||0000-0003-0220-6240Cafeine metabolism Ergogenic aid Muscular performance Resistance training Sex differencesDeportesBiología y Biomedicina/BiologíaSportsBiology10 p.This study examined whether CYP1A2 (rs762551) genotype modulates the acute ergogenic effects of caffeine on muscular strength and endurance performance in resistance-trained men and women. Ninety-four resistance-trained participants (47 females, 47 males; 39 AA, 44 AC, 11 CC) completed a randomized, triple-blind, placebo-controlled, crossover trial. Participants ingested 3 mg/kg of caffeine or placebo before performing standardized bench press and back squat tests. Mean velocity was measured to assess strength performance against different loads (25%-90%) and muscular endurance during a single set performed to failure at 65% 1RM. Data were analyzed using ANCOVA with supplement, genotype, and sex as factors. Caffeine significantly improved strength and endurance performance across conditions (p < 0.01, ? 2 p = 0.077-0.294). Mean velocity increased by 4%-12% in AA and 3%-9% in AC individuals, particularly at 50%-90% 1RM, whereas CC carriers showed minor changes (? 4%). Supplement by genotype interaction was noted only at 90% 1RM in mean velocity (p < 0.05, ? 2 p = 0.094). In the muscular endurance test, mean velocity improved by 4%-6% in AA, 3%-4% in AC, and 2%-6% in CC. No sex differences or ergolytic effects were observed. Acute ingestion of 3 mg/kg caffeine enhances strength and endurance performance in resistance-trained men and women. Although CYP1A2 genotype did not alter the overall effect, benefits were greatest in AA, intermediate in AC, and minimal in CC carriers. These findings support low-dose caffeine as an effective and safe ergogenic aid in resistance training regardless of sex, with individual variability partly explained by genotype.Universidad de AlcaláiSanidad20262026-02-0220262026-02-0220272027-02-02journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/68212https://dx.doi.org/10.1111/sms.7021441627185reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/682122026-06-18T11:13:07Z
dc.title.none.fl_str_mv CYP1A2 genotype and the ergogenic effect of acute caffeine intake on muscular strength and endurance performance in trained individuals
title CYP1A2 genotype and the ergogenic effect of acute caffeine intake on muscular strength and endurance performance in trained individuals
spellingShingle CYP1A2 genotype and the ergogenic effect of acute caffeine intake on muscular strength and endurance performance in trained individuals
Montalvo Alonso, Juan Jesús|||0009-0003-6596-8258
Cafeine metabolism 
Ergogenic aid 
Muscular performance 
Resistance training 
Sex differences
Deportes
Biología y Biomedicina/Biología
Sports
Biology
title_short CYP1A2 genotype and the ergogenic effect of acute caffeine intake on muscular strength and endurance performance in trained individuals
title_full CYP1A2 genotype and the ergogenic effect of acute caffeine intake on muscular strength and endurance performance in trained individuals
title_fullStr CYP1A2 genotype and the ergogenic effect of acute caffeine intake on muscular strength and endurance performance in trained individuals
title_full_unstemmed CYP1A2 genotype and the ergogenic effect of acute caffeine intake on muscular strength and endurance performance in trained individuals
title_sort CYP1A2 genotype and the ergogenic effect of acute caffeine intake on muscular strength and endurance performance in trained individuals
dc.creator.none.fl_str_mv Montalvo Alonso, Juan Jesús|||0009-0003-6596-8258
Val Manzano, Marta Del
Martín Rivas, Iván
Ferragut Fiol, María Del Carmen|||0000-0003-3291-3042
Valadés Cerrato, David|||0000-0002-4709-2390
Pérez López, Alberto|||0000-0003-0220-6240
author Montalvo Alonso, Juan Jesús|||0009-0003-6596-8258
author_facet Montalvo Alonso, Juan Jesús|||0009-0003-6596-8258
Val Manzano, Marta Del
Martín Rivas, Iván
Ferragut Fiol, María Del Carmen|||0000-0003-3291-3042
Valadés Cerrato, David|||0000-0002-4709-2390
Pérez López, Alberto|||0000-0003-0220-6240
author_role author
author2 Val Manzano, Marta Del
Martín Rivas, Iván
Ferragut Fiol, María Del Carmen|||0000-0003-3291-3042
Valadés Cerrato, David|||0000-0002-4709-2390
Pérez López, Alberto|||0000-0003-0220-6240
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Cafeine metabolism 
Ergogenic aid 
Muscular performance 
Resistance training 
Sex differences
Deportes
Biología y Biomedicina/Biología
Sports
Biology
topic Cafeine metabolism 
Ergogenic aid 
Muscular performance 
Resistance training 
Sex differences
Deportes
Biología y Biomedicina/Biología
Sports
Biology
description 10 p.
publishDate 2026
dc.date.none.fl_str_mv 2026
2026-02-02
2026
2026-02-02
2027
2027-02-02
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/68212
https://dx.doi.org/10.1111/sms.70214
41627185
url http://hdl.handle.net/10017/68212
https://dx.doi.org/10.1111/sms.70214
identifier_str_mv 41627185
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869407408017637376
score 15.812429

Similares en LA Referencia