SND1 overexpression deregulates cholesterol homeostasis in hepatocellular carcinoma

SND1 is a multifunctional protein participating, among others, in gene transcription and mRNA metabolism. SND1 is overexpressed in cancer cells and promotes viability and tumourigenicity of hepatocellular carcinoma cells. This study shows that cholesterol synthesis is increased in SND1-overexpressin...

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Autores: Navarro Imaz, Hiart, Rueda Estévez, Yuri, Fresnedo Aranguren, María Olatz
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/75778
Acceso en línea:http://hdl.handle.net/10810/75778
Access Level:acceso abierto
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spelling SND1 overexpression deregulates cholesterol homeostasis in hepatocellular carcinomaNavarro Imaz, HiartRueda Estévez, YuriFresnedo Aranguren, María OlatzSND1 is a multifunctional protein participating, among others, in gene transcription and mRNA metabolism. SND1 is overexpressed in cancer cells and promotes viability and tumourigenicity of hepatocellular carcinoma cells. This study shows that cholesterol synthesis is increased in SND1-overexpressing hepatoma cells. Neither newly synthesised nor extracellularly supplied cholesterol are able to suppress this increase; however, inhibition of cholesterol esterification reverted the activated state of sterol-regulatory element-binding protein 2 (SREBP2) and cholesterogenesis. These results highlight SND1 as a potential regulator of cellular cholesterol distribution and homeostasis in hepatoma cells, and support the rationale for the therapeutic use of molecules that influence cholesterol management when SND1 is overexpressed.This research was supported by grants from the Basque Country Government (Saiotek SA-2010/00050, IT-336-10 and AE-2012-1-69), the University of the Basque Country UPV/EHU (UFI11/20) and the Jesús de Gangoiti Barrera Foundation. H.N.I. was recipient of research training fellowships from the Basque Country Government.Elsevier202520252016info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/75778reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://doi.org/10.1016/j.bbalip.2016.05.011info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/© 2016 Elsevier under CC BY-NC-ND licenseoai:addi.ehu.eus:10810/757782026-06-18T09:23:17Z
dc.title.none.fl_str_mv SND1 overexpression deregulates cholesterol homeostasis in hepatocellular carcinoma
title SND1 overexpression deregulates cholesterol homeostasis in hepatocellular carcinoma
spellingShingle SND1 overexpression deregulates cholesterol homeostasis in hepatocellular carcinoma
Navarro Imaz, Hiart
title_short SND1 overexpression deregulates cholesterol homeostasis in hepatocellular carcinoma
title_full SND1 overexpression deregulates cholesterol homeostasis in hepatocellular carcinoma
title_fullStr SND1 overexpression deregulates cholesterol homeostasis in hepatocellular carcinoma
title_full_unstemmed SND1 overexpression deregulates cholesterol homeostasis in hepatocellular carcinoma
title_sort SND1 overexpression deregulates cholesterol homeostasis in hepatocellular carcinoma
dc.creator.none.fl_str_mv Navarro Imaz, Hiart
Rueda Estévez, Yuri
Fresnedo Aranguren, María Olatz
author Navarro Imaz, Hiart
author_facet Navarro Imaz, Hiart
Rueda Estévez, Yuri
Fresnedo Aranguren, María Olatz
author_role author
author2 Rueda Estévez, Yuri
Fresnedo Aranguren, María Olatz
author2_role author
author
description SND1 is a multifunctional protein participating, among others, in gene transcription and mRNA metabolism. SND1 is overexpressed in cancer cells and promotes viability and tumourigenicity of hepatocellular carcinoma cells. This study shows that cholesterol synthesis is increased in SND1-overexpressing hepatoma cells. Neither newly synthesised nor extracellularly supplied cholesterol are able to suppress this increase; however, inhibition of cholesterol esterification reverted the activated state of sterol-regulatory element-binding protein 2 (SREBP2) and cholesterogenesis. These results highlight SND1 as a potential regulator of cellular cholesterol distribution and homeostasis in hepatoma cells, and support the rationale for the therapeutic use of molecules that influence cholesterol management when SND1 is overexpressed.
publishDate 2016
dc.date.none.fl_str_mv 2016
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/75778
url http://hdl.handle.net/10810/75778
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1016/j.bbalip.2016.05.011
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
© 2016 Elsevier under CC BY-NC-ND license
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
© 2016 Elsevier under CC BY-NC-ND license
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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