Characterization of interaction of magnetic nanoparticles with breast cancer cells

[Background] Different superparamagnetic iron oxide nanoparticles have been tested for their potential use in cancer treatment, as they enter into cells with high effectiveness, do not induce cytotoxicity, and are retained for relatively long periods of time inside the cells. We have analyzed the in...

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Detalles Bibliográficos
Autores: Calero, Macarena, Chiappi, Michele, Lázaro-Nogal, Ana, Rodríguez, María Josefa, Chichón, Francisco Javier, Crosbie-Staunton, Kieran, Prina-Mello, Adriele, Volkov, Yuri, Villanueva, Ángeles, Carrascosa, José L.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/125897
Acceso en línea:http://hdl.handle.net/10261/125897
Access Level:acceso abierto
Palabra clave:MCF-7 cells
Superparamagnetic iron oxide nanoparticles
Intracellular trafficking
Transmission electron microscopy
Cellular uptake
Endocytosis
Cytotoxicity
Descripción
Sumario:[Background] Different superparamagnetic iron oxide nanoparticles have been tested for their potential use in cancer treatment, as they enter into cells with high effectiveness, do not induce cytotoxicity, and are retained for relatively long periods of time inside the cells. We have analyzed the interaction, internalization and biocompatibility of dimercaptosuccinic acid-coated superparamagnetic iron oxide nanoparticles with an average diameter of 15 nm and negative surface charge in MCF-7 breast cancer cells.

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