Blood lipidome profiling reveals potential biomarkers linked to health and carcass quality traits in pigs

Background The modulation, activation, and differentiation of several immune cells is highly dependent on lipid metabolism. The objective of this study was to analyse the genetic determinism of the porcine plasma lipidome and its association to the animal immune capacity and production performance....

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Autores: Hernández-Banqué, Carles, Jové-Juncà, Teodor, Portero-Otin, Manel, Obis, Elia, González-Rodríguez, Olga, Ballester Devis, Maria, Quintanilla, Raquel
Formato: artículo
Fecha de publicación:2026
País:España
Recursos:Institut de Recerca i Tecnologia Agroalimentàries (IRTA)
Repositorio:IRTA Pubpro. Open Digital Archive
OAI Identifier:oai:dnet:irtapubpro__::fd03b16070ec05b7eff6907308a335ca
Acesso em linha:http://hdl.handle.net/20.500.12327/5098
https://doi.org/10.1186/s12711-026-01030-3
Access Level:acceso abierto
Palavra-chave:636
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oai_identifier_str oai:dnet:irtapubpro__::fd03b16070ec05b7eff6907308a335ca
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Blood lipidome profiling reveals potential biomarkers linked to health and carcass quality traits in pigs
title Blood lipidome profiling reveals potential biomarkers linked to health and carcass quality traits in pigs
spellingShingle Blood lipidome profiling reveals potential biomarkers linked to health and carcass quality traits in pigs
Hernández-Banqué, Carles
636
title_short Blood lipidome profiling reveals potential biomarkers linked to health and carcass quality traits in pigs
title_full Blood lipidome profiling reveals potential biomarkers linked to health and carcass quality traits in pigs
title_fullStr Blood lipidome profiling reveals potential biomarkers linked to health and carcass quality traits in pigs
title_full_unstemmed Blood lipidome profiling reveals potential biomarkers linked to health and carcass quality traits in pigs
title_sort Blood lipidome profiling reveals potential biomarkers linked to health and carcass quality traits in pigs
dc.creator.none.fl_str_mv Hernández-Banqué, Carles
Jové-Juncà, Teodor
Portero-Otin, Manel
Obis, Elia
González-Rodríguez, Olga
Ballester Devis, Maria
Quintanilla, Raquel
author Hernández-Banqué, Carles
author_facet Hernández-Banqué, Carles
Jové-Juncà, Teodor
Portero-Otin, Manel
Obis, Elia
González-Rodríguez, Olga
Ballester Devis, Maria
Quintanilla, Raquel
author_role author
author2 Jové-Juncà, Teodor
Portero-Otin, Manel
Obis, Elia
González-Rodríguez, Olga
Ballester Devis, Maria
Quintanilla, Raquel
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Producció Animal
Genètica i Millora Animal
dc.subject.none.fl_str_mv 636
topic 636
description Background The modulation, activation, and differentiation of several immune cells is highly dependent on lipid metabolism. The objective of this study was to analyse the genetic determinism of the porcine plasma lipidome and its association to the animal immune capacity and production performance. The analysis of the blood lipidome of 300 60-day-old Duroc pigs allowed semi-quantification of 982 circulating lipid molecules. We evaluated the genetic determinism of the lipidome abundances, as well as their phenotypic and genetic correlations with health, stress, and carcass phenotypes. Results Triacylglycerols were the most abundant lipid class among the plasma lipid features, followed by glycerophosphocholines, glycerophosphoethanolamines, diacylglycerols, and fatty acids/esters. Lipidome abundances showed low to moderate phenotypic correlations with the health and production traits, which clustered in two groups with opposite phenotypic correlation patterns with the lipidome. Mean heritability estimates for the circulating lipids abundance was generally low, but 184 lipid molecules showed significant heritability ranging between 0.25 and 0.85. At the genetic level, the percentage and phagocytic capacity of lymphocytes, the proportion of γδ T lymphocytes, and the cortisol concentration in hair were especially correlated with the lipidome, showing more than 200 significant genetic correlations with different lipidic compounds. Putative identification of associated metabolites by mass similarity revealed a large presence of phospholipids and glycerolipids among lipid molecules genetically correlated with immunity traits. Regarding production traits, fatness and lean meat measures showed an opposite pattern of genetic correlations with the porcine lipidome. Lipids positively correlated with fatness were mainly composed of diacyl- and triacyl-glycerides, while potential ceramides and phospholipids were more abundant among the lipids positively correlated with lean meat content at the genetic level. Conclusions Our results demonstrate a genetic determinism of the porcine blood lipidomic profile and suggest genetic correlations of the lipidome abundances with health and production performance phenotypes. We identify potential lipid biomarkers for assessing animal health and productivity.
publishDate 2026
dc.date.none.fl_str_mv 2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12327/5098
https://doi.org/10.1186/s12711-026-01030-3
url http://hdl.handle.net/20.500.12327/5098
https://doi.org/10.1186/s12711-026-01030-3
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Genetics Selection Evolution
MICINN/Programa Estatal de generación del conocimiento y fortalecimiento científico y tecnológico del sistema I+D+I y Programa Estatal de I+D+I orientada a los retos de la sociedad/PID2020-112677RB-C21/ES/FISIOLOGIA MOLECULAR DEL INMUNOMETABOLISMO EN PORCINO: BASES PARA LA SELECCION DE POBLACIONES MAS ROBUSTAS/
MICINN/Programa Estatal para impulsar la investigación científico-técnica y su transferencia/PID2023-148961OB-C21/ES/MEJORA GENETICA DE LA SALUD PORCINA: IDENTIFICACION Y VALIDACION DE BIOMARCADORES Y MODELOS PREDICTIVOS DE LA INMUNOCOMPETENCIA/
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 17
application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:IRTA Pubpro. Open Digital Archive
instname:Institut de Recerca i Tecnologia Agroalimentàries (IRTA)
instname_str Institut de Recerca i Tecnologia Agroalimentàries (IRTA)
reponame_str IRTA Pubpro. Open Digital Archive
collection IRTA Pubpro. Open Digital Archive
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Blood lipidome profiling reveals potential biomarkers linked to health and carcass quality traits in pigsHernández-Banqué, CarlesJové-Juncà, TeodorPortero-Otin, ManelObis, EliaGonzález-Rodríguez, OlgaBallester Devis, MariaQuintanilla, Raquel636Background The modulation, activation, and differentiation of several immune cells is highly dependent on lipid metabolism. The objective of this study was to analyse the genetic determinism of the porcine plasma lipidome and its association to the animal immune capacity and production performance. The analysis of the blood lipidome of 300 60-day-old Duroc pigs allowed semi-quantification of 982 circulating lipid molecules. We evaluated the genetic determinism of the lipidome abundances, as well as their phenotypic and genetic correlations with health, stress, and carcass phenotypes. Results Triacylglycerols were the most abundant lipid class among the plasma lipid features, followed by glycerophosphocholines, glycerophosphoethanolamines, diacylglycerols, and fatty acids/esters. Lipidome abundances showed low to moderate phenotypic correlations with the health and production traits, which clustered in two groups with opposite phenotypic correlation patterns with the lipidome. Mean heritability estimates for the circulating lipids abundance was generally low, but 184 lipid molecules showed significant heritability ranging between 0.25 and 0.85. At the genetic level, the percentage and phagocytic capacity of lymphocytes, the proportion of γδ T lymphocytes, and the cortisol concentration in hair were especially correlated with the lipidome, showing more than 200 significant genetic correlations with different lipidic compounds. Putative identification of associated metabolites by mass similarity revealed a large presence of phospholipids and glycerolipids among lipid molecules genetically correlated with immunity traits. Regarding production traits, fatness and lean meat measures showed an opposite pattern of genetic correlations with the porcine lipidome. Lipids positively correlated with fatness were mainly composed of diacyl- and triacyl-glycerides, while potential ceramides and phospholipids were more abundant among the lipids positively correlated with lean meat content at the genetic level. Conclusions Our results demonstrate a genetic determinism of the porcine blood lipidomic profile and suggest genetic correlations of the lipidome abundances with health and production performance phenotypes. We identify potential lipid biomarkers for assessing animal health and productivity.The study was funded by grant PID2020-112677RB-C21 and PID2023-148961OB-C21 awarded by MCIN/AEI/https://doi.org/10.13039/501100011033. C. Hernández-Banqué was supported by a FPI grant (PRE2021-097825) granted by the Spanish Ministry of Science and Innovation and T. Jové-Juncà was funded with an IRTA fellowship (CPI1221). Authors belong to the Consolidated Research Group “Sustainable animal husbandry” (AGAUR, reference 2021-SGR-01552).info:eu-repo/semantics/publishedVersionSpringer NatureProducció AnimalGenètica i Millora Animal202620262026info:eu-repo/semantics/article17application/pdfhttp://hdl.handle.net/20.500.12327/5098https://doi.org/10.1186/s12711-026-01030-3reponame:IRTA Pubpro. Open Digital Archiveinstname:Institut de Recerca i Tecnologia Agroalimentàries (IRTA)InglésGenetics Selection EvolutionMICINN/Programa Estatal de generación del conocimiento y fortalecimiento científico y tecnológico del sistema I+D+I y Programa Estatal de I+D+I orientada a los retos de la sociedad/PID2020-112677RB-C21/ES/FISIOLOGIA MOLECULAR DEL INMUNOMETABOLISMO EN PORCINO: BASES PARA LA SELECCION DE POBLACIONES MAS ROBUSTAS/MICINN/Programa Estatal para impulsar la investigación científico-técnica y su transferencia/PID2023-148961OB-C21/ES/MEJORA GENETICA DE LA SALUD PORCINA: IDENTIFICACION Y VALIDACION DE BIOMARCADORES Y MODELOS PREDICTIVOS DE LA INMUNOCOMPETENCIA/Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:irtapubpro__::fd03b16070ec05b7eff6907308a335ca2026-06-16T08:51:17Z
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