SSAO/VAP-1 in Cerebrovascular Disorders: A Potential Therapeutic Target for Stroke and Alzheimer’s Disease

Alzheimer’s disease; Inflammation; Vascular damage

Detalles Bibliográficos
Autores: Unzeta, Mercedes, Hernandez Guillamon, Maria Mar, Sun, Ping, Solé Piñol, Montserrat
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Departament de Salut de la Generalitat de Catalunya (DS)
Repositorio:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/7221
Acceso en línea:https://hdl.handle.net/11351/7221
Access Level:acceso abierto
Palabra clave:Malalties cerebrovasculars - Tractament
Amino oxidases - Metabolisme
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders
Other subheadings::Other subheadings::/therapy
CHEMICALS AND DRUGS::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Oxidoreductases Acting on CH-NH2 Group Donors::Amine Oxidase (Copper-Containing)
Other subheadings::Other subheadings::Other subheadings::/metabolism
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares
Otros calificadores::Otros calificadores::/terapia
COMPUESTOS QUÍMICOS Y DROGAS::enzimas y coenzimas::enzimas::oxidorreductasas::oxidorreductasas que actúan sobre donantes de grupos CH-NH2::amina oxidasa (con cobre)
Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo
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repository_id_str
spelling SSAO/VAP-1 in Cerebrovascular Disorders: A Potential Therapeutic Target for Stroke and Alzheimer’s DiseaseUnzeta, MercedesHernandez Guillamon, Maria MarSun, PingSolé Piñol, MontserratMalalties cerebrovasculars - TractamentAmino oxidases - MetabolismeDISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular DisordersOther subheadings::Other subheadings::/therapyCHEMICALS AND DRUGS::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Oxidoreductases Acting on CH-NH2 Group Donors::Amine Oxidase (Copper-Containing)Other subheadings::Other subheadings::Other subheadings::/metabolismENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovascularesOtros calificadores::Otros calificadores::/terapiaCOMPUESTOS QUÍMICOS Y DROGAS::enzimas y coenzimas::enzimas::oxidorreductasas::oxidorreductasas que actúan sobre donantes de grupos CH-NH2::amina oxidasa (con cobre)Otros calificadores::Otros calificadores::Otros calificadores::/metabolismoAlzheimer’s disease; Inflammation; Vascular damageMalaltia d'Alzheimer; Inflamació; Lesions vascularsEnfermedad de Alzheimer; Inflamación; Lesión vascularThe semicarbazide-sensitive amine oxidase (SSAO), also known as vascular adhesion protein-1 (VAP-1) or primary amine oxidase (PrAO), is a deaminating enzyme highly expressed in vessels that generates harmful products as a result of its enzymatic activity. As a multifunctional enzyme, it is also involved in inflammation through its ability to bind and promote the transmigration of circulating leukocytes into inflamed tissues. Inflammation is present in different systemic and cerebral diseases, including stroke and Alzheimer’s disease (AD). These pathologies show important affectations on cerebral vessels, together with increased SSAO levels. This review summarizes the main roles of SSAO/VAP-1 in human physiology and pathophysiology and discusses the mechanisms by which it can affect the onset and progression of both stroke and AD. As there is an evident interrelationship between stroke and AD, basically through the vascular system dysfunction, the possibility that SSAO/VAP-1 could be involved in the transition between these two pathologies is suggested. Hence, its inhibition is proposed to be an interesting therapeutical approach to the brain damage induced in these both cerebral pathologies.This research received no external funding. The Neurovascular Research Laboratory is part of the INVICTUS+ network, ISCIII, Spain (RD16/0019/0021).MDPIInstitut Català de la Salut[Unzeta M] Departament de Bioquímica i Biologia Molecular, Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Hernàndez-Guillamon M, Solé M] Laboratori de Recerca Neurovascular, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Sun P] Department of Neurology, Pittsburgh Institute of Brain Disorders and Recovery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USAVall d'Hebron Barcelona Hospital Campus202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/7221Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésInternational Journal of Molecular Sciences;22(7)https://doi.org/10.3390/ijms22073365info:eu-repo/grantAgreement/ES/PE2013-2016/RD16%2F0019%2F0021Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/72212026-06-12T09:38:37Z
dc.title.none.fl_str_mv SSAO/VAP-1 in Cerebrovascular Disorders: A Potential Therapeutic Target for Stroke and Alzheimer’s Disease
title SSAO/VAP-1 in Cerebrovascular Disorders: A Potential Therapeutic Target for Stroke and Alzheimer’s Disease
spellingShingle SSAO/VAP-1 in Cerebrovascular Disorders: A Potential Therapeutic Target for Stroke and Alzheimer’s Disease
Unzeta, Mercedes
Malalties cerebrovasculars - Tractament
Amino oxidases - Metabolisme
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders
Other subheadings::Other subheadings::/therapy
CHEMICALS AND DRUGS::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Oxidoreductases Acting on CH-NH2 Group Donors::Amine Oxidase (Copper-Containing)
Other subheadings::Other subheadings::Other subheadings::/metabolism
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares
Otros calificadores::Otros calificadores::/terapia
COMPUESTOS QUÍMICOS Y DROGAS::enzimas y coenzimas::enzimas::oxidorreductasas::oxidorreductasas que actúan sobre donantes de grupos CH-NH2::amina oxidasa (con cobre)
Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo
title_short SSAO/VAP-1 in Cerebrovascular Disorders: A Potential Therapeutic Target for Stroke and Alzheimer’s Disease
title_full SSAO/VAP-1 in Cerebrovascular Disorders: A Potential Therapeutic Target for Stroke and Alzheimer’s Disease
title_fullStr SSAO/VAP-1 in Cerebrovascular Disorders: A Potential Therapeutic Target for Stroke and Alzheimer’s Disease
title_full_unstemmed SSAO/VAP-1 in Cerebrovascular Disorders: A Potential Therapeutic Target for Stroke and Alzheimer’s Disease
title_sort SSAO/VAP-1 in Cerebrovascular Disorders: A Potential Therapeutic Target for Stroke and Alzheimer’s Disease
dc.creator.none.fl_str_mv Unzeta, Mercedes
Hernandez Guillamon, Maria Mar
Sun, Ping
Solé Piñol, Montserrat
author Unzeta, Mercedes
author_facet Unzeta, Mercedes
Hernandez Guillamon, Maria Mar
Sun, Ping
Solé Piñol, Montserrat
author_role author
author2 Hernandez Guillamon, Maria Mar
Sun, Ping
Solé Piñol, Montserrat
author2_role author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Unzeta M] Departament de Bioquímica i Biologia Molecular, Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Hernàndez-Guillamon M, Solé M] Laboratori de Recerca Neurovascular, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Sun P] Department of Neurology, Pittsburgh Institute of Brain Disorders and Recovery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Malalties cerebrovasculars - Tractament
Amino oxidases - Metabolisme
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders
Other subheadings::Other subheadings::/therapy
CHEMICALS AND DRUGS::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Oxidoreductases Acting on CH-NH2 Group Donors::Amine Oxidase (Copper-Containing)
Other subheadings::Other subheadings::Other subheadings::/metabolism
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares
Otros calificadores::Otros calificadores::/terapia
COMPUESTOS QUÍMICOS Y DROGAS::enzimas y coenzimas::enzimas::oxidorreductasas::oxidorreductasas que actúan sobre donantes de grupos CH-NH2::amina oxidasa (con cobre)
Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo
topic Malalties cerebrovasculars - Tractament
Amino oxidases - Metabolisme
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders
Other subheadings::Other subheadings::/therapy
CHEMICALS AND DRUGS::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Oxidoreductases Acting on CH-NH2 Group Donors::Amine Oxidase (Copper-Containing)
Other subheadings::Other subheadings::Other subheadings::/metabolism
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares
Otros calificadores::Otros calificadores::/terapia
COMPUESTOS QUÍMICOS Y DROGAS::enzimas y coenzimas::enzimas::oxidorreductasas::oxidorreductasas que actúan sobre donantes de grupos CH-NH2::amina oxidasa (con cobre)
Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo
description Alzheimer’s disease; Inflammation; Vascular damage
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/7221
url https://hdl.handle.net/11351/7221
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International Journal of Molecular Sciences;22(7)
https://doi.org/10.3390/ijms22073365
info:eu-repo/grantAgreement/ES/PE2013-2016/RD16%2F0019%2F0021
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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