The impact of rheumatoid arthritis on the risk of adverse events following joint replacement

To assess whether rheumatoid arthritis (RA) is associated with a greater risk of adverse events following total knee replacement (TKR) and total hip replacement (THR) than osteoarthritis (OA). Individuals with a diagnosis of RA or OA were identified using primary care records. TKR and THR following...

Descripción completa

Detalles Bibliográficos
Autores: Burn, Edward|||0000-0002-9286-1128, Edwards, Christopher J., Murray, David W., Silman, Alan, Cooper, Cyrus|||0000-0003-3510-0709, Arden, N. K.|||0000-0002-3452-3382, Prieto-Alhambra, Daniel|||0000-0002-3950-6346, Pinedo-Villanueva, Rafael|||0000-0002-4723-5128
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:238830
Acceso en línea:https://ddd.uab.cat/record/238830
https://dx.doi.org/urn:doi:10.2147/CLEP.S160347
Access Level:acceso abierto
Palabra clave:Hip
Knee
Arthroplasty
Osteoarthritis
Surgery
id ES_48d833aa47de6ea23e8a5b505efb5c7f
oai_identifier_str oai:ddd.uab.cat:238830
network_acronym_str ES
network_name_str España
repository_id_str
spelling The impact of rheumatoid arthritis on the risk of adverse events following joint replacementa real-world cohort studyBurn, Edward|||0000-0002-9286-1128Edwards, Christopher J.Murray, David W.Silman, AlanCooper, Cyrus|||0000-0003-3510-0709Arden, N. K.|||0000-0002-3452-3382Prieto-Alhambra, Daniel|||0000-0002-3950-6346Pinedo-Villanueva, Rafael|||0000-0002-4723-5128HipKneeArthroplastyOsteoarthritisSurgeryTo assess whether rheumatoid arthritis (RA) is associated with a greater risk of adverse events following total knee replacement (TKR) and total hip replacement (THR) than osteoarthritis (OA). Individuals with a diagnosis of RA or OA were identified using primary care records. TKR and THR following diagnosis were identified using linked hospital records. Myocardial infarction (MI), prosthetic joint infection (PJI), venous thromboembolism (VTE), and death were identified within 90 days following surgery, and revision procedures over 10 years following surgery. The impact of RA compared to OA on the risk for these adverse events was assessed using Cox proportional hazard models. Univariable models, with diagnosis as the only explanatory variable, and multivariable models, with age, gender, and year of surgery first added and then a measure of other comorbidities also included, were estimated. In all 20,763 individuals, with 10,260 TKR and 10,961 THR, were included in the analysis. Compared to those with OA, individuals with a diagnosis of RA had a greater incidence of MI over 90 days following TKR (OA: 0.28%, RA: 0.75%) and revision over 10 years following THR (OA: 5.55%, RA: 8.68%). Both of these differences were statistically significant with, for example, hazard ratios of 3.54 (1.44 to 8.73) for MI and 1.61 (1.06 to 2.46) for revision after controlling for age, gender, year of surgery, and other comorbidities. These findings suggest that, compared to individuals with OA, those with RA have an increased short-term risk of MI following TKR. While risk of MI remains below 1%, this does underline the importance of the management of cardiovascular risk factors for those with RA. RA was also associated with an increased long-term risk of revision following THR, which strengthens the argument for investing in therapies which may prevent the need for joint replacement.Universitat Autònoma de Barcelona 22018-01-0120182018-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/238830https://dx.doi.org/urn:doi:10.2147/CLEP.S160347reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2388302026-06-06T12:50:31Z
dc.title.none.fl_str_mv The impact of rheumatoid arthritis on the risk of adverse events following joint replacement
a real-world cohort study
title The impact of rheumatoid arthritis on the risk of adverse events following joint replacement
spellingShingle The impact of rheumatoid arthritis on the risk of adverse events following joint replacement
Burn, Edward|||0000-0002-9286-1128
Hip
Knee
Arthroplasty
Osteoarthritis
Surgery
title_short The impact of rheumatoid arthritis on the risk of adverse events following joint replacement
title_full The impact of rheumatoid arthritis on the risk of adverse events following joint replacement
title_fullStr The impact of rheumatoid arthritis on the risk of adverse events following joint replacement
title_full_unstemmed The impact of rheumatoid arthritis on the risk of adverse events following joint replacement
title_sort The impact of rheumatoid arthritis on the risk of adverse events following joint replacement
dc.creator.none.fl_str_mv Burn, Edward|||0000-0002-9286-1128
Edwards, Christopher J.
Murray, David W.
Silman, Alan
Cooper, Cyrus|||0000-0003-3510-0709
Arden, N. K.|||0000-0002-3452-3382
Prieto-Alhambra, Daniel|||0000-0002-3950-6346
Pinedo-Villanueva, Rafael|||0000-0002-4723-5128
author Burn, Edward|||0000-0002-9286-1128
author_facet Burn, Edward|||0000-0002-9286-1128
Edwards, Christopher J.
Murray, David W.
Silman, Alan
Cooper, Cyrus|||0000-0003-3510-0709
Arden, N. K.|||0000-0002-3452-3382
Prieto-Alhambra, Daniel|||0000-0002-3950-6346
Pinedo-Villanueva, Rafael|||0000-0002-4723-5128
author_role author
author2 Edwards, Christopher J.
Murray, David W.
Silman, Alan
Cooper, Cyrus|||0000-0003-3510-0709
Arden, N. K.|||0000-0002-3452-3382
Prieto-Alhambra, Daniel|||0000-0002-3950-6346
Pinedo-Villanueva, Rafael|||0000-0002-4723-5128
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Hip
Knee
Arthroplasty
Osteoarthritis
Surgery
topic Hip
Knee
Arthroplasty
Osteoarthritis
Surgery
description To assess whether rheumatoid arthritis (RA) is associated with a greater risk of adverse events following total knee replacement (TKR) and total hip replacement (THR) than osteoarthritis (OA). Individuals with a diagnosis of RA or OA were identified using primary care records. TKR and THR following diagnosis were identified using linked hospital records. Myocardial infarction (MI), prosthetic joint infection (PJI), venous thromboembolism (VTE), and death were identified within 90 days following surgery, and revision procedures over 10 years following surgery. The impact of RA compared to OA on the risk for these adverse events was assessed using Cox proportional hazard models. Univariable models, with diagnosis as the only explanatory variable, and multivariable models, with age, gender, and year of surgery first added and then a measure of other comorbidities also included, were estimated. In all 20,763 individuals, with 10,260 TKR and 10,961 THR, were included in the analysis. Compared to those with OA, individuals with a diagnosis of RA had a greater incidence of MI over 90 days following TKR (OA: 0.28%, RA: 0.75%) and revision over 10 years following THR (OA: 5.55%, RA: 8.68%). Both of these differences were statistically significant with, for example, hazard ratios of 3.54 (1.44 to 8.73) for MI and 1.61 (1.06 to 2.46) for revision after controlling for age, gender, year of surgery, and other comorbidities. These findings suggest that, compared to individuals with OA, those with RA have an increased short-term risk of MI following TKR. While risk of MI remains below 1%, this does underline the importance of the management of cardiovascular risk factors for those with RA. RA was also associated with an increased long-term risk of revision following THR, which strengthens the argument for investing in therapies which may prevent the need for joint replacement.
publishDate 2018
dc.date.none.fl_str_mv 2
2018-01-01
2018
2018-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/238830
https://dx.doi.org/urn:doi:10.2147/CLEP.S160347
url https://ddd.uab.cat/record/238830
https://dx.doi.org/urn:doi:10.2147/CLEP.S160347
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869407385654657024
score 15,300719

Similares en LA Referencia