A systematic review and secondary data analysis of the interactions between the serotonin transporter 5-HTTLPR polymorphism and environmental and psychological factors in eating disorders

Objectives: to summarize and synthesize the growing gene x environment (GxE) research investigating the promoter region of the serotonin transporter gene (5-HTTLPR) in the eating disorders (ED) field, and overcome the common limitation of low sample size, by undertaking a systematic review followed...

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Autores: Rozenblat, Vanja, Ong, Deborah, Fuller-Tyszkiewicz, Matthew, Akkermann, Kirsti, Collier, David, Engels, Rutger C. M. E., Fernández Aranda, Fernando, Harro, Jaanus, Homberg, Judith R., Karwautz, Andreas, Kiive, Evelyn, Klump, Kelly L., Larson, Christine L., Racine, Sarah E., Richardson, Jodie, Steiger, Howard, Stoltenberg, Scott F., Van Strien, Tatjana, Wagner, Gudrun, Treasure, Janet, Krug, Isabel
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2017
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/133093
Acceso en línea:https://hdl.handle.net/2445/133093
Access Level:acceso abierto
Palabra clave:Bulímia
Trastorns de la conducta alimentària
Metaanàlisi
Ressenyes sistemàtiques (Investigació mèdica)
Bulimia
Eating disorders
Meta-analysis
Systematic reviews (Medical research)
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spelling A systematic review and secondary data analysis of the interactions between the serotonin transporter 5-HTTLPR polymorphism and environmental and psychological factors in eating disordersRozenblat, VanjaOng, DeborahFuller-Tyszkiewicz, MatthewAkkermann, KirstiCollier, DavidEngels, Rutger C. M. E.Fernández Aranda, FernandoHarro, JaanusHomberg, Judith R.Karwautz, AndreasKiive, EvelynKlump, Kelly L.Larson, Christine L.Racine, Sarah E.Richardson, JodieSteiger, HowardStoltenberg, Scott F.Van Strien, TatjanaWagner, GudrunTreasure, JanetKrug, IsabelBulímiaTrastorns de la conducta alimentàriaMetaanàlisiRessenyes sistemàtiques (Investigació mèdica)BulimiaEating disordersMeta-analysisSystematic reviews (Medical research)Objectives: to summarize and synthesize the growing gene x environment (GxE) research investigating the promoter region of the serotonin transporter gene (5-HTTLPR) in the eating disorders (ED) field, and overcome the common limitation of low sample size, by undertaking a systematic review followed by a secondary data meta-analysis of studies identified by the review. Method: a systematic review of articles using PsycINFO, PubMed, and EMBASE was undertaken to identify studies investigating the interaction between 5-HTTLPR and an environmental or psychological factor, with an ED-related outcome variable. Seven studies were identified by the systematic review, with complete data sets of five community (n = 1750, 64.5% female) and two clinical (n = 426,100% female) samples combined to perform four secondary-data analyses: 5-I-M1PR x Traumatic Life Events to predict ED status (n = 909), 5-HTTLPR x Sexual and Physical Abuse to predict bulimic symptoms (n = 1097), 5-HTTLPR x Depression to predict bulimic symptoms (n = 1256), and 5-HTTLPRx Impulsiveness to predict disordered eating (n = 1149). Results: under a multiplicative model, the low function (s) allele of 5-HTTLPR interacted with traumatic life events and experiencing both sexual and physical abuse (but not only one) to predict increased likelihood of an ED and bulimic symptoms, respectively. However, under an additive model there was also an interaction between sexual and physical abuse considered independently and 5-HTTLPR, and no interaction with traumatic life events. No other GxE interactions were significant. Conclusion: early promising results should be followed-up with continued cross-institutional collaboration in order to achieve the large sample sizes necessary for genetic research.Elsevier Ltd2019201920172019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion11 p.application/pdfhttps://hdl.handle.net/2445/133093Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1016/j.jpsychires.2016.09.023Journal of Psychiatric Research, 2017, vol. 84, p. 62-72https://doi.org/10.1016/j.jpsychires.2016.09.023cc-by-nc-nd (c) Elsevier Ltd, 2017http://creativecommons.org/licenses/by-nc-nd/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1330932026-05-29T05:05:01Z
dc.title.none.fl_str_mv A systematic review and secondary data analysis of the interactions between the serotonin transporter 5-HTTLPR polymorphism and environmental and psychological factors in eating disorders
title A systematic review and secondary data analysis of the interactions between the serotonin transporter 5-HTTLPR polymorphism and environmental and psychological factors in eating disorders
spellingShingle A systematic review and secondary data analysis of the interactions between the serotonin transporter 5-HTTLPR polymorphism and environmental and psychological factors in eating disorders
Rozenblat, Vanja
Bulímia
Trastorns de la conducta alimentària
Metaanàlisi
Ressenyes sistemàtiques (Investigació mèdica)
Bulimia
Eating disorders
Meta-analysis
Systematic reviews (Medical research)
title_short A systematic review and secondary data analysis of the interactions between the serotonin transporter 5-HTTLPR polymorphism and environmental and psychological factors in eating disorders
title_full A systematic review and secondary data analysis of the interactions between the serotonin transporter 5-HTTLPR polymorphism and environmental and psychological factors in eating disorders
title_fullStr A systematic review and secondary data analysis of the interactions between the serotonin transporter 5-HTTLPR polymorphism and environmental and psychological factors in eating disorders
title_full_unstemmed A systematic review and secondary data analysis of the interactions between the serotonin transporter 5-HTTLPR polymorphism and environmental and psychological factors in eating disorders
title_sort A systematic review and secondary data analysis of the interactions between the serotonin transporter 5-HTTLPR polymorphism and environmental and psychological factors in eating disorders
dc.creator.none.fl_str_mv Rozenblat, Vanja
Ong, Deborah
Fuller-Tyszkiewicz, Matthew
Akkermann, Kirsti
Collier, David
Engels, Rutger C. M. E.
Fernández Aranda, Fernando
Harro, Jaanus
Homberg, Judith R.
Karwautz, Andreas
Kiive, Evelyn
Klump, Kelly L.
Larson, Christine L.
Racine, Sarah E.
Richardson, Jodie
Steiger, Howard
Stoltenberg, Scott F.
Van Strien, Tatjana
Wagner, Gudrun
Treasure, Janet
Krug, Isabel
author Rozenblat, Vanja
author_facet Rozenblat, Vanja
Ong, Deborah
Fuller-Tyszkiewicz, Matthew
Akkermann, Kirsti
Collier, David
Engels, Rutger C. M. E.
Fernández Aranda, Fernando
Harro, Jaanus
Homberg, Judith R.
Karwautz, Andreas
Kiive, Evelyn
Klump, Kelly L.
Larson, Christine L.
Racine, Sarah E.
Richardson, Jodie
Steiger, Howard
Stoltenberg, Scott F.
Van Strien, Tatjana
Wagner, Gudrun
Treasure, Janet
Krug, Isabel
author_role author
author2 Ong, Deborah
Fuller-Tyszkiewicz, Matthew
Akkermann, Kirsti
Collier, David
Engels, Rutger C. M. E.
Fernández Aranda, Fernando
Harro, Jaanus
Homberg, Judith R.
Karwautz, Andreas
Kiive, Evelyn
Klump, Kelly L.
Larson, Christine L.
Racine, Sarah E.
Richardson, Jodie
Steiger, Howard
Stoltenberg, Scott F.
Van Strien, Tatjana
Wagner, Gudrun
Treasure, Janet
Krug, Isabel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Bulímia
Trastorns de la conducta alimentària
Metaanàlisi
Ressenyes sistemàtiques (Investigació mèdica)
Bulimia
Eating disorders
Meta-analysis
Systematic reviews (Medical research)
topic Bulímia
Trastorns de la conducta alimentària
Metaanàlisi
Ressenyes sistemàtiques (Investigació mèdica)
Bulimia
Eating disorders
Meta-analysis
Systematic reviews (Medical research)
description Objectives: to summarize and synthesize the growing gene x environment (GxE) research investigating the promoter region of the serotonin transporter gene (5-HTTLPR) in the eating disorders (ED) field, and overcome the common limitation of low sample size, by undertaking a systematic review followed by a secondary data meta-analysis of studies identified by the review. Method: a systematic review of articles using PsycINFO, PubMed, and EMBASE was undertaken to identify studies investigating the interaction between 5-HTTLPR and an environmental or psychological factor, with an ED-related outcome variable. Seven studies were identified by the systematic review, with complete data sets of five community (n = 1750, 64.5% female) and two clinical (n = 426,100% female) samples combined to perform four secondary-data analyses: 5-I-M1PR x Traumatic Life Events to predict ED status (n = 909), 5-HTTLPR x Sexual and Physical Abuse to predict bulimic symptoms (n = 1097), 5-HTTLPR x Depression to predict bulimic symptoms (n = 1256), and 5-HTTLPRx Impulsiveness to predict disordered eating (n = 1149). Results: under a multiplicative model, the low function (s) allele of 5-HTTLPR interacted with traumatic life events and experiencing both sexual and physical abuse (but not only one) to predict increased likelihood of an ED and bulimic symptoms, respectively. However, under an additive model there was also an interaction between sexual and physical abuse considered independently and 5-HTTLPR, and no interaction with traumatic life events. No other GxE interactions were significant. Conclusion: early promising results should be followed-up with continued cross-institutional collaboration in order to achieve the large sample sizes necessary for genetic research.
publishDate 2017
dc.date.none.fl_str_mv 2017
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/133093
url https://hdl.handle.net/2445/133093
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.jpsychires.2016.09.023
Journal of Psychiatric Research, 2017, vol. 84, p. 62-72
https://doi.org/10.1016/j.jpsychires.2016.09.023
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Elsevier Ltd, 2017
http://creativecommons.org/licenses/by-nc-nd/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Elsevier Ltd, 2017
http://creativecommons.org/licenses/by-nc-nd/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ltd
publisher.none.fl_str_mv Elsevier Ltd
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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