Association between chronic immune-mediated inflammatory diseases and cardiovascular risk

Objective: To examine the association between chronic immune-mediated diseases (rheumatoid arthritis, systemic lupus erythematosus or the following chronic immune-mediated inflammatory diagnoses groups: inflammatory bowel diseases, inflammatory polyarthropathies, systemic connective tissue disorders...

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Autores: Baena Díez, José Miguel, García Gil, Maria, Comas Cufí, Marc, Ramos, Rafel, Prieto Alhambra, Daniel, Salvador González, Betlem, Elosua, Roberto, Degano, Irene R., Peñafiel, Judith, Grau, Maria
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/178169
Acceso en línea:https://hdl.handle.net/2445/178169
Access Level:acceso abierto
Palabra clave:Malalties cardiovasculars
Inflamació
Cardiovascular diseases
Inflammation
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spelling Association between chronic immune-mediated inflammatory diseases and cardiovascular riskBaena Díez, José MiguelGarcía Gil, MariaComas Cufí, MarcRamos, RafelPrieto Alhambra, DanielSalvador González, BetlemElosua, RobertoDegano, Irene R.Peñafiel, JudithGrau, MariaMalalties cardiovascularsInflamacióCardiovascular diseasesInflammationObjective: To examine the association between chronic immune-mediated diseases (rheumatoid arthritis, systemic lupus erythematosus or the following chronic immune-mediated inflammatory diagnoses groups: inflammatory bowel diseases, inflammatory polyarthropathies, systemic connective tissue disorders and spondylopathies) and the 6-year coronary artery disease, stroke, cardiovascular disease incidence and overall mortality; and to estimate the population attributable fractions for all four end-points for each chronic immune-mediated inflammatory disease. Methods: Cohort study of individuals aged 35-85 years, with no history of cardiovascular disease from Catalonia (Spain). The coded diagnoses of chronic immune-mediated diseases and cardiovascular diseases were ascertained and registered using validated codes, and date of death was obtained from administrative data. Cox regression models for each outcome according to exposure were fitted to estimate HRs in two models 1 : after adjustment for sex, age, cardiovascular risk factors and 2 further adjusted for drug use. Population attributable fractions were estimated for each exposure. Results: Data were collected from 991 546 participants. The risk of cardiovascular disease was increased in systemic connective tissue disorders (model 1: HR=1.38 (95% CI 1.21 to 1.57) and model 2: HR=1.31 (95% CI 1.15 to 1.49)), rheumatoid arthritis (HR=1.43 (95% CI 1.26 to 1.62) and HR=1.31 (95% CI 1.15 to 1.49)) and inflammatory bowel diseases (HR=1.18 (95% CI 1.06 to 1.32) and HR=1.12 (95% CI 1.01 to 1.25)). The effect of anti-inflammatory treatment was significant in all instances (HR=1.50 (95% CI 1.24 to 1.81); HR=1.47 (95% CI 1.23 to 1.75); HR=1.43 (95% CI 1.19 to 1.73), respectively). The population attributable fractions for all three disorders were 13.4%, 15.7% and 10.7%, respectively. Conclusion: Systemic connective tissue disorders and rheumatoid arthritis conferred the highest cardiovascular risk and population impact, followed by inflammatory bowel diseases.BMJ Publishing Group & British Cardiovascular Society2021202120182021info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion28 p.application/pdfhttps://hdl.handle.net/2445/178169Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1136/heartjnl-2017-311279Heart, 2018, vol. 104, num. 2, p. 119-126https://doi.org/10.1136/heartjnl-2017-311279(c) Baena Díez, José Miguel et al., 2018info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1781692026-05-29T05:05:01Z
dc.title.none.fl_str_mv Association between chronic immune-mediated inflammatory diseases and cardiovascular risk
title Association between chronic immune-mediated inflammatory diseases and cardiovascular risk
spellingShingle Association between chronic immune-mediated inflammatory diseases and cardiovascular risk
Baena Díez, José Miguel
Malalties cardiovasculars
Inflamació
Cardiovascular diseases
Inflammation
title_short Association between chronic immune-mediated inflammatory diseases and cardiovascular risk
title_full Association between chronic immune-mediated inflammatory diseases and cardiovascular risk
title_fullStr Association between chronic immune-mediated inflammatory diseases and cardiovascular risk
title_full_unstemmed Association between chronic immune-mediated inflammatory diseases and cardiovascular risk
title_sort Association between chronic immune-mediated inflammatory diseases and cardiovascular risk
dc.creator.none.fl_str_mv Baena Díez, José Miguel
García Gil, Maria
Comas Cufí, Marc
Ramos, Rafel
Prieto Alhambra, Daniel
Salvador González, Betlem
Elosua, Roberto
Degano, Irene R.
Peñafiel, Judith
Grau, Maria
author Baena Díez, José Miguel
author_facet Baena Díez, José Miguel
García Gil, Maria
Comas Cufí, Marc
Ramos, Rafel
Prieto Alhambra, Daniel
Salvador González, Betlem
Elosua, Roberto
Degano, Irene R.
Peñafiel, Judith
Grau, Maria
author_role author
author2 García Gil, Maria
Comas Cufí, Marc
Ramos, Rafel
Prieto Alhambra, Daniel
Salvador González, Betlem
Elosua, Roberto
Degano, Irene R.
Peñafiel, Judith
Grau, Maria
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malalties cardiovasculars
Inflamació
Cardiovascular diseases
Inflammation
topic Malalties cardiovasculars
Inflamació
Cardiovascular diseases
Inflammation
description Objective: To examine the association between chronic immune-mediated diseases (rheumatoid arthritis, systemic lupus erythematosus or the following chronic immune-mediated inflammatory diagnoses groups: inflammatory bowel diseases, inflammatory polyarthropathies, systemic connective tissue disorders and spondylopathies) and the 6-year coronary artery disease, stroke, cardiovascular disease incidence and overall mortality; and to estimate the population attributable fractions for all four end-points for each chronic immune-mediated inflammatory disease. Methods: Cohort study of individuals aged 35-85 years, with no history of cardiovascular disease from Catalonia (Spain). The coded diagnoses of chronic immune-mediated diseases and cardiovascular diseases were ascertained and registered using validated codes, and date of death was obtained from administrative data. Cox regression models for each outcome according to exposure were fitted to estimate HRs in two models 1 : after adjustment for sex, age, cardiovascular risk factors and 2 further adjusted for drug use. Population attributable fractions were estimated for each exposure. Results: Data were collected from 991 546 participants. The risk of cardiovascular disease was increased in systemic connective tissue disorders (model 1: HR=1.38 (95% CI 1.21 to 1.57) and model 2: HR=1.31 (95% CI 1.15 to 1.49)), rheumatoid arthritis (HR=1.43 (95% CI 1.26 to 1.62) and HR=1.31 (95% CI 1.15 to 1.49)) and inflammatory bowel diseases (HR=1.18 (95% CI 1.06 to 1.32) and HR=1.12 (95% CI 1.01 to 1.25)). The effect of anti-inflammatory treatment was significant in all instances (HR=1.50 (95% CI 1.24 to 1.81); HR=1.47 (95% CI 1.23 to 1.75); HR=1.43 (95% CI 1.19 to 1.73), respectively). The population attributable fractions for all three disorders were 13.4%, 15.7% and 10.7%, respectively. Conclusion: Systemic connective tissue disorders and rheumatoid arthritis conferred the highest cardiovascular risk and population impact, followed by inflammatory bowel diseases.
publishDate 2018
dc.date.none.fl_str_mv 2018
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/178169
url https://hdl.handle.net/2445/178169
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1136/heartjnl-2017-311279
Heart, 2018, vol. 104, num. 2, p. 119-126
https://doi.org/10.1136/heartjnl-2017-311279
dc.rights.none.fl_str_mv (c) Baena Díez, José Miguel et al., 2018
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Baena Díez, José Miguel et al., 2018
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 28 p.
application/pdf
dc.publisher.none.fl_str_mv BMJ Publishing Group & British Cardiovascular Society
publisher.none.fl_str_mv BMJ Publishing Group & British Cardiovascular Society
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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