Lack of effects of Resolvin D1 after spinal cord injury in mice

Inflammation is a fundamental component of the body's response to injury or infection and is responsible for restoring tissue homeostasis and starting the wound healing process. To avoid excessive tissue damage, it is important to efficiently resolve inflammation once it is no longer necessary....

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Authors: Francos Quijorna, Isaac|||0000-0003-2514-4206, López-González, Néstor, Caro-Canton, Marc|||0009-0007-3421-8875, Sánchez-Fernández, Alba, Hernández-Mir, Gerard|||0000-0002-8934-4875, López Vales, Rubén|||0000-0001-7615-9550
Format: article
Publication Date:2025
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:311787
Online Access:https://ddd.uab.cat/record/311787
https://dx.doi.org/urn:doi:10.1016/j.expneurol.2025.115226
Access Level:Open access
Keyword:Resolvin D1
Maresin 1Inflammation
Inflammatory resolution
Neuroprotection
Spinal cord injury
MicroArray
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spelling Lack of effects of Resolvin D1 after spinal cord injury in miceFrancos Quijorna, Isaac|||0000-0003-2514-4206López-González, NéstorCaro-Canton, Marc|||0009-0007-3421-8875Sánchez-Fernández, AlbaHernández-Mir, Gerard|||0000-0002-8934-4875López Vales, Rubén|||0000-0001-7615-9550Resolvin D1Maresin 1InflammationInflammatory resolutionNeuroprotectionSpinal cord injuryMicroArrayInflammation is a fundamental component of the body's response to injury or infection and is responsible for restoring tissue homeostasis and starting the wound healing process. To avoid excessive tissue damage, it is important to efficiently resolve inflammation once it is no longer necessary. In recent years, the discovery of pro-resolving lipid mediators derived from polyunsaturated fatty acids, such as Resolvin D1 (RvD1), has shed light on the resolution of inflammation. However, the impact of RvD1 on Spinal Cord Injury (SCI) remains unexplored. In this study, we provide direct evidence that the administration of RvD1 for one week after SCI fails to enhance resolution of inflammation and does not improve functional and histological outcomes. Our transcriptomic analysis reveals that RvD1 does not modulate inflammatory response pathways in the injured spinal cord but leads to significant changes in the expression of genes related to ribosomal function and extracellular matrix pathways. Unlike SCI, RvD1 treatment ameliorated neurological deficits in experimental autoimmune encephalomyelitis. Our findings represent the first report demonstrating that RvD1 treatment does not exert therapeutic actions in the context of SCI and suggest that this pro-resolving agonist may exert therapeutic actions in certain but not in all conditions involving an inflammatory component. 22025-01-0120252025-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/311787https://dx.doi.org/urn:doi:10.1016/j.expneurol.2025.115226reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-120267RBAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2023-152474OB-100open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3117872026-06-06T12:50:31Z
dc.title.none.fl_str_mv Lack of effects of Resolvin D1 after spinal cord injury in mice
title Lack of effects of Resolvin D1 after spinal cord injury in mice
spellingShingle Lack of effects of Resolvin D1 after spinal cord injury in mice
Francos Quijorna, Isaac|||0000-0003-2514-4206
Resolvin D1
Maresin 1Inflammation
Inflammatory resolution
Neuroprotection
Spinal cord injury
MicroArray
title_short Lack of effects of Resolvin D1 after spinal cord injury in mice
title_full Lack of effects of Resolvin D1 after spinal cord injury in mice
title_fullStr Lack of effects of Resolvin D1 after spinal cord injury in mice
title_full_unstemmed Lack of effects of Resolvin D1 after spinal cord injury in mice
title_sort Lack of effects of Resolvin D1 after spinal cord injury in mice
dc.creator.none.fl_str_mv Francos Quijorna, Isaac|||0000-0003-2514-4206
López-González, Néstor
Caro-Canton, Marc|||0009-0007-3421-8875
Sánchez-Fernández, Alba
Hernández-Mir, Gerard|||0000-0002-8934-4875
López Vales, Rubén|||0000-0001-7615-9550
author Francos Quijorna, Isaac|||0000-0003-2514-4206
author_facet Francos Quijorna, Isaac|||0000-0003-2514-4206
López-González, Néstor
Caro-Canton, Marc|||0009-0007-3421-8875
Sánchez-Fernández, Alba
Hernández-Mir, Gerard|||0000-0002-8934-4875
López Vales, Rubén|||0000-0001-7615-9550
author_role author
author2 López-González, Néstor
Caro-Canton, Marc|||0009-0007-3421-8875
Sánchez-Fernández, Alba
Hernández-Mir, Gerard|||0000-0002-8934-4875
López Vales, Rubén|||0000-0001-7615-9550
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Resolvin D1
Maresin 1Inflammation
Inflammatory resolution
Neuroprotection
Spinal cord injury
MicroArray
topic Resolvin D1
Maresin 1Inflammation
Inflammatory resolution
Neuroprotection
Spinal cord injury
MicroArray
description Inflammation is a fundamental component of the body's response to injury or infection and is responsible for restoring tissue homeostasis and starting the wound healing process. To avoid excessive tissue damage, it is important to efficiently resolve inflammation once it is no longer necessary. In recent years, the discovery of pro-resolving lipid mediators derived from polyunsaturated fatty acids, such as Resolvin D1 (RvD1), has shed light on the resolution of inflammation. However, the impact of RvD1 on Spinal Cord Injury (SCI) remains unexplored. In this study, we provide direct evidence that the administration of RvD1 for one week after SCI fails to enhance resolution of inflammation and does not improve functional and histological outcomes. Our transcriptomic analysis reveals that RvD1 does not modulate inflammatory response pathways in the injured spinal cord but leads to significant changes in the expression of genes related to ribosomal function and extracellular matrix pathways. Unlike SCI, RvD1 treatment ameliorated neurological deficits in experimental autoimmune encephalomyelitis. Our findings represent the first report demonstrating that RvD1 treatment does not exert therapeutic actions in the context of SCI and suggest that this pro-resolving agonist may exert therapeutic actions in certain but not in all conditions involving an inflammatory component.
publishDate 2025
dc.date.none.fl_str_mv 2
2025-01-01
2025
2025-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/311787
https://dx.doi.org/urn:doi:10.1016/j.expneurol.2025.115226
url https://ddd.uab.cat/record/311787
https://dx.doi.org/urn:doi:10.1016/j.expneurol.2025.115226
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-120267RB
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2023-152474OB-100
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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