Efficacy and safety study of allogeneic equine umbilical cord derived mesenchymal stem cells ( EUC-MSCs) for the treatment of clinical symptomatology associated with mild to moderate degenerative joint disease (osteoarthritis) in horses under field conditions
Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Farmacología y terapéutica. Fecha de lectura: 22-11-2019
| Autor: | |
|---|---|
| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/690438 |
| Acceso en línea: | http://hdl.handle.net/10486/690438 |
| Access Level: | acceso abierto |
| Palabra clave: | Células madre mesenquimales - Tesis doctorales Farmacia |
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| dc.title.none.fl_str_mv |
Efficacy and safety study of allogeneic equine umbilical cord derived mesenchymal stem cells ( EUC-MSCs) for the treatment of clinical symptomatology associated with mild to moderate degenerative joint disease (osteoarthritis) in horses under field conditions |
| title |
Efficacy and safety study of allogeneic equine umbilical cord derived mesenchymal stem cells ( EUC-MSCs) for the treatment of clinical symptomatology associated with mild to moderate degenerative joint disease (osteoarthritis) in horses under field conditions |
| spellingShingle |
Efficacy and safety study of allogeneic equine umbilical cord derived mesenchymal stem cells ( EUC-MSCs) for the treatment of clinical symptomatology associated with mild to moderate degenerative joint disease (osteoarthritis) in horses under field conditions Pradera Muñoz, Almudena Células madre mesenquimales - Tesis doctorales Farmacia |
| title_short |
Efficacy and safety study of allogeneic equine umbilical cord derived mesenchymal stem cells ( EUC-MSCs) for the treatment of clinical symptomatology associated with mild to moderate degenerative joint disease (osteoarthritis) in horses under field conditions |
| title_full |
Efficacy and safety study of allogeneic equine umbilical cord derived mesenchymal stem cells ( EUC-MSCs) for the treatment of clinical symptomatology associated with mild to moderate degenerative joint disease (osteoarthritis) in horses under field conditions |
| title_fullStr |
Efficacy and safety study of allogeneic equine umbilical cord derived mesenchymal stem cells ( EUC-MSCs) for the treatment of clinical symptomatology associated with mild to moderate degenerative joint disease (osteoarthritis) in horses under field conditions |
| title_full_unstemmed |
Efficacy and safety study of allogeneic equine umbilical cord derived mesenchymal stem cells ( EUC-MSCs) for the treatment of clinical symptomatology associated with mild to moderate degenerative joint disease (osteoarthritis) in horses under field conditions |
| title_sort |
Efficacy and safety study of allogeneic equine umbilical cord derived mesenchymal stem cells ( EUC-MSCs) for the treatment of clinical symptomatology associated with mild to moderate degenerative joint disease (osteoarthritis) in horses under field conditions |
| dc.creator.none.fl_str_mv |
Pradera Muñoz, Almudena |
| author |
Pradera Muñoz, Almudena |
| author_facet |
Pradera Muñoz, Almudena |
| author_role |
author |
| dc.contributor.none.fl_str_mv |
Cañas Fernández, Noelia Departamento de Farmacología Facultad de Medicina |
| dc.subject.none.fl_str_mv |
Células madre mesenquimales - Tesis doctorales Farmacia |
| topic |
Células madre mesenquimales - Tesis doctorales Farmacia |
| description |
Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Farmacología y terapéutica. Fecha de lectura: 22-11-2019 |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 2019-11-22 |
| dc.type.none.fl_str_mv |
doctoral thesis http://purl.org/coar/resource_type/c_db06 NA http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
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info:eu-repo/semantics/doctoralThesis |
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doctoralThesis |
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http://hdl.handle.net/10486/690438 |
| url |
http://hdl.handle.net/10486/690438 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
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open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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reponame:Biblos-e Archivo. Repositorio Institucional de la UAM instname:Universidad Autónoma de Madrid |
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Universidad Autónoma de Madrid |
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Biblos-e Archivo. Repositorio Institucional de la UAM |
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Biblos-e Archivo. Repositorio Institucional de la UAM |
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1869407376600203264 |
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Efficacy and safety study of allogeneic equine umbilical cord derived mesenchymal stem cells ( EUC-MSCs) for the treatment of clinical symptomatology associated with mild to moderate degenerative joint disease (osteoarthritis) in horses under field conditionsPradera Muñoz, AlmudenaCélulas madre mesenquimales - Tesis doctoralesFarmaciaTesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Farmacología y terapéutica. Fecha de lectura: 22-11-2019Esta tesis tiene embargado el acceso al texto completo hasta el 22-05-2021Osteoarthritis (OA) is one of the equine diseases with the greatest economic impact in the industry. Responsible for 60% of lameness, OA is considered one of the main causes of premature abandonment of sports life in horses. Despite its high economic impact on both direct and indirect costs, few new treatments have been developed for the treatment of equine OA in recent decades. Non-steroidal anti-inflammatory and / or corticosteroid accompanied by nutritional supplements are the most commonly used conventional treatments in the equine clinic, however, conventional treatments are associated with positive doping in sport horses and can have important medium-long term side effects. The objective of this work was to demonstrate the safety and efficacy of a new product of advanced therapies based on Equine Umbilical Cord Mesenchymal Stem Cells (EUC-MSC) as treatment of equine OA. To achieve the objective a superiority, controlled, blind, randomized and multicentre clinical study, has been designed and conduct following the European and Good Clinical Practices guidelines (VICH 9- GCP). In addition to the main objective, the present work has deep in the knowledge of the EUCMSC efficacy, for that different epidemiological covariates such as age, chronicity of symptoms, the type of joint affected or the degree of sporting level of the animal has been analysed in order to discover if there were specific equine populations where the EUC-MSC are not effective. Likewise, a comparative study on the efficacy-safety-price balance of the treatment with EUCMSC has been made in comparison with conventional treatments in order to discover if EUCMSC can be considered a real therapeutic alternative. The present study has demonstrated a robust efficacy of EUC-MSC in the reduction of lameness in horses affected by OA. 72% of the horses treated with EUC-MSC showed a reduction in the level of lameness, presenting non-lameness or an inconsistent lameness, allowing the horses to return to the same level of sport activity than after the injury. The study of epidemiological covariates found that the efficacy of EUC-MSC is consistent, not being affected by epidemiological factors such as age, chronicity of symptoms or the degree of sports activity. Finally, it has been established that in a comparative efficacy-safety-price chart, EUC-MSC represents a real alternative to conventional treatments thanks to its long efficacy and few adverse effectsLa Osteoartrosis (OA) equina es una de las enfermedades equinas de mayor impacto económico en la industria. Responsable del 60% de las cojeras equinas, la OA es considerada una de las principales causas de abandono prematuro de la vida deportiva en équidos. A pesar de su alto impacto económico tanto en costes directos como indirectos, pocos tratamientos nuevos han sido autorizados para el tratamiento de la OA equina en las últimas décadas. Los tratamientos farmacológicos especialmente antiinflamatorios no esteroides y/o corticoides acompañados de complementos nutricionales son los tratamientos convencionales más utilizados en la clínica equina, sin embargo, los tratamientos convencionales están asociados a doping en caballos de competición y pueden suponer importantes efectos secundarios a medio-largo plazo. El objetivo de este trabajo es demostrar la seguridad y eficacia de un nuevo producto de terapias avanzadas basado en células madre mesenquimales de cordón umbilical equino (EUC-MSC) en el tratamiento de la OA equina. Para conseguir el objetivo un estudio clínico de superioridad, controlado, ciego, aleatorizado y multicéntrico, ha sido diseñado siguiendo las guías y directrices europeas de Buenas Prácticas Clínicas (VICH 9 guidelines). Adicionalmente al objetivo principal, el presente trabajo ha tratado de estudiar ampliamente la eficacia de las EUC-MSC teniendo en cuenta diferentes covariables epidemiológicas como la edad, la cronicidad de los síntomas, el tipo de articulación afectada o el grado de nivel deportivo del animal; con el fin de descubrir si había poblaciones especificas donde las EUCMSC no son tan efectivas. Así mismo, se ha hecho un estudio comparativo sobre el balance eficacia-seguridad-precio del tratamiento con EUC-MSC en comparación con los tratamientos convencionales con el fin de descubrir si efectivamente las EUC-MSC pueden suponer una alternativa terapéutica. El presente estudio ha demostrado una sólida eficacia de las EUC-MSC en la reducción de la cojera en caballos afectados por OA. El 72% de los caballos tratados con EUC-MSC presentaron una reducción del nivel de cojera, quedando sin cojera o con una cojera inconsistente, permitiendo que los caballos volviesen a su mismo nivel de actividad deportiva posterior a la lesión. El estudio de covariables epidemiológicas descubrió que la eficacia de las EUC-MSC es consistente no viéndose afectadas por factores epidemiológicos como la edad, la cronicidad de los síntomas o el grado de actividad deportiva. Por último, se ha establecido que en una comparativa eficacia-seguridad-precio las EUC-MSC representan una alternativa real a los tratamientos convencionales gracias a su larga eficacia y escasos efectos adversosCañas Fernández, NoeliaDepartamento de FarmacologíaFacultad de Medicina20192019-11-22doctoral thesishttp://purl.org/coar/resource_type/c_db06NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/doctoralThesisapplication/pdfhttp://hdl.handle.net/10486/690438reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6904382026-06-23T12:46:27Z |
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15.301603 |