Reduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix-intraventricular hemorrhage

Cervell; Investigació pediàtrica

Detalles Bibliográficos
Autores: Fernández de Gamarra‑Oca, Lexuri, Zubiaurre‑Elorza, Leire, Junqué, Carme, Solana, Elisabeth, Soria‑Pastor, Sara, Vázquez Méndez, Josefa Élida, Poca Pastor, Ma Antonia, Delgado Alvarez, Ignacio, Macaya Ruíz, Alfons
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/6192
Acceso en línea:https://hdl.handle.net/11351/6192
Access Level:acceso abierto
Palabra clave:Hipocamp
Trastorns de la memòria
Infants prematurs - Malalties
DISEASES::Congenital, Hereditary, and Neonatal Diseases and Abnormalities::Infant, Newborn, Diseases
ANATOMY::Nervous System::Central Nervous System::Brain::Limbic System::Hippocampus
PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurocognitive Disorders::Cognition Disorders
ENFERMEDADES::enfermedades y anomalías neonatales congénitas y hereditarias::enfermedades del recién nacido
ANATOMÍA::sistema nervioso::sistema nervioso central::encéfalo::sistema límbico::hipocampo
PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos neurocognitivos::trastornos cognitivos
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network_name_str España
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dc.title.none.fl_str_mv Reduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix-intraventricular hemorrhage
title Reduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix-intraventricular hemorrhage
spellingShingle Reduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix-intraventricular hemorrhage
Fernández de Gamarra‑Oca, Lexuri
Hipocamp
Trastorns de la memòria
Infants prematurs - Malalties
DISEASES::Congenital, Hereditary, and Neonatal Diseases and Abnormalities::Infant, Newborn, Diseases
ANATOMY::Nervous System::Central Nervous System::Brain::Limbic System::Hippocampus
PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurocognitive Disorders::Cognition Disorders
ENFERMEDADES::enfermedades y anomalías neonatales congénitas y hereditarias::enfermedades del recién nacido
ANATOMÍA::sistema nervioso::sistema nervioso central::encéfalo::sistema límbico::hipocampo
PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos neurocognitivos::trastornos cognitivos
title_short Reduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix-intraventricular hemorrhage
title_full Reduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix-intraventricular hemorrhage
title_fullStr Reduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix-intraventricular hemorrhage
title_full_unstemmed Reduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix-intraventricular hemorrhage
title_sort Reduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix-intraventricular hemorrhage
dc.creator.none.fl_str_mv Fernández de Gamarra‑Oca, Lexuri
Zubiaurre‑Elorza, Leire
Junqué, Carme
Solana, Elisabeth
Soria‑Pastor, Sara
Vázquez Méndez, Josefa Élida
Poca Pastor, Ma Antonia
Delgado Alvarez, Ignacio
Macaya Ruíz, Alfons
author Fernández de Gamarra‑Oca, Lexuri
author_facet Fernández de Gamarra‑Oca, Lexuri
Zubiaurre‑Elorza, Leire
Junqué, Carme
Solana, Elisabeth
Soria‑Pastor, Sara
Vázquez Méndez, Josefa Élida
Poca Pastor, Ma Antonia
Delgado Alvarez, Ignacio
Macaya Ruíz, Alfons
author_role author
author2 Zubiaurre‑Elorza, Leire
Junqué, Carme
Solana, Elisabeth
Soria‑Pastor, Sara
Vázquez Méndez, Josefa Élida
Poca Pastor, Ma Antonia
Delgado Alvarez, Ignacio
Macaya Ruíz, Alfons
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Fernández de Gamarra-Oca L, Zubiaurre-Elorza L] Department of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Bilbao, Basque Country, Spain. [Junqué C] Medical Psychology Unit, Department of Medicine, Institute of Neuroscience, University of Barcelona, Barcelona, Catalonia, Spain. Biomedical Research Networking Center on Neurodegenerative Diseases (CIBERNED), Hospital Clinic, Barcelona, Catalonia, Spain. Institute of Biomedical Research August Pi I Sunyer (IDIBAPS), Barcelona, Catalonia, Spain. [Solana E] Institute of Biomedical Research August Pi I Sunyer (IDIBAPS), Barcelona, Catalonia, Spain. Center of Neuroimmunology, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clinic, Barcelona, Catalonia, Spain. [Soria-Pastor S] Department of Psychiatry, Consorci Sanitari del Maresme, Hospital of Mataró, Mataró, Catalonia, Spain. [Vázquez É, Delgado I] Servei de Radiologia Pediàtrica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Macaya A] Grup de Recerca en Neurologia Pediàtrica, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Poca MA] Servei de Neurocirurgia. Neurotraumatology and Neurosurgery Research Unit, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Hipocamp
Trastorns de la memòria
Infants prematurs - Malalties
DISEASES::Congenital, Hereditary, and Neonatal Diseases and Abnormalities::Infant, Newborn, Diseases
ANATOMY::Nervous System::Central Nervous System::Brain::Limbic System::Hippocampus
PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurocognitive Disorders::Cognition Disorders
ENFERMEDADES::enfermedades y anomalías neonatales congénitas y hereditarias::enfermedades del recién nacido
ANATOMÍA::sistema nervioso::sistema nervioso central::encéfalo::sistema límbico::hipocampo
PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos neurocognitivos::trastornos cognitivos
topic Hipocamp
Trastorns de la memòria
Infants prematurs - Malalties
DISEASES::Congenital, Hereditary, and Neonatal Diseases and Abnormalities::Infant, Newborn, Diseases
ANATOMY::Nervous System::Central Nervous System::Brain::Limbic System::Hippocampus
PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurocognitive Disorders::Cognition Disorders
ENFERMEDADES::enfermedades y anomalías neonatales congénitas y hereditarias::enfermedades del recién nacido
ANATOMÍA::sistema nervioso::sistema nervioso central::encéfalo::sistema límbico::hipocampo
PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos neurocognitivos::trastornos cognitivos
description Cervell; Investigació pediàtrica
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/6192
url https://hdl.handle.net/11351/6192
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Scientific Reports;11(1)
https://www.nature.com/articles/s41598-021-81802-7
info:eu-repo/grantAgreement/ES/PE2013-2016/PSI2017-83657-P
info:eu-repo/grantAgreement/ES/1PN/2004-2007
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Reduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix-intraventricular hemorrhageFernández de Gamarra‑Oca, LexuriZubiaurre‑Elorza, LeireJunqué, CarmeSolana, ElisabethSoria‑Pastor, SaraVázquez Méndez, Josefa ÉlidaPoca Pastor, Ma AntoniaDelgado Alvarez, IgnacioMacaya Ruíz, AlfonsHipocampTrastorns de la memòriaInfants prematurs - MalaltiesDISEASES::Congenital, Hereditary, and Neonatal Diseases and Abnormalities::Infant, Newborn, DiseasesANATOMY::Nervous System::Central Nervous System::Brain::Limbic System::HippocampusPSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurocognitive Disorders::Cognition DisordersENFERMEDADES::enfermedades y anomalías neonatales congénitas y hereditarias::enfermedades del recién nacidoANATOMÍA::sistema nervioso::sistema nervioso central::encéfalo::sistema límbico::hipocampoPSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos neurocognitivos::trastornos cognitivosCervell; Investigació pediàtricaCerebro; Investigación pediátricaBrain; Paediatric researchPreterm newborns with germinal matrix-intraventricular hemorrhage (GM-IVH) are at a higher risk of evidencing neurodevelopmental alterations. Present study aimed to explore the long-term effects that GM-IVH have on hippocampal subfields, and their correlates with memory. The sample consisted of 58 participants, including 36 preterm-born (16 with GM-IVH and 20 without neonatal brain injury), and 22 full-term children aged between 6 and 15 years old. All participants underwent a cognitive assessment and magnetic resonance imaging study. GM-IVH children evidenced lower scores in Full Intelligence Quotient and memory measures compared to their low-risk preterm and full-term peers. High-risk preterm children with GM-IVH evidenced significantly lower total hippocampal volumes bilaterally and hippocampal subfield volumes compared to both low-risk preterm and full-term groups. Finally, significant positive correlations between memory and hippocampal subfield volumes were only found in preterm participants together; memory and the right CA-field correlation remained significant after Bonferroni correction was applied (p = .002). In conclusion, memory alterations and both global and regional volumetric reductions in the hippocampus were found to be specifically related to a preterm sample with GM-IVH. Nevertheless, results also suggest that prematurity per se has a long-lasting impact on the association between the right CA-field volume and memory during childhood.This study was funded by the Spanish Ministry of Science, Innovation and Universities [P.I.: L. Zubiaurre-Elorza (PSI2017-83657-P)]. L. Fernández de Gamarra-Oca, S. Soria-Pastor, R. L. Zubiaurre-Elorza, and E. Solana hold fellowships from the Basque Government (PRE_2019_1_0105), the Spanish Ministry of Education and Science (AP2005-0047) and (AP2008-0935) and the Vall d’Hebron Research Institute, Universitat Autònoma de Barcelona respectively. We would like to extend special thanks to the families and the children who participated in this study.Nature ResearchInstitut Català de la Salut[Fernández de Gamarra-Oca L, Zubiaurre-Elorza L] Department of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Bilbao, Basque Country, Spain. [Junqué C] Medical Psychology Unit, Department of Medicine, Institute of Neuroscience, University of Barcelona, Barcelona, Catalonia, Spain. Biomedical Research Networking Center on Neurodegenerative Diseases (CIBERNED), Hospital Clinic, Barcelona, Catalonia, Spain. Institute of Biomedical Research August Pi I Sunyer (IDIBAPS), Barcelona, Catalonia, Spain. [Solana E] Institute of Biomedical Research August Pi I Sunyer (IDIBAPS), Barcelona, Catalonia, Spain. Center of Neuroimmunology, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clinic, Barcelona, Catalonia, Spain. [Soria-Pastor S] Department of Psychiatry, Consorci Sanitari del Maresme, Hospital of Mataró, Mataró, Catalonia, Spain. [Vázquez É, Delgado I] Servei de Radiologia Pediàtrica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Macaya A] Grup de Recerca en Neurologia Pediàtrica, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Poca MA] Servei de Neurocirurgia. Neurotraumatology and Neurosurgery Research Unit, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, SpainVall d'Hebron Barcelona Hospital Campus202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/6192Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésScientific Reports;11(1)https://www.nature.com/articles/s41598-021-81802-7info:eu-repo/grantAgreement/ES/PE2013-2016/PSI2017-83657-Pinfo:eu-repo/grantAgreement/ES/1PN/2004-2007Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/61922026-05-29T05:05:01Z
score 15,81155

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