Extracellular Vesicles in Hepatobiliary Malignancies

Primary hepatobiliary malignancies include a heterogeneous group of cancers with dismal prognosis, among which hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), and hepatoblastoma (HB) stand out. These tumors mainly arise from the malignant transformation of hepatocytes, cholangiocytes (bile...

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Autores: Lapitz Dambolenea, Ainhoa, Arbelaiz Cossio, Ander, Olaizola Rebe, Paula, Aranburu, Aitziber, Bujanda Fernández de Pierola, Luis, Perugorria Montiel, María Jesús, Bañales Asurmendi, Jesús María
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/30474
Acceso en línea:http://hdl.handle.net/10810/30474
Access Level:acceso abierto
Palabra clave:extracellular vesicles
hepatocellular carcinoma
cholangiocarcinoma
hepatoblastoma
pathogenesis
therapy
diagnosis
epithelial-mesenchymal transition
hepatocellular-carcinoma cells
dendritic cells
cancer-cell
intrahepatic cholangiocarcinoma
multivesicular endosomes
tumor microenvironment
pancreatic-cancer
mediated transfer
serum exosomes
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repository_id_str
spelling Extracellular Vesicles in Hepatobiliary MalignanciesLapitz Dambolenea, AinhoaArbelaiz Cossio, AnderOlaizola Rebe, PaulaAranburu, AitziberBujanda Fernández de Pierola, LuisPerugorria Montiel, María JesúsBañales Asurmendi, Jesús Maríaextracellular vesicleshepatocellular carcinomacholangiocarcinomahepatoblastomapathogenesistherapydiagnosisepithelial-mesenchymal transitionhepatocellular-carcinoma cellsdendritic cellscancer-cellintrahepatic cholangiocarcinomamultivesicular endosomestumor microenvironmentpancreatic-cancermediated transferserum exosomesPrimary hepatobiliary malignancies include a heterogeneous group of cancers with dismal prognosis, among which hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), and hepatoblastoma (HB) stand out. These tumors mainly arise from the malignant transformation of hepatocytes, cholangiocytes (bile duct epithelial cells) or hepatoblasts (embryonic liver progenitor cells), respectively. Early diagnosis, prognosis prediction and effective therapies are still a utopia for these diseases. Extracellular vesicles (EVs) are small membrane-enclosed spheres secreted by cells and present in biological fluids. They contain multiple types of biomolecules, such as proteins, RNA, DNA, metabolites and lipids, which make them a potential source of biomarkers as well as regulators of human pathobiology. In this review, the role of EVs in the pathogenesis of hepatobiliary cancers and their potential usefulness as disease biomarkers are highlighted. Moreover, the therapeutic value of EV regulation is discussed and future directions on basic and clinical research are indicated.Spanish Ministries of Economy and Competitiveness [JB (FIS PI12/00380, FIS PI15/01132 and Miguel Servet Programme CON14/00129); MP (FIS PI14/00399, FIS PI17/00022) and Ramon y Cajal Programme RYC-2015-17755] cofinanced by Fondo Europeo de Desarrollo Regional (FEDER); ISCIII [CIBERehd: JB, LB, and MP], Spain; Diputacion Foral Gipuzkoa (JB: DFG15/010, DFG16/004), BIOEF (Basque Foundation for Innovation and Health Research: EiTB Maratoia BIO15/CA/016/BD to JB); Department of Health of the Basque Country (JB: 2013111173 and 2017111010; MP: 2015111100), and AECC Scientific Foundation (JB). AL and PO were funded by the Basque Government.Frontiers Media201820182018info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/30474reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/grantAgreement/MINECO/RYC-2015-17755/https://www.frontiersin.org/articles/10.3389/fimmu.2018.02270/fullinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/2018 Lapitz, Arbelaiz, Olaizola, Aranburu, Bujanda, Perugorria and Banales. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Atribución 3.0 Españaoai:addi.ehu.eus:10810/304742026-06-18T09:23:17Z
dc.title.none.fl_str_mv Extracellular Vesicles in Hepatobiliary Malignancies
title Extracellular Vesicles in Hepatobiliary Malignancies
spellingShingle Extracellular Vesicles in Hepatobiliary Malignancies
Lapitz Dambolenea, Ainhoa
extracellular vesicles
hepatocellular carcinoma
cholangiocarcinoma
hepatoblastoma
pathogenesis
therapy
diagnosis
epithelial-mesenchymal transition
hepatocellular-carcinoma cells
dendritic cells
cancer-cell
intrahepatic cholangiocarcinoma
multivesicular endosomes
tumor microenvironment
pancreatic-cancer
mediated transfer
serum exosomes
title_short Extracellular Vesicles in Hepatobiliary Malignancies
title_full Extracellular Vesicles in Hepatobiliary Malignancies
title_fullStr Extracellular Vesicles in Hepatobiliary Malignancies
title_full_unstemmed Extracellular Vesicles in Hepatobiliary Malignancies
title_sort Extracellular Vesicles in Hepatobiliary Malignancies
dc.creator.none.fl_str_mv Lapitz Dambolenea, Ainhoa
Arbelaiz Cossio, Ander
Olaizola Rebe, Paula
Aranburu, Aitziber
Bujanda Fernández de Pierola, Luis
Perugorria Montiel, María Jesús
Bañales Asurmendi, Jesús María
author Lapitz Dambolenea, Ainhoa
author_facet Lapitz Dambolenea, Ainhoa
Arbelaiz Cossio, Ander
Olaizola Rebe, Paula
Aranburu, Aitziber
Bujanda Fernández de Pierola, Luis
Perugorria Montiel, María Jesús
Bañales Asurmendi, Jesús María
author_role author
author2 Arbelaiz Cossio, Ander
Olaizola Rebe, Paula
Aranburu, Aitziber
Bujanda Fernández de Pierola, Luis
Perugorria Montiel, María Jesús
Bañales Asurmendi, Jesús María
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv extracellular vesicles
hepatocellular carcinoma
cholangiocarcinoma
hepatoblastoma
pathogenesis
therapy
diagnosis
epithelial-mesenchymal transition
hepatocellular-carcinoma cells
dendritic cells
cancer-cell
intrahepatic cholangiocarcinoma
multivesicular endosomes
tumor microenvironment
pancreatic-cancer
mediated transfer
serum exosomes
topic extracellular vesicles
hepatocellular carcinoma
cholangiocarcinoma
hepatoblastoma
pathogenesis
therapy
diagnosis
epithelial-mesenchymal transition
hepatocellular-carcinoma cells
dendritic cells
cancer-cell
intrahepatic cholangiocarcinoma
multivesicular endosomes
tumor microenvironment
pancreatic-cancer
mediated transfer
serum exosomes
description Primary hepatobiliary malignancies include a heterogeneous group of cancers with dismal prognosis, among which hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), and hepatoblastoma (HB) stand out. These tumors mainly arise from the malignant transformation of hepatocytes, cholangiocytes (bile duct epithelial cells) or hepatoblasts (embryonic liver progenitor cells), respectively. Early diagnosis, prognosis prediction and effective therapies are still a utopia for these diseases. Extracellular vesicles (EVs) are small membrane-enclosed spheres secreted by cells and present in biological fluids. They contain multiple types of biomolecules, such as proteins, RNA, DNA, metabolites and lipids, which make them a potential source of biomarkers as well as regulators of human pathobiology. In this review, the role of EVs in the pathogenesis of hepatobiliary cancers and their potential usefulness as disease biomarkers are highlighted. Moreover, the therapeutic value of EV regulation is discussed and future directions on basic and clinical research are indicated.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/30474
url http://hdl.handle.net/10810/30474
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MINECO/RYC-2015-17755/
https://www.frontiersin.org/articles/10.3389/fimmu.2018.02270/full
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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