Detection of PrPSc in lung and mammary gland is favored by the presence of Visna/maedi virus lesions in naturally coinfected sheep

There are few reports on the pathogenesis of scrapie (Sc) and Visna/maedi virus (VMV) coinfections. The aim of this work was to study in vivo as well as post mortem both diseases in 91 sheep. Diagnosis of Sc and VMV infections allowed the distribution of animals into five groups according to the pre...

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Autores: Salazar, Eider, Monleón, Eva, Bolea, Rosa, Acín, Cristina, Pérez, Marta María, Álvarez, Neila, Leginagoikoa, Iratxe, Juste, Ramón, Minguijón, Esmeralda, Reina Arias, Ramsés, Glaría Ezquer, Idoia, Berriatua, Eduardo, Andrés Cara, Damián de, Badiola, Juan José, Amorena Zabalza, Beatriz, Luján, Lluís
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2010
País:España
Recursos:Universidad Pública de Navarra
Repositório:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/31529
Acesso em linha:https://hdl.handle.net/2454/31529
Access Level:Acceso aberto
Palavra-chave:Visna/maedi
Scrapie
Sheep
Coinfection
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spelling Detection of PrPSc in lung and mammary gland is favored by the presence of Visna/maedi virus lesions in naturally coinfected sheepSalazar, EiderMonleón, EvaBolea, RosaAcín, CristinaPérez, Marta MaríaÁlvarez, NeilaLeginagoikoa, IratxeJuste, RamónMinguijón, EsmeraldaReina Arias, RamsésGlaría Ezquer, IdoiaBerriatua, EduardoAndrés Cara, Damián deBadiola, Juan JoséAmorena Zabalza, BeatrizLuján, LluísVisna/maediScrapieSheepCoinfectionThere are few reports on the pathogenesis of scrapie (Sc) and Visna/maedi virus (VMV) coinfections. The aim of this work was to study in vivo as well as post mortem both diseases in 91 sheep. Diagnosis of Sc and VMV infections allowed the distribution of animals into five groups according to the presence (+) or absence ( ) of infection by Sc and VMV: Sc /VMV , Sc /VMV+, Sc+/VMV and Sc+/ VMV+. The latter was divided into two subgroups, with and without VMV-induced lymphoid follicle hyperplasia (LFH), respectively. In both the lung and mammary gland, PrPSc deposits were found in the germinal center of hyperplasic lymphoid follicles in the subgroup of Sc+/VMV+ having VMV-induced LFH. This detection was always associated with (and likely preceded by) PrPSc observation in the corresponding lymph nodes. No PrPSc was found in other VMV-associated lesions. Animals suffering from scrapie had a statistically significantly lower mean age than the scrapie free animals at the time of death, with no apparent VMV influence. ARQ/ARQ genotype was the most abundant among the 91 ewes and the most frequent in scrapie-affected sheep. VMV infection does not seem to influence the scrapie risk group distribution among animals from the five groups established in this work. Altogether, these data indicate that certain VMVinduced lesions can favor PrPSc deposits in Sc non-target organs such as the lung and the mammary gland, making this coinfection an interesting field that warrants further research for a better comprehension of the pathogenesis of both diseases.This work has been funded by a grant of Ministerio de Ciencia e Innovación (ref. AGL2007-66874-C04 GAN). E. Salazar was a PhD student funded by grant B073/2006 from Gobierno de Aragón.EDP SciencesIdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutua2010info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2454/31529reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglés© The authors, INRA/EDP Sciences, 2010. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial License, which permits unrestricted use, distribution, and reproduction in any noncommercial medium, provided the original work is properly cited.https://creativecommons.org/licenses/by-nc/3.0/info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/315292026-06-17T12:41:47Z
dc.title.none.fl_str_mv Detection of PrPSc in lung and mammary gland is favored by the presence of Visna/maedi virus lesions in naturally coinfected sheep
title Detection of PrPSc in lung and mammary gland is favored by the presence of Visna/maedi virus lesions in naturally coinfected sheep
spellingShingle Detection of PrPSc in lung and mammary gland is favored by the presence of Visna/maedi virus lesions in naturally coinfected sheep
Salazar, Eider
Visna/maedi
Scrapie
Sheep
Coinfection
title_short Detection of PrPSc in lung and mammary gland is favored by the presence of Visna/maedi virus lesions in naturally coinfected sheep
title_full Detection of PrPSc in lung and mammary gland is favored by the presence of Visna/maedi virus lesions in naturally coinfected sheep
title_fullStr Detection of PrPSc in lung and mammary gland is favored by the presence of Visna/maedi virus lesions in naturally coinfected sheep
title_full_unstemmed Detection of PrPSc in lung and mammary gland is favored by the presence of Visna/maedi virus lesions in naturally coinfected sheep
title_sort Detection of PrPSc in lung and mammary gland is favored by the presence of Visna/maedi virus lesions in naturally coinfected sheep
dc.creator.none.fl_str_mv Salazar, Eider
Monleón, Eva
Bolea, Rosa
Acín, Cristina
Pérez, Marta María
Álvarez, Neila
Leginagoikoa, Iratxe
Juste, Ramón
Minguijón, Esmeralda
Reina Arias, Ramsés
Glaría Ezquer, Idoia
Berriatua, Eduardo
Andrés Cara, Damián de
Badiola, Juan José
Amorena Zabalza, Beatriz
Luján, Lluís
author Salazar, Eider
author_facet Salazar, Eider
Monleón, Eva
Bolea, Rosa
Acín, Cristina
Pérez, Marta María
Álvarez, Neila
Leginagoikoa, Iratxe
Juste, Ramón
Minguijón, Esmeralda
Reina Arias, Ramsés
Glaría Ezquer, Idoia
Berriatua, Eduardo
Andrés Cara, Damián de
Badiola, Juan José
Amorena Zabalza, Beatriz
Luján, Lluís
author_role author
author2 Monleón, Eva
Bolea, Rosa
Acín, Cristina
Pérez, Marta María
Álvarez, Neila
Leginagoikoa, Iratxe
Juste, Ramón
Minguijón, Esmeralda
Reina Arias, Ramsés
Glaría Ezquer, Idoia
Berriatua, Eduardo
Andrés Cara, Damián de
Badiola, Juan José
Amorena Zabalza, Beatriz
Luján, Lluís
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv IdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutua
dc.subject.none.fl_str_mv Visna/maedi
Scrapie
Sheep
Coinfection
topic Visna/maedi
Scrapie
Sheep
Coinfection
description There are few reports on the pathogenesis of scrapie (Sc) and Visna/maedi virus (VMV) coinfections. The aim of this work was to study in vivo as well as post mortem both diseases in 91 sheep. Diagnosis of Sc and VMV infections allowed the distribution of animals into five groups according to the presence (+) or absence ( ) of infection by Sc and VMV: Sc /VMV , Sc /VMV+, Sc+/VMV and Sc+/ VMV+. The latter was divided into two subgroups, with and without VMV-induced lymphoid follicle hyperplasia (LFH), respectively. In both the lung and mammary gland, PrPSc deposits were found in the germinal center of hyperplasic lymphoid follicles in the subgroup of Sc+/VMV+ having VMV-induced LFH. This detection was always associated with (and likely preceded by) PrPSc observation in the corresponding lymph nodes. No PrPSc was found in other VMV-associated lesions. Animals suffering from scrapie had a statistically significantly lower mean age than the scrapie free animals at the time of death, with no apparent VMV influence. ARQ/ARQ genotype was the most abundant among the 91 ewes and the most frequent in scrapie-affected sheep. VMV infection does not seem to influence the scrapie risk group distribution among animals from the five groups established in this work. Altogether, these data indicate that certain VMVinduced lesions can favor PrPSc deposits in Sc non-target organs such as the lung and the mammary gland, making this coinfection an interesting field that warrants further research for a better comprehension of the pathogenesis of both diseases.
publishDate 2010
dc.date.none.fl_str_mv 2010
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/31529
url https://hdl.handle.net/2454/31529
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by-nc/3.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/3.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv EDP Sciences
publisher.none.fl_str_mv EDP Sciences
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname:Universidad Pública de Navarra
instname_str Universidad Pública de Navarra
reponame_str Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
collection Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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