Inhibin B and antiMüllerian hormone as surrogate markers of fertility in male and female Crohn's disease patients: a case-control study.

BACKGROUND: Several studies suggest that women with Crohn disease (CD) have reduced fertility due to decreased ovarian reserve, among other causes. On the other hand, male CD patients could have difficulties conceiving. The present study aimed to test the effect of CD on both male and female fertili...

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Autores: Gutiérrez A, Muñoz-Pérez R, Zapater P, Mira C, Rodríguez A, Sempere-Robles L, Torregrosa ME, Alfayate R, Moreno-Torres V, Bernal L, Belén-Galipienso O, Cameo JI, Sirera P, Herreros B, Bernabeu P, Moreno-Pérez O, Madero-Velázquez L
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p10416
Acceso en línea:https://isabial.portalinvestigacion.com/publicaciones10416
https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1374603/full
Access Level:acceso abierto
Palabra clave:Crohn’s disease
Sertoli cell
antiMüllerian hormone
fertility
follicle stimulating hormone (FSH)
inhibin-B
ovarian reserve
sexual dysfunction
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spelling Inhibin B and antiMüllerian hormone as surrogate markers of fertility in male and female Crohn's disease patients: a case-control study.Gutiérrez AMuñoz-Pérez RZapater PMira CRodríguez ASempere-Robles LTorregrosa MEAlfayate RMoreno-Torres VBernal LBelén-Galipienso OCameo JISirera PHerreros BBernabeu PMoreno-Pérez OMadero-Velázquez LCrohn’s diseaseSertoli cellantiMüllerian hormonefertilityfollicle stimulating hormone (FSH)inhibin-Bovarian reservesexual dysfunctionBACKGROUND: Several studies suggest that women with Crohn disease (CD) have reduced fertility due to decreased ovarian reserve, among other causes. On the other hand, male CD patients could have difficulties conceiving. The present study aimed to test the effect of CD on both male and female fertility potential, Sertoli cell function and ovarian reserve, assessed by inhibin-B (IB) plus IB:FSH ratio (IFR) and antiMüllerian hormone (AMH), respectively. Sexual dysfunction (SD) was studied as secondary endpoint. METHODS: We performed a cross-sectional, case-control study. Serum IB levels plus IFR were measured in 58 men with CD and compared to 25 age-matched healthy controls (HC). Serum AMH levels were measured in 50 women with CD and in 30 HC matched by age. SD was assessed by means of the International Index of Erectile Function (IIFE-15) in males and the Index of Female Sexual Function (IFSF) in women. RESULTS: A total of 108 CD patients and 55 HC were included. IB serum levels were significantly lower in CD men than in HC (177 ± 58 vs. 234 ± 75 pg./mL, p = 0.001). IFR was also decreased in CD patients compared to HC (58.27 ± 59.5 vs. 91.35 ± 60.04, p = 0.014). Women with CD > 30 years had lower serum AMH levels compared to HC (1.15 ± 0.74 vs. 2.14 ± 1.68 ng/mL, p = 0.033). In addition, CD women >30 years presented a serum AMH < 2 ng/mL more frequently than HC (90% vs. 40%, p = 0.004). The prevalence of SD was significantly higher among both male and female CD patients compared to HC, without association to fertility potential. Age was the only predictor of low ovarian reserve. CONCLUSION: Testicular Sertoli cell function assessed through serum IB levels and IFR is decreased in CD male patients compared to HC, regardless of age. Age > 30 years is the single independent predictor of reduced ovarian reserve in women with CD. These results should be confirmed in further studies in order to properly counsel patients with CD and desire for offspring.FRONTIERS MEDIA SA2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones10416https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1374603/fullFrontiers in MedicineISSN: 2296858Xreponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Inglésinfo:eu-repo/semantics/openAccessoai:isabial.fundanetsuite.com:p104162026-06-12T10:20:37Z
dc.title.none.fl_str_mv Inhibin B and antiMüllerian hormone as surrogate markers of fertility in male and female Crohn's disease patients: a case-control study.
title Inhibin B and antiMüllerian hormone as surrogate markers of fertility in male and female Crohn's disease patients: a case-control study.
spellingShingle Inhibin B and antiMüllerian hormone as surrogate markers of fertility in male and female Crohn's disease patients: a case-control study.
Gutiérrez A
Crohn’s disease
Sertoli cell
antiMüllerian hormone
fertility
follicle stimulating hormone (FSH)
inhibin-B
ovarian reserve
sexual dysfunction
title_short Inhibin B and antiMüllerian hormone as surrogate markers of fertility in male and female Crohn's disease patients: a case-control study.
title_full Inhibin B and antiMüllerian hormone as surrogate markers of fertility in male and female Crohn's disease patients: a case-control study.
title_fullStr Inhibin B and antiMüllerian hormone as surrogate markers of fertility in male and female Crohn's disease patients: a case-control study.
title_full_unstemmed Inhibin B and antiMüllerian hormone as surrogate markers of fertility in male and female Crohn's disease patients: a case-control study.
title_sort Inhibin B and antiMüllerian hormone as surrogate markers of fertility in male and female Crohn's disease patients: a case-control study.
dc.creator.none.fl_str_mv Gutiérrez A
Muñoz-Pérez R
Zapater P
Mira C
Rodríguez A
Sempere-Robles L
Torregrosa ME
Alfayate R
Moreno-Torres V
Bernal L
Belén-Galipienso O
Cameo JI
Sirera P
Herreros B
Bernabeu P
Moreno-Pérez O
Madero-Velázquez L
author Gutiérrez A
author_facet Gutiérrez A
Muñoz-Pérez R
Zapater P
Mira C
Rodríguez A
Sempere-Robles L
Torregrosa ME
Alfayate R
Moreno-Torres V
Bernal L
Belén-Galipienso O
Cameo JI
Sirera P
Herreros B
Bernabeu P
Moreno-Pérez O
Madero-Velázquez L
author_role author
author2 Muñoz-Pérez R
Zapater P
Mira C
Rodríguez A
Sempere-Robles L
Torregrosa ME
Alfayate R
Moreno-Torres V
Bernal L
Belén-Galipienso O
Cameo JI
Sirera P
Herreros B
Bernabeu P
Moreno-Pérez O
Madero-Velázquez L
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Crohn’s disease
Sertoli cell
antiMüllerian hormone
fertility
follicle stimulating hormone (FSH)
inhibin-B
ovarian reserve
sexual dysfunction
topic Crohn’s disease
Sertoli cell
antiMüllerian hormone
fertility
follicle stimulating hormone (FSH)
inhibin-B
ovarian reserve
sexual dysfunction
description BACKGROUND: Several studies suggest that women with Crohn disease (CD) have reduced fertility due to decreased ovarian reserve, among other causes. On the other hand, male CD patients could have difficulties conceiving. The present study aimed to test the effect of CD on both male and female fertility potential, Sertoli cell function and ovarian reserve, assessed by inhibin-B (IB) plus IB:FSH ratio (IFR) and antiMüllerian hormone (AMH), respectively. Sexual dysfunction (SD) was studied as secondary endpoint. METHODS: We performed a cross-sectional, case-control study. Serum IB levels plus IFR were measured in 58 men with CD and compared to 25 age-matched healthy controls (HC). Serum AMH levels were measured in 50 women with CD and in 30 HC matched by age. SD was assessed by means of the International Index of Erectile Function (IIFE-15) in males and the Index of Female Sexual Function (IFSF) in women. RESULTS: A total of 108 CD patients and 55 HC were included. IB serum levels were significantly lower in CD men than in HC (177 ± 58 vs. 234 ± 75 pg./mL, p = 0.001). IFR was also decreased in CD patients compared to HC (58.27 ± 59.5 vs. 91.35 ± 60.04, p = 0.014). Women with CD > 30 years had lower serum AMH levels compared to HC (1.15 ± 0.74 vs. 2.14 ± 1.68 ng/mL, p = 0.033). In addition, CD women >30 years presented a serum AMH < 2 ng/mL more frequently than HC (90% vs. 40%, p = 0.004). The prevalence of SD was significantly higher among both male and female CD patients compared to HC, without association to fertility potential. Age was the only predictor of low ovarian reserve. CONCLUSION: Testicular Sertoli cell function assessed through serum IB levels and IFR is decreased in CD male patients compared to HC, regardless of age. Age > 30 years is the single independent predictor of reduced ovarian reserve in women with CD. These results should be confirmed in further studies in order to properly counsel patients with CD and desire for offspring.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://isabial.portalinvestigacion.com/publicaciones10416
https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1374603/full
url https://isabial.portalinvestigacion.com/publicaciones10416
https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1374603/full
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv FRONTIERS MEDIA SA
publisher.none.fl_str_mv FRONTIERS MEDIA SA
dc.source.none.fl_str_mv Frontiers in Medicine
ISSN: 2296858X
reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
instname_str Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
reponame_str r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
collection r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
repository.name.fl_str_mv
repository.mail.fl_str_mv
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