The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine

Microseminoprotein-beta (MSMB) regulates apoptosis and using genome-wide association studies the rs10993994 single nucleotide polymorphism in the MSMB promoter has been linked to an increased risk of developing prostate cancer. The promoter location of the risk allele, and its ability to reduce prom...

ver descrição completa

Detalhes bibliográficos
Autores: Whitaker, Hayley C., Kote-Jarai, Zsofia, Ross-Adams, Helen, Warren, Anne Y., Burge, Johanna, George, Anne, Bancroft, Elizabeth K., Jhavar, Sameer, Leongamornlert, Daniel, Tymrakiewicz, Malgorzata, Saunders, Edward J., Page, Elizabeth, Mitra, Anita, Mitchell, Gillian, Lindeman, Geoffrey J., Evans, D. Gareth, Blanco Guillermo, Ignacio, Mercer, Catherine, Rubinstein, Wendy S., Neal, David E.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2010
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/44444
Acesso em linha:https://hdl.handle.net/2445/44444
Access Level:acceso abierto
Palavra-chave:Càncer de pròstata
Oncogens
Marcadors genètics
Prostate cancer
Oncogenes
Genetic markers
Descrição
Resumo:Microseminoprotein-beta (MSMB) regulates apoptosis and using genome-wide association studies the rs10993994 single nucleotide polymorphism in the MSMB promoter has been linked to an increased risk of developing prostate cancer. The promoter location of the risk allele, and its ability to reduce promoter activity, suggested that the rs10993994 risk allele could result in lowered MSMB in benign tissue leading to increased prostate cancer risk.

Registos relacionados