Sex differences in the prevalence of high-risk oral and anal human papillomavirus infections among heterosexually active populations in Ibadan, Nigeria

Purpose To determine sex differences in the prevalence of oral and anal high-risk HPV infections among heterosexually active males and females in Ibadan. Methods This was a secondary analysis from the Sexual Behavior and HPV Infections in Nigerians in Ibadan (SHINI) study that involved sexually acti...

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Autores: Morhason Bello, Imran O., Bello, Yusuf, Oke, Deborah, Daniel, Adekunle, Adisa, Akinyele, Fowotade, Adeola, Zheng, Yinan, Akinyemi, Joshua, Adewole, Isaac F., Pavón, Miquel Ángel, Murphy, Robert Leo, Hou, Lifang, Francis, Suzanna C., Watson Jones, Deborah
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/223350
Acceso en línea:https://hdl.handle.net/2445/223350
http://hdl.handle.net/2445/223350
Access Level:acceso abierto
Palabra clave:Papil·lomavirus
Malalties de transmissió sexual
Papillomaviruses
Sexually transmitted diseases
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spelling Sex differences in the prevalence of high-risk oral and anal human papillomavirus infections among heterosexually active populations in Ibadan, NigeriaMorhason Bello, Imran O.Bello, YusufOke, DeborahDaniel, AdekunleAdisa, AkinyeleFowotade, AdeolaZheng, YinanAkinyemi, JoshuaAdewole, Isaac F.Pavón, Miquel ÁngelMurphy, Robert LeoHou, LifangFrancis, Suzanna C.Watson Jones, DeborahPapil·lomavirusMalalties de transmissió sexualPapillomavirusesSexually transmitted diseasesPurpose To determine sex differences in the prevalence of oral and anal high-risk HPV infections among heterosexually active males and females in Ibadan. Methods This was a secondary analysis from the Sexual Behavior and HPV Infections in Nigerians in Ibadan (SHINI) study that involved sexually active males and females aged 18-45 years. After a face-to-face interview, samples were collected from the mouth, cervix, vulva, and anus by a sex-matched trained nurse. High-risk HPV (hrHPV) in oral or/and anal sites were primary outcome variables, profiled by AnyplexTM II HPV28 assay. The participants' demographic characteristics, sexual behaviors, and social lifestyle were included as explanatory variables. The chi-square or Fisher exact test was used to investigate the association between the presence of hrHPV and the participants' characteristics. Multivariable logistic regression was conducted to test the association between the sex of participants and each of the primary outcome after adjusting for potential confounders. Statistical significance was set at p < 0.05. Results A total of 625 females including 310 females in general population (FGP) and 315 female sex workers (FSWs) and 316 males were recruited. Oral hrHPV prevalence was higher among FGP and FSWs than among males (10.5% vs. 14.9% vs. 3.6%, p < 0.001), as was anal hrHPV prevalence (39.3% vs. 60.8% vs. 6.7%, p < 0.001). More FGP (7.5%) and FSWs (13.0%) than males (0.9%) had hrHPV at both oral and anal sites (p < 0.001). Males had significantly lower odds of oral hrHPV [adjusted odds ratio (aOR) = 0.43, 95% CI: 0.15-1.24] than FSWs and FGP [aOR = 1.70, 95% CI: 0.62-4.63]. The odds of anal hrHPV was significantly lower among males [aOR = 0.05, 95% CI: 0.03-0.08] compared to FSWs and FGP [aOR = 0.42, 95% CI: 0.30-0.58] Conclusion Oral hrHPV, anal hrHPV, and hrHPV at both sites were more prevalent in females than in males in the heterosexually active population. These findings highlight the importance of developing targeted HPV prevention strategies that account for sex-specific risk factors and the potential biological underpinnings contributing to these disparities.Frontiers Media SA2025202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion14 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/223350http://hdl.handle.net/2445/223350Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3389/frph.2025.1570984Frontiers in Reproductive Health, 2025, vol. 7https://doi.org/10.3389/frph.2025.1570984cc-by (c) Morhason Bello, Imran O. et al., 2025http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2233502026-05-29T05:05:01Z
dc.title.none.fl_str_mv Sex differences in the prevalence of high-risk oral and anal human papillomavirus infections among heterosexually active populations in Ibadan, Nigeria
title Sex differences in the prevalence of high-risk oral and anal human papillomavirus infections among heterosexually active populations in Ibadan, Nigeria
spellingShingle Sex differences in the prevalence of high-risk oral and anal human papillomavirus infections among heterosexually active populations in Ibadan, Nigeria
Morhason Bello, Imran O.
Papil·lomavirus
Malalties de transmissió sexual
Papillomaviruses
Sexually transmitted diseases
title_short Sex differences in the prevalence of high-risk oral and anal human papillomavirus infections among heterosexually active populations in Ibadan, Nigeria
title_full Sex differences in the prevalence of high-risk oral and anal human papillomavirus infections among heterosexually active populations in Ibadan, Nigeria
title_fullStr Sex differences in the prevalence of high-risk oral and anal human papillomavirus infections among heterosexually active populations in Ibadan, Nigeria
title_full_unstemmed Sex differences in the prevalence of high-risk oral and anal human papillomavirus infections among heterosexually active populations in Ibadan, Nigeria
title_sort Sex differences in the prevalence of high-risk oral and anal human papillomavirus infections among heterosexually active populations in Ibadan, Nigeria
dc.creator.none.fl_str_mv Morhason Bello, Imran O.
Bello, Yusuf
Oke, Deborah
Daniel, Adekunle
Adisa, Akinyele
Fowotade, Adeola
Zheng, Yinan
Akinyemi, Joshua
Adewole, Isaac F.
Pavón, Miquel Ángel
Murphy, Robert Leo
Hou, Lifang
Francis, Suzanna C.
Watson Jones, Deborah
author Morhason Bello, Imran O.
author_facet Morhason Bello, Imran O.
Bello, Yusuf
Oke, Deborah
Daniel, Adekunle
Adisa, Akinyele
Fowotade, Adeola
Zheng, Yinan
Akinyemi, Joshua
Adewole, Isaac F.
Pavón, Miquel Ángel
Murphy, Robert Leo
Hou, Lifang
Francis, Suzanna C.
Watson Jones, Deborah
author_role author
author2 Bello, Yusuf
Oke, Deborah
Daniel, Adekunle
Adisa, Akinyele
Fowotade, Adeola
Zheng, Yinan
Akinyemi, Joshua
Adewole, Isaac F.
Pavón, Miquel Ángel
Murphy, Robert Leo
Hou, Lifang
Francis, Suzanna C.
Watson Jones, Deborah
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Papil·lomavirus
Malalties de transmissió sexual
Papillomaviruses
Sexually transmitted diseases
topic Papil·lomavirus
Malalties de transmissió sexual
Papillomaviruses
Sexually transmitted diseases
description Purpose To determine sex differences in the prevalence of oral and anal high-risk HPV infections among heterosexually active males and females in Ibadan. Methods This was a secondary analysis from the Sexual Behavior and HPV Infections in Nigerians in Ibadan (SHINI) study that involved sexually active males and females aged 18-45 years. After a face-to-face interview, samples were collected from the mouth, cervix, vulva, and anus by a sex-matched trained nurse. High-risk HPV (hrHPV) in oral or/and anal sites were primary outcome variables, profiled by AnyplexTM II HPV28 assay. The participants' demographic characteristics, sexual behaviors, and social lifestyle were included as explanatory variables. The chi-square or Fisher exact test was used to investigate the association between the presence of hrHPV and the participants' characteristics. Multivariable logistic regression was conducted to test the association between the sex of participants and each of the primary outcome after adjusting for potential confounders. Statistical significance was set at p < 0.05. Results A total of 625 females including 310 females in general population (FGP) and 315 female sex workers (FSWs) and 316 males were recruited. Oral hrHPV prevalence was higher among FGP and FSWs than among males (10.5% vs. 14.9% vs. 3.6%, p < 0.001), as was anal hrHPV prevalence (39.3% vs. 60.8% vs. 6.7%, p < 0.001). More FGP (7.5%) and FSWs (13.0%) than males (0.9%) had hrHPV at both oral and anal sites (p < 0.001). Males had significantly lower odds of oral hrHPV [adjusted odds ratio (aOR) = 0.43, 95% CI: 0.15-1.24] than FSWs and FGP [aOR = 1.70, 95% CI: 0.62-4.63]. The odds of anal hrHPV was significantly lower among males [aOR = 0.05, 95% CI: 0.03-0.08] compared to FSWs and FGP [aOR = 0.42, 95% CI: 0.30-0.58] Conclusion Oral hrHPV, anal hrHPV, and hrHPV at both sites were more prevalent in females than in males in the heterosexually active population. These findings highlight the importance of developing targeted HPV prevention strategies that account for sex-specific risk factors and the potential biological underpinnings contributing to these disparities.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/223350
http://hdl.handle.net/2445/223350
url https://hdl.handle.net/2445/223350
http://hdl.handle.net/2445/223350
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/frph.2025.1570984
Frontiers in Reproductive Health, 2025, vol. 7
https://doi.org/10.3389/frph.2025.1570984
dc.rights.none.fl_str_mv cc-by (c) Morhason Bello, Imran O. et al., 2025
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Morhason Bello, Imran O. et al., 2025
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media SA
publisher.none.fl_str_mv Frontiers Media SA
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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