Guanine and pregnenolone sulfate are associated with incident type 2 diabetes in two independent populations.

BACKGROUND: Type 2 diabetes (T2D) is increasing its burden worldwide; therefore, research focused on its prediction and prevention is essential. METHODS: We performed an untargeted metabolomics analysis using ultra high-performance liquid chromatography-mass spectrometry to discover metabolic biomar...

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Autores: Barranco, M., Granado, Minerva, Yanes, Oscar, Capellades, Jordi, Junza, Alexandra, Franch, Josep, Vendrell, Joan, Llauradó, Gemma, Valdés, Sergio, García, Eva, Bermúdez, Marcelino, Valdivieso, José Manuel, López, Víctor Miguel, Herrero, Celia, Falguera, Mireia, Vilanova, María Belén, Arteaga, Ingrid, Torán, Pere, Perera, A., Castelblanco, Esmeralda, Mauricio, Dídac
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p29747
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=29747
Access Level:acceso abierto
Palabra clave:incident type 2 diabetes
liquid chromatography
mass spectrometry
targeted metabolomics
untargeted metabolomics
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spelling Guanine and pregnenolone sulfate are associated with incident type 2 diabetes in two independent populations.Barranco, M.Granado, MinervaYanes, OscarCapellades, JordiJunza, AlexandraFranch, JosepVendrell, JoanLlauradó, GemmaValdés, SergioGarcía, EvaBermúdez, MarcelinoValdivieso, José ManuelLópez, Víctor MiguelHerrero, CeliaFalguera, MireiaVilanova, María BelénArteaga, IngridTorán, PerePerera, A.Castelblanco, EsmeraldaMauricio, Dídacincident type 2 diabetesliquid chromatographymass spectrometrytargeted metabolomicsuntargeted metabolomicsBACKGROUND: Type 2 diabetes (T2D) is increasing its burden worldwide; therefore, research focused on its prediction and prevention is essential. METHODS: We performed an untargeted metabolomics analysis using ultra high-performance liquid chromatography-mass spectrometry to discover metabolic biomarkers and biological pathways associated with incident T2D with a nested case-control design, followed by validation with targeted metabolomics in an independent cohort. In the discovery phase, plasma samples from 352 subjects (209 controls and 143 incident cases) were analyzed, collected with a mean (standard deviation) of 7.40 (0.76) years before they acquired the condition. Using this discovery phase cohort, six metabolites were identified using standards and were subsequently quantified in an independent validation phase cohort of 2,044 subjects (167 incident cases). Additionally, pathway enrichment was conducted in the discovery cohort. RESULTS: Guanine, ecgonine, adenine, pregnenolone sulfate, phenyl sulfate, and citrulline were significantly associated with incident T2D in at least one of the analyses performed in the discovery phase. Among these, guanine, pregnenolone sulfate, and citrulline maintained their significant associations with incident T2D in the validation cohort. Additionally, several pathways were significantly altered, with nucleotide metabolism and ABC transporter pathways among the most consistently affected. CONCLUSION: We identified significant associations of guanine, pregnenolone sulfate, and citrulline with incident T2D.FRONTIERS MEDIA SA2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=29747Frontiers in EndocrinologyISSN: 16642392reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p297472026-05-27T12:37:41Z
dc.title.none.fl_str_mv Guanine and pregnenolone sulfate are associated with incident type 2 diabetes in two independent populations.
title Guanine and pregnenolone sulfate are associated with incident type 2 diabetes in two independent populations.
spellingShingle Guanine and pregnenolone sulfate are associated with incident type 2 diabetes in two independent populations.
Barranco, M.
incident type 2 diabetes
liquid chromatography
mass spectrometry
targeted metabolomics
untargeted metabolomics
title_short Guanine and pregnenolone sulfate are associated with incident type 2 diabetes in two independent populations.
title_full Guanine and pregnenolone sulfate are associated with incident type 2 diabetes in two independent populations.
title_fullStr Guanine and pregnenolone sulfate are associated with incident type 2 diabetes in two independent populations.
title_full_unstemmed Guanine and pregnenolone sulfate are associated with incident type 2 diabetes in two independent populations.
title_sort Guanine and pregnenolone sulfate are associated with incident type 2 diabetes in two independent populations.
dc.creator.none.fl_str_mv Barranco, M.
Granado, Minerva
Yanes, Oscar
Capellades, Jordi
Junza, Alexandra
Franch, Josep
Vendrell, Joan
Llauradó, Gemma
Valdés, Sergio
García, Eva
Bermúdez, Marcelino
Valdivieso, José Manuel
López, Víctor Miguel
Herrero, Celia
Falguera, Mireia
Vilanova, María Belén
Arteaga, Ingrid
Torán, Pere
Perera, A.
Castelblanco, Esmeralda
Mauricio, Dídac
author Barranco, M.
author_facet Barranco, M.
Granado, Minerva
Yanes, Oscar
Capellades, Jordi
Junza, Alexandra
Franch, Josep
Vendrell, Joan
Llauradó, Gemma
Valdés, Sergio
García, Eva
Bermúdez, Marcelino
Valdivieso, José Manuel
López, Víctor Miguel
Herrero, Celia
Falguera, Mireia
Vilanova, María Belén
Arteaga, Ingrid
Torán, Pere
Perera, A.
Castelblanco, Esmeralda
Mauricio, Dídac
author_role author
author2 Granado, Minerva
Yanes, Oscar
Capellades, Jordi
Junza, Alexandra
Franch, Josep
Vendrell, Joan
Llauradó, Gemma
Valdés, Sergio
García, Eva
Bermúdez, Marcelino
Valdivieso, José Manuel
López, Víctor Miguel
Herrero, Celia
Falguera, Mireia
Vilanova, María Belén
Arteaga, Ingrid
Torán, Pere
Perera, A.
Castelblanco, Esmeralda
Mauricio, Dídac
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv incident type 2 diabetes
liquid chromatography
mass spectrometry
targeted metabolomics
untargeted metabolomics
topic incident type 2 diabetes
liquid chromatography
mass spectrometry
targeted metabolomics
untargeted metabolomics
description BACKGROUND: Type 2 diabetes (T2D) is increasing its burden worldwide; therefore, research focused on its prediction and prevention is essential. METHODS: We performed an untargeted metabolomics analysis using ultra high-performance liquid chromatography-mass spectrometry to discover metabolic biomarkers and biological pathways associated with incident T2D with a nested case-control design, followed by validation with targeted metabolomics in an independent cohort. In the discovery phase, plasma samples from 352 subjects (209 controls and 143 incident cases) were analyzed, collected with a mean (standard deviation) of 7.40 (0.76) years before they acquired the condition. Using this discovery phase cohort, six metabolites were identified using standards and were subsequently quantified in an independent validation phase cohort of 2,044 subjects (167 incident cases). Additionally, pathway enrichment was conducted in the discovery cohort. RESULTS: Guanine, ecgonine, adenine, pregnenolone sulfate, phenyl sulfate, and citrulline were significantly associated with incident T2D in at least one of the analyses performed in the discovery phase. Among these, guanine, pregnenolone sulfate, and citrulline maintained their significant associations with incident T2D in the validation cohort. Additionally, several pathways were significantly altered, with nucleotide metabolism and ABC transporter pathways among the most consistently affected. CONCLUSION: We identified significant associations of guanine, pregnenolone sulfate, and citrulline with incident T2D.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=29747
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=29747
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv FRONTIERS MEDIA SA
publisher.none.fl_str_mv FRONTIERS MEDIA SA
dc.source.none.fl_str_mv Frontiers in Endocrinology
ISSN: 16642392
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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