Association of hyperuricemia and gamma glutamyl transferase as a marker of metabolic risk in alcohol use disorder

Excessive alcohol consumption leads to overproduction of urates and renal function plays a critical role in serum uric acid levels. We aimed to assess associations of hyperuricemia in patients with alcohol use disorder (AUD) and comparable Glomerular Filtration Rate (GFR). A total of 686 patients un...

Descripción completa

Detalles Bibliográficos
Autores: Hernández Rubio, Anna, Sanvisens, Arantza, Bolao, Ferran, Pérez Mañá, Clara, García Marchena, Nuria, Fernández Prendes, Carla, Muñoz, Alvaro, Muga, Roberto
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/173784
Acceso en línea:https://hdl.handle.net/2445/173784
Access Level:acceso abierto
Palabra clave:Hiperuricèmia
Consum d'alcohol
Hyperuricemia
Drinking of alcoholic beverages
id ES_4792f4e9bfa50b67966c2ff0f607d9c8
oai_identifier_str oai:recercat.cat:2445/173784
network_acronym_str ES
network_name_str España
repository_id_str
spelling Association of hyperuricemia and gamma glutamyl transferase as a marker of metabolic risk in alcohol use disorderHernández Rubio, AnnaSanvisens, ArantzaBolao, FerranPérez Mañá, ClaraGarcía Marchena, NuriaFernández Prendes, CarlaMuñoz, AlvaroMuga, RobertoHiperuricèmiaConsum d'alcoholHyperuricemiaDrinking of alcoholic beveragesExcessive alcohol consumption leads to overproduction of urates and renal function plays a critical role in serum uric acid levels. We aimed to assess associations of hyperuricemia in patients with alcohol use disorder (AUD) and comparable Glomerular Filtration Rate (GFR). A total of 686 patients undergoing treatment for AUD between 2013 and 2017 were eligible (77% men); age at admission was 47 years [interquartile range (IQR), 40-53 years], age of onset of alcohol consumption was 16 years [IQR, 16-18 years] and the amount of alcohol consumed was 160 g/day [IQR, 120-240 g/day]. Body Mass Index was 24.7 kg/m(2) [IQR, 21.9-28.4 kg/m(2)], eGFR was 105 mL/min/1.73 m(2) [IQR, 95.7-113.0 mL], 9.7% had metabolic syndrome and 23% had advanced liver fibrosis (FIB-4>3.25). Prevalence of hyperuricemia was 12.5%. The eGFR-adjusted multivariate analysis showed that relative to patients with GGT <= 50, those with GGT between 51 and 300 U/L and those with GGT>300 U/L were 4.31 (95% CI 1.62-11.46) and 10.3 (95% CI 3.50-29.90) times more likely to have hyperuricemia, respectively. Our data shows that hyperuricemia in the context of AUD is strongly associated with serum GGT levels and suggest an increased cardio-metabolic risk in this population.Nature Research2021202120202021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion8 p.application/pdfhttps://hdl.handle.net/2445/173784Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1038/s41598-020-77013-1Scientific Reports, 2020, vol. 10https://doi.org/10.1038/s41598-020-77013-1cc by (c) Hernández Rubio et al., 2020http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1737842026-05-29T05:05:01Z
dc.title.none.fl_str_mv Association of hyperuricemia and gamma glutamyl transferase as a marker of metabolic risk in alcohol use disorder
title Association of hyperuricemia and gamma glutamyl transferase as a marker of metabolic risk in alcohol use disorder
spellingShingle Association of hyperuricemia and gamma glutamyl transferase as a marker of metabolic risk in alcohol use disorder
Hernández Rubio, Anna
Hiperuricèmia
Consum d'alcohol
Hyperuricemia
Drinking of alcoholic beverages
title_short Association of hyperuricemia and gamma glutamyl transferase as a marker of metabolic risk in alcohol use disorder
title_full Association of hyperuricemia and gamma glutamyl transferase as a marker of metabolic risk in alcohol use disorder
title_fullStr Association of hyperuricemia and gamma glutamyl transferase as a marker of metabolic risk in alcohol use disorder
title_full_unstemmed Association of hyperuricemia and gamma glutamyl transferase as a marker of metabolic risk in alcohol use disorder
title_sort Association of hyperuricemia and gamma glutamyl transferase as a marker of metabolic risk in alcohol use disorder
dc.creator.none.fl_str_mv Hernández Rubio, Anna
Sanvisens, Arantza
Bolao, Ferran
Pérez Mañá, Clara
García Marchena, Nuria
Fernández Prendes, Carla
Muñoz, Alvaro
Muga, Roberto
author Hernández Rubio, Anna
author_facet Hernández Rubio, Anna
Sanvisens, Arantza
Bolao, Ferran
Pérez Mañá, Clara
García Marchena, Nuria
Fernández Prendes, Carla
Muñoz, Alvaro
Muga, Roberto
author_role author
author2 Sanvisens, Arantza
Bolao, Ferran
Pérez Mañá, Clara
García Marchena, Nuria
Fernández Prendes, Carla
Muñoz, Alvaro
Muga, Roberto
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Hiperuricèmia
Consum d'alcohol
Hyperuricemia
Drinking of alcoholic beverages
topic Hiperuricèmia
Consum d'alcohol
Hyperuricemia
Drinking of alcoholic beverages
description Excessive alcohol consumption leads to overproduction of urates and renal function plays a critical role in serum uric acid levels. We aimed to assess associations of hyperuricemia in patients with alcohol use disorder (AUD) and comparable Glomerular Filtration Rate (GFR). A total of 686 patients undergoing treatment for AUD between 2013 and 2017 were eligible (77% men); age at admission was 47 years [interquartile range (IQR), 40-53 years], age of onset of alcohol consumption was 16 years [IQR, 16-18 years] and the amount of alcohol consumed was 160 g/day [IQR, 120-240 g/day]. Body Mass Index was 24.7 kg/m(2) [IQR, 21.9-28.4 kg/m(2)], eGFR was 105 mL/min/1.73 m(2) [IQR, 95.7-113.0 mL], 9.7% had metabolic syndrome and 23% had advanced liver fibrosis (FIB-4>3.25). Prevalence of hyperuricemia was 12.5%. The eGFR-adjusted multivariate analysis showed that relative to patients with GGT <= 50, those with GGT between 51 and 300 U/L and those with GGT>300 U/L were 4.31 (95% CI 1.62-11.46) and 10.3 (95% CI 3.50-29.90) times more likely to have hyperuricemia, respectively. Our data shows that hyperuricemia in the context of AUD is strongly associated with serum GGT levels and suggest an increased cardio-metabolic risk in this population.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/173784
url https://hdl.handle.net/2445/173784
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41598-020-77013-1
Scientific Reports, 2020, vol. 10
https://doi.org/10.1038/s41598-020-77013-1
dc.rights.none.fl_str_mv cc by (c) Hernández Rubio et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Hernández Rubio et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8 p.
application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869407303406452736
score 15,81155

Similares en LA Referencia