Metabolic pathways of the colonic metabolism of flavonoids (flavonols, flavones and flavanones) and phenolic acids

Flavonoids are metabolized by the gut microflora giving rise to a wide range of phenolic acids that may exert systemic effects in the body. Nevertheless, the colonic metabolism pathways and the function of the metabolites formed are poorly studied. In the present study, the individual colonic metabo...

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Autores: Serra Maqueda, Aida, Romero Fabregat, Mª Paz, Reguant, Jordi, Ortega Olivé, Nàdia, Motilva Casado, Mª José
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2011
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/469314
Acceso en línea:https://doi.org/10.1016/j.foodchem.2011.07.055
https://hdl.handle.net/10459.1/469314
Access Level:acceso abierto
Palabra clave:Colonic microflora fermentation
Digestion
Flavonoids
Metabolic pathway
Phenolic acids
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spelling Metabolic pathways of the colonic metabolism of flavonoids (flavonols, flavones and flavanones) and phenolic acidsSerra Maqueda, AidaRomero Fabregat, Mª PazReguant, JordiOrtega Olivé, NàdiaMotilva Casado, Mª JoséColonic microflora fermentationDigestionFlavonoidsMetabolic pathwayPhenolic acidsFlavonoids are metabolized by the gut microflora giving rise to a wide range of phenolic acids that may exert systemic effects in the body. Nevertheless, the colonic metabolism pathways and the function of the metabolites formed are poorly studied. In the present study, the individual colonic metabolism of three subclasses of flavonoids (flavonols, flavones and flavanones) and phenolic acids was evaluated. For this, seven standards of flavonoids (quercetin, quercetin–rhamnoside, quercetin–rutinoside, myricetin, luteolin, naringenin and kaempferol–rutinoside) and two phenolic acids (protocatechuic acid and gallic acid) were submitted to an in vitro fermentation model using rat colonic microflora. Simultaneously, a nuts–cocoa cream enriched with these standards of flavonoids was incubated and the colonic metabolism of these compounds was evaluated. The results showed that the greatest number of colonic metabolites came from the fermentation of quercetin and quercetin–rhamnoside, and the maximum concentration of fermentation products was observed after 48 h of fermentation. On the other hand, a smaller number of fermentation products were observed after the colonic fermentation of kaempferol–rutinoside, naringenin, luteolin and myricetin. The phenolic acids were slightly metabolized by the colonic microflora.The present study was supported by the CENIT program from the Spanish Minister of Industry and by a consortium of companies led by La Morella Nuts S.A. (Reus, Catalonia, Spain) with the following companies: Shirota Functional Foods, S.L.; KRAFT; BTSA, Biotecnologías Aplicadas, S.L.; Selección Batallé, S.A.; Industrial Técnica Pecuaria, S.A.; Neuron BioPharma, S.A.; Grupo Leche Pascual, S.A.U.; Innaves, S.A. The present work was also supported by the Catalan Government (Interdepartmental Commission for Research and Technological Innovation) with the A. Serra grant. We also thank the technical support of Carme Piñol, Jessica Pairada and Roser Pane from the Animal Facility Service of University of Lleida. We are grateful to Sergi Traver for his help with the development of the experimental.Elsevier2011info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttps://doi.org/10.1016/j.foodchem.2011.07.055https://hdl.handle.net/10459.1/469314reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésVersió postprint del document publicat a: https://doi.org/10.1016/j.foodchem.2011.07.055Food Chemistry, 2012, vol. 130, núm. 2, p. 383-393cc-by-nc-nd (c) Elsevier, 2011Attribution-NonCommercial-NoDerivatives 4.0 Internationalinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:repositori.udl.cat:10459.1/4693142026-06-24T12:42:17Z
dc.title.none.fl_str_mv Metabolic pathways of the colonic metabolism of flavonoids (flavonols, flavones and flavanones) and phenolic acids
title Metabolic pathways of the colonic metabolism of flavonoids (flavonols, flavones and flavanones) and phenolic acids
spellingShingle Metabolic pathways of the colonic metabolism of flavonoids (flavonols, flavones and flavanones) and phenolic acids
Serra Maqueda, Aida
Colonic microflora fermentation
Digestion
Flavonoids
Metabolic pathway
Phenolic acids
title_short Metabolic pathways of the colonic metabolism of flavonoids (flavonols, flavones and flavanones) and phenolic acids
title_full Metabolic pathways of the colonic metabolism of flavonoids (flavonols, flavones and flavanones) and phenolic acids
title_fullStr Metabolic pathways of the colonic metabolism of flavonoids (flavonols, flavones and flavanones) and phenolic acids
title_full_unstemmed Metabolic pathways of the colonic metabolism of flavonoids (flavonols, flavones and flavanones) and phenolic acids
title_sort Metabolic pathways of the colonic metabolism of flavonoids (flavonols, flavones and flavanones) and phenolic acids
dc.creator.none.fl_str_mv Serra Maqueda, Aida
Romero Fabregat, Mª Paz
Reguant, Jordi
Ortega Olivé, Nàdia
Motilva Casado, Mª José
author Serra Maqueda, Aida
author_facet Serra Maqueda, Aida
Romero Fabregat, Mª Paz
Reguant, Jordi
Ortega Olivé, Nàdia
Motilva Casado, Mª José
author_role author
author2 Romero Fabregat, Mª Paz
Reguant, Jordi
Ortega Olivé, Nàdia
Motilva Casado, Mª José
author2_role author
author
author
author
dc.subject.none.fl_str_mv Colonic microflora fermentation
Digestion
Flavonoids
Metabolic pathway
Phenolic acids
topic Colonic microflora fermentation
Digestion
Flavonoids
Metabolic pathway
Phenolic acids
description Flavonoids are metabolized by the gut microflora giving rise to a wide range of phenolic acids that may exert systemic effects in the body. Nevertheless, the colonic metabolism pathways and the function of the metabolites formed are poorly studied. In the present study, the individual colonic metabolism of three subclasses of flavonoids (flavonols, flavones and flavanones) and phenolic acids was evaluated. For this, seven standards of flavonoids (quercetin, quercetin–rhamnoside, quercetin–rutinoside, myricetin, luteolin, naringenin and kaempferol–rutinoside) and two phenolic acids (protocatechuic acid and gallic acid) were submitted to an in vitro fermentation model using rat colonic microflora. Simultaneously, a nuts–cocoa cream enriched with these standards of flavonoids was incubated and the colonic metabolism of these compounds was evaluated. The results showed that the greatest number of colonic metabolites came from the fermentation of quercetin and quercetin–rhamnoside, and the maximum concentration of fermentation products was observed after 48 h of fermentation. On the other hand, a smaller number of fermentation products were observed after the colonic fermentation of kaempferol–rutinoside, naringenin, luteolin and myricetin. The phenolic acids were slightly metabolized by the colonic microflora.
publishDate 2011
dc.date.none.fl_str_mv 2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1016/j.foodchem.2011.07.055
https://hdl.handle.net/10459.1/469314
url https://doi.org/10.1016/j.foodchem.2011.07.055
https://hdl.handle.net/10459.1/469314
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.foodchem.2011.07.055
Food Chemistry, 2012, vol. 130, núm. 2, p. 383-393
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Elsevier, 2011
Attribution-NonCommercial-NoDerivatives 4.0 International
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
rights_invalid_str_mv cc-by-nc-nd (c) Elsevier, 2011
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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