A phase I trial of oncolytic adenovirus ICOVIR-5 administered intravenously to cutaneous and uveal melanoma patients
Oncolytic viruses represent a unique type of agents that combine self-amplification, lytic, and immunostimulatory properties against tumors. A local and locoregional clinical benefit has been demonstrated upon intratumoral injections of an oncolytic herpes virus in melanoma patients, leading to its...
| Autores: | , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/128524 |
| Acceso en línea: | https://hdl.handle.net/2445/128524 |
| Access Level: | acceso abierto |
| Palabra clave: | Melanoma Virus oncogènics Herpes Oncogenic viruses Herpesvirus diseases |
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A phase I trial of oncolytic adenovirus ICOVIR-5 administered intravenously to cutaneous and uveal melanoma patientsGarcía Martin, MargaritaMoreno Olié, RafaelGil-Martín, MartaCascallò, ManelOchoa de Olza, MariaCuadra, CarmenPiulats, Josep M.Navarro-Pérez, ValentinDomenech, MartaAlemany Bonastre, RamonSalazar Soler, RamónMelanomaVirus oncogènicsHerpesOncogenic virusesHerpesvirus diseasesOncolytic viruses represent a unique type of agents that combine self-amplification, lytic, and immunostimulatory properties against tumors. A local and locoregional clinical benefit has been demonstrated upon intratumoral injections of an oncolytic herpes virus in melanoma patients, leading to its approval in the United States and Europe for patients without visceral disease (up to stage IVM1a). However, in order to debulk and change the local immunosuppressive environment of tumors that cannot be injected directly, oncolyitc viruses need to be administered systemically. Among different viruses, adenovirus has been extensively used in clinical trials but with few evidences of activity upon systemic administration. Preclinical efficacy of a single intravenous administration of our oncolytic adenovirus ICOVIR5, an adenovirus type 5 responsive to the retinoblastoma pathway commonly deregulated in tumors, led us to use this virus in a dose-escalation phase 1 trial in metastatic melanoma patients. The results in 12 patients treated with a single infusion of a dose up to 1 × 1013 viral particles show that ICOVIR5 can reach melanoma metastases upon a single intravenous administration but fails to induce tumor regressions. These results support the systemic administration of armed oncolytic viruses to treat disseminated cancer.Mary Ann Liebert, Inc.2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/128524Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: http://dx.doi.org/10.1089/hum.2018.107http://dx.doi.org/10.1089/hum.2018.107(c) Mary Ann Liebert, Inc., 2019info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1285242026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
A phase I trial of oncolytic adenovirus ICOVIR-5 administered intravenously to cutaneous and uveal melanoma patients |
| title |
A phase I trial of oncolytic adenovirus ICOVIR-5 administered intravenously to cutaneous and uveal melanoma patients |
| spellingShingle |
A phase I trial of oncolytic adenovirus ICOVIR-5 administered intravenously to cutaneous and uveal melanoma patients García Martin, Margarita Melanoma Virus oncogènics Herpes Oncogenic viruses Herpesvirus diseases |
| title_short |
A phase I trial of oncolytic adenovirus ICOVIR-5 administered intravenously to cutaneous and uveal melanoma patients |
| title_full |
A phase I trial of oncolytic adenovirus ICOVIR-5 administered intravenously to cutaneous and uveal melanoma patients |
| title_fullStr |
A phase I trial of oncolytic adenovirus ICOVIR-5 administered intravenously to cutaneous and uveal melanoma patients |
| title_full_unstemmed |
A phase I trial of oncolytic adenovirus ICOVIR-5 administered intravenously to cutaneous and uveal melanoma patients |
| title_sort |
A phase I trial of oncolytic adenovirus ICOVIR-5 administered intravenously to cutaneous and uveal melanoma patients |
| dc.creator.none.fl_str_mv |
García Martin, Margarita Moreno Olié, Rafael Gil-Martín, Marta Cascallò, Manel Ochoa de Olza, Maria Cuadra, Carmen Piulats, Josep M. Navarro-Pérez, Valentin Domenech, Marta Alemany Bonastre, Ramon Salazar Soler, Ramón |
| author |
García Martin, Margarita |
| author_facet |
García Martin, Margarita Moreno Olié, Rafael Gil-Martín, Marta Cascallò, Manel Ochoa de Olza, Maria Cuadra, Carmen Piulats, Josep M. Navarro-Pérez, Valentin Domenech, Marta Alemany Bonastre, Ramon Salazar Soler, Ramón |
| author_role |
author |
| author2 |
Moreno Olié, Rafael Gil-Martín, Marta Cascallò, Manel Ochoa de Olza, Maria Cuadra, Carmen Piulats, Josep M. Navarro-Pérez, Valentin Domenech, Marta Alemany Bonastre, Ramon Salazar Soler, Ramón |
| author2_role |
author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Melanoma Virus oncogènics Herpes Oncogenic viruses Herpesvirus diseases |
| topic |
Melanoma Virus oncogènics Herpes Oncogenic viruses Herpesvirus diseases |
| description |
Oncolytic viruses represent a unique type of agents that combine self-amplification, lytic, and immunostimulatory properties against tumors. A local and locoregional clinical benefit has been demonstrated upon intratumoral injections of an oncolytic herpes virus in melanoma patients, leading to its approval in the United States and Europe for patients without visceral disease (up to stage IVM1a). However, in order to debulk and change the local immunosuppressive environment of tumors that cannot be injected directly, oncolyitc viruses need to be administered systemically. Among different viruses, adenovirus has been extensively used in clinical trials but with few evidences of activity upon systemic administration. Preclinical efficacy of a single intravenous administration of our oncolytic adenovirus ICOVIR5, an adenovirus type 5 responsive to the retinoblastoma pathway commonly deregulated in tumors, led us to use this virus in a dose-escalation phase 1 trial in metastatic melanoma patients. The results in 12 patients treated with a single infusion of a dose up to 1 × 1013 viral particles show that ICOVIR5 can reach melanoma metastases upon a single intravenous administration but fails to induce tumor regressions. These results support the systemic administration of armed oncolytic viruses to treat disseminated cancer. |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion |
| format |
article |
| status_str |
acceptedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/128524 |
| url |
https://hdl.handle.net/2445/128524 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Versió postprint del document publicat a: http://dx.doi.org/10.1089/hum.2018.107 http://dx.doi.org/10.1089/hum.2018.107 |
| dc.rights.none.fl_str_mv |
(c) Mary Ann Liebert, Inc., 2019 info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
(c) Mary Ann Liebert, Inc., 2019 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Mary Ann Liebert, Inc. |
| publisher.none.fl_str_mv |
Mary Ann Liebert, Inc. |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
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Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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