Neural basis of acquired amusia and its recovery after stroke

Although acquired amusia is a relatively common disorder after stroke, its precise neuroanatomical basis is still unknown. To evaluate which brain regions form the neural substrate for acquired amusia and its recovery, we performed a voxel-based lesion-symptom mapping (VLSM) and morphometry (VBM) st...

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Autores: Sihvonen, Aleksi J., Ripollés, Pablo, Leo, Vera, Rodríguez Fornells, Antoni, Soinila, Seppo, Särkämö, Teppo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/109265
Acceso en línea:https://hdl.handle.net/2445/109265
Access Level:acceso abierto
Palabra clave:Mapatge del cervell
Lesions cerebrals
Afàsia
Brain mapping
Brain damage
Aphasia
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spelling Neural basis of acquired amusia and its recovery after strokeSihvonen, Aleksi J.Ripollés, PabloLeo, VeraRodríguez Fornells, AntoniSoinila, SeppoSärkämö, TeppoMapatge del cervellLesions cerebralsAfàsiaBrain mappingBrain damageAphasiaAlthough acquired amusia is a relatively common disorder after stroke, its precise neuroanatomical basis is still unknown. To evaluate which brain regions form the neural substrate for acquired amusia and its recovery, we performed a voxel-based lesion-symptom mapping (VLSM) and morphometry (VBM) study with 77 human stroke subjects. Structural MRIs were acquired at acute and 6 month poststroke stages. Amusia and aphasia were behaviorally assessed at acute and 3 month poststroke stages using the Scale and Rhythm subtests of the Montreal Battery of Evaluation of Amusia (MBEA) and language tests. VLSM analyses indicated that amusia was associated with a lesion area comprising the superior temporal gyrus, Heschl's gyrus, insula, and striatum in the right hemisphere, clearly different from the lesion pattern associated with aphasia. Parametric analyses of MBEA Pitch and Rhythm scores showed extensive lesion overlap in the right striatum, as well as in the right Heschl's gyrus and superior temporal gyrus. Lesions associated with Rhythm scores extended more superiorly and posterolaterally. VBM analysis of volume changes from the acute to the 6 month stage showed a clear decrease in gray matter volume in the right superior and middle temporal gyri in nonrecovered amusic patients compared with nonamusic patients. This increased atrophy was more evident in anterior temporal areas in rhythm amusia and in posterior temporal and temporoparietal areas in pitch amusia. Overall, the results implicate right temporal and subcortical regions as the crucial neural substrate for acquired amusia and highlight the importance of different temporal lobe regions for the recovery of amusia after stroke.The Society for Neuroscience2017201720162017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfhttps://hdl.handle.net/2445/109265Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1523/JNEUROSCI.0709-16.2016Journal of Neuroscience, 2016, vol. 36, num. 34, p. 8872-8881https://doi.org/10.1523/JNEUROSCI.0709-16.2016cc-by-nc-sa (c) Sihvonen, A.J. et al., 2016http://creativecommons.org/licenses/by-nc-sa/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1092652026-05-29T05:05:01Z
dc.title.none.fl_str_mv Neural basis of acquired amusia and its recovery after stroke
title Neural basis of acquired amusia and its recovery after stroke
spellingShingle Neural basis of acquired amusia and its recovery after stroke
Sihvonen, Aleksi J.
Mapatge del cervell
Lesions cerebrals
Afàsia
Brain mapping
Brain damage
Aphasia
title_short Neural basis of acquired amusia and its recovery after stroke
title_full Neural basis of acquired amusia and its recovery after stroke
title_fullStr Neural basis of acquired amusia and its recovery after stroke
title_full_unstemmed Neural basis of acquired amusia and its recovery after stroke
title_sort Neural basis of acquired amusia and its recovery after stroke
dc.creator.none.fl_str_mv Sihvonen, Aleksi J.
Ripollés, Pablo
Leo, Vera
Rodríguez Fornells, Antoni
Soinila, Seppo
Särkämö, Teppo
author Sihvonen, Aleksi J.
author_facet Sihvonen, Aleksi J.
Ripollés, Pablo
Leo, Vera
Rodríguez Fornells, Antoni
Soinila, Seppo
Särkämö, Teppo
author_role author
author2 Ripollés, Pablo
Leo, Vera
Rodríguez Fornells, Antoni
Soinila, Seppo
Särkämö, Teppo
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Mapatge del cervell
Lesions cerebrals
Afàsia
Brain mapping
Brain damage
Aphasia
topic Mapatge del cervell
Lesions cerebrals
Afàsia
Brain mapping
Brain damage
Aphasia
description Although acquired amusia is a relatively common disorder after stroke, its precise neuroanatomical basis is still unknown. To evaluate which brain regions form the neural substrate for acquired amusia and its recovery, we performed a voxel-based lesion-symptom mapping (VLSM) and morphometry (VBM) study with 77 human stroke subjects. Structural MRIs were acquired at acute and 6 month poststroke stages. Amusia and aphasia were behaviorally assessed at acute and 3 month poststroke stages using the Scale and Rhythm subtests of the Montreal Battery of Evaluation of Amusia (MBEA) and language tests. VLSM analyses indicated that amusia was associated with a lesion area comprising the superior temporal gyrus, Heschl's gyrus, insula, and striatum in the right hemisphere, clearly different from the lesion pattern associated with aphasia. Parametric analyses of MBEA Pitch and Rhythm scores showed extensive lesion overlap in the right striatum, as well as in the right Heschl's gyrus and superior temporal gyrus. Lesions associated with Rhythm scores extended more superiorly and posterolaterally. VBM analysis of volume changes from the acute to the 6 month stage showed a clear decrease in gray matter volume in the right superior and middle temporal gyri in nonrecovered amusic patients compared with nonamusic patients. This increased atrophy was more evident in anterior temporal areas in rhythm amusia and in posterior temporal and temporoparietal areas in pitch amusia. Overall, the results implicate right temporal and subcortical regions as the crucial neural substrate for acquired amusia and highlight the importance of different temporal lobe regions for the recovery of amusia after stroke.
publishDate 2016
dc.date.none.fl_str_mv 2016
2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/109265
url https://hdl.handle.net/2445/109265
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1523/JNEUROSCI.0709-16.2016
Journal of Neuroscience, 2016, vol. 36, num. 34, p. 8872-8881
https://doi.org/10.1523/JNEUROSCI.0709-16.2016
dc.rights.none.fl_str_mv cc-by-nc-sa (c) Sihvonen, A.J. et al., 2016
http://creativecommons.org/licenses/by-nc-sa/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-sa (c) Sihvonen, A.J. et al., 2016
http://creativecommons.org/licenses/by-nc-sa/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10 p.
application/pdf
dc.publisher.none.fl_str_mv The Society for Neuroscience
publisher.none.fl_str_mv The Society for Neuroscience
dc.source.none.fl_str_mv Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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