Oral lacosamide for the treatment of refractory trigeminal neuralgia: A retrospective analysis of 86 cases

Background and Objectives First-line treatment for trigeminal neuralgia (TN) is limited to carbamazepine and oxcarbazepine, and in refractory cases, alternatives are scarce. Lacosamide has been suggested as a valid option. In this study, we describe a series of patients who received oral lacosamide...

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Detalles Bibliográficos
Autores: Muñoz Vendrell, Albert, Tena Cucala, Raquel, Campoy Diaz, Sergio, García Parra, Belia, Prat, Joan, Martínez Yélamos, Sergio, Huerta Villanueva, Mariano
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/198616
Acceso en línea:https://hdl.handle.net/2445/198616
Access Level:acceso abierto
Palabra clave:Neuràlgia del trigemin
Tractament del dolor
Trigeminal neuralgia
Pain treatment
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spelling Oral lacosamide for the treatment of refractory trigeminal neuralgia: A retrospective analysis of 86 casesMuñoz Vendrell, AlbertTena Cucala, RaquelCampoy Diaz, SergioGarcía Parra, BeliaPrat, JoanMartínez Yélamos, SergioHuerta Villanueva, MarianoNeuràlgia del trigeminTractament del dolorTrigeminal neuralgiaPain treatmentBackground and Objectives First-line treatment for trigeminal neuralgia (TN) is limited to carbamazepine and oxcarbazepine, and in refractory cases, alternatives are scarce. Lacosamide has been suggested as a valid option. In this study, we describe a series of patients who received oral lacosamide as treatment for TN after first-line drug failure.Methods In this retrospective descriptive cohort study, we included patients with refractory TN who attended a tertiary center between 2015 and 2021 and were prescribed oral lacosamide after first-line treatment failure. The primary endpoints were pain relief and adverse effects. We secondarily analyzed clinical outcomes and compared responders versus nonresponders in the search for potential predictors of response.Results Eighty-six patients were included (mean age: 62 [SD 15.6] years; 54/86 [63%] female). The TN etiology was secondary in 16/86 (19%) patients. Concomitant continuous pain was present in 29/86 (34%) patients. The mean number of previous treatments was 2.7 [SD 1.5]. Pain relief was achieved in 57/86 (66%) cases, with 28/86 (33%) patients presenting adverse effects, all of which were mild. No statistically significant differences were observed between responders and nonresponders, but subtle clinical differences suggested potential predictors of response.Conclusion Lacosamide may be an effective and relatively safe treatment for refractory pain in TN patients after first-line treatment failure.Wiley2023202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion6 p.application/pdfhttps://hdl.handle.net/2445/198616Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1111/head.14505Headache: The Journal of Head and Face Pain, 2023, vol. 63, num. 4, p. 559-564https://doi.org/10.1111/head.14505cc by-nc-nd (c) Muñoz Vendrell, Albert et al., 2023http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1986162026-05-29T05:05:01Z
dc.title.none.fl_str_mv Oral lacosamide for the treatment of refractory trigeminal neuralgia: A retrospective analysis of 86 cases
title Oral lacosamide for the treatment of refractory trigeminal neuralgia: A retrospective analysis of 86 cases
spellingShingle Oral lacosamide for the treatment of refractory trigeminal neuralgia: A retrospective analysis of 86 cases
Muñoz Vendrell, Albert
Neuràlgia del trigemin
Tractament del dolor
Trigeminal neuralgia
Pain treatment
title_short Oral lacosamide for the treatment of refractory trigeminal neuralgia: A retrospective analysis of 86 cases
title_full Oral lacosamide for the treatment of refractory trigeminal neuralgia: A retrospective analysis of 86 cases
title_fullStr Oral lacosamide for the treatment of refractory trigeminal neuralgia: A retrospective analysis of 86 cases
title_full_unstemmed Oral lacosamide for the treatment of refractory trigeminal neuralgia: A retrospective analysis of 86 cases
title_sort Oral lacosamide for the treatment of refractory trigeminal neuralgia: A retrospective analysis of 86 cases
dc.creator.none.fl_str_mv Muñoz Vendrell, Albert
Tena Cucala, Raquel
Campoy Diaz, Sergio
García Parra, Belia
Prat, Joan
Martínez Yélamos, Sergio
Huerta Villanueva, Mariano
author Muñoz Vendrell, Albert
author_facet Muñoz Vendrell, Albert
Tena Cucala, Raquel
Campoy Diaz, Sergio
García Parra, Belia
Prat, Joan
Martínez Yélamos, Sergio
Huerta Villanueva, Mariano
author_role author
author2 Tena Cucala, Raquel
Campoy Diaz, Sergio
García Parra, Belia
Prat, Joan
Martínez Yélamos, Sergio
Huerta Villanueva, Mariano
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Neuràlgia del trigemin
Tractament del dolor
Trigeminal neuralgia
Pain treatment
topic Neuràlgia del trigemin
Tractament del dolor
Trigeminal neuralgia
Pain treatment
description Background and Objectives First-line treatment for trigeminal neuralgia (TN) is limited to carbamazepine and oxcarbazepine, and in refractory cases, alternatives are scarce. Lacosamide has been suggested as a valid option. In this study, we describe a series of patients who received oral lacosamide as treatment for TN after first-line drug failure.Methods In this retrospective descriptive cohort study, we included patients with refractory TN who attended a tertiary center between 2015 and 2021 and were prescribed oral lacosamide after first-line treatment failure. The primary endpoints were pain relief and adverse effects. We secondarily analyzed clinical outcomes and compared responders versus nonresponders in the search for potential predictors of response.Results Eighty-six patients were included (mean age: 62 [SD 15.6] years; 54/86 [63%] female). The TN etiology was secondary in 16/86 (19%) patients. Concomitant continuous pain was present in 29/86 (34%) patients. The mean number of previous treatments was 2.7 [SD 1.5]. Pain relief was achieved in 57/86 (66%) cases, with 28/86 (33%) patients presenting adverse effects, all of which were mild. No statistically significant differences were observed between responders and nonresponders, but subtle clinical differences suggested potential predictors of response.Conclusion Lacosamide may be an effective and relatively safe treatment for refractory pain in TN patients after first-line treatment failure.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/198616
url https://hdl.handle.net/2445/198616
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1111/head.14505
Headache: The Journal of Head and Face Pain, 2023, vol. 63, num. 4, p. 559-564
https://doi.org/10.1111/head.14505
dc.rights.none.fl_str_mv cc by-nc-nd (c) Muñoz Vendrell, Albert et al., 2023
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Muñoz Vendrell, Albert et al., 2023
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 6 p.
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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