Resumen de tesis. The MEK5/ERK5 pathway in lung and ovarian cancer

[EN] There is an obvious clinical need for unveiling novel pathophysiological mechanisms underlying lung and ovarian tumors that could foster the development of new targeted therapies and which, in turn, may positively impact the outcome of patients suffering from these severe diseases. Considering...

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Detalles Bibliográficos
Autor: Sánchez Fernández, Adrián
Tipo de recurso: tesis doctoral
Fecha de publicación:2021
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/151055
Acceso en línea:http://hdl.handle.net/10366/151055
Access Level:acceso abierto
Palabra clave:Tesis y disertaciones académicas
Universidad de Salamanca (España)
Tesis Doctoral
Academic dissertations
Ovarios
Pulmón
Cáncer
Early Detection of Cancer
Lung
Mitogen-Activated Protein Kinase Kinases
Ovarian Diseases
6310.03 Enfermedad
enfermedades del ovario
detección precoz del cáncer
pulmón
cinasas de proteína cinasa activada por mitógenos
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oai_identifier_str oai:gredos.usal.es:10366/151055
network_acronym_str ES
network_name_str España
repository_id_str
spelling Resumen de tesis. The MEK5/ERK5 pathway in lung and ovarian cancerThe MEK5/ERK5 pathway in lung and ovarian cancerLa vía de MEK5/ERK5 en cáncer de pulmón y ovarioSánchez Fernández, AdriánTesis y disertaciones académicasUniversidad de Salamanca (España)Tesis DoctoralAcademic dissertationsOvariosPulmónCáncerEarly Detection of CancerLungMitogen-Activated Protein Kinase KinasesOvarian Diseases6310.03 Enfermedadenfermedades del ovariodetección precoz del cáncerpulmóncinasas de proteína cinasa activada por mitógenos[EN] There is an obvious clinical need for unveiling novel pathophysiological mechanisms underlying lung and ovarian tumors that could foster the development of new targeted therapies and which, in turn, may positively impact the outcome of patients suffering from these severe diseases. Considering all the bibliographic precedents and the previous expertise of our laboratory on the study of the MEK5/ERK5 signaling pathway, the main objectives of this doctoral thesis project were: To develop a mouse model genetically engineered to express a constitutively active form of MEK5 to answer the question whether the sole activation of this signaling route promotes tumorigenesis. To study the functional relevance of the MEK5/ERK5 route in ovarian cancer.Esparís Ogando, Azucena202220222021info:eu-repo/semantics/doctoralThesishttp://hdl.handle.net/10366/151055reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1510552026-06-07T06:28:51Z
dc.title.none.fl_str_mv Resumen de tesis. The MEK5/ERK5 pathway in lung and ovarian cancer
The MEK5/ERK5 pathway in lung and ovarian cancer
La vía de MEK5/ERK5 en cáncer de pulmón y ovario
title Resumen de tesis. The MEK5/ERK5 pathway in lung and ovarian cancer
spellingShingle Resumen de tesis. The MEK5/ERK5 pathway in lung and ovarian cancer
Sánchez Fernández, Adrián
Tesis y disertaciones académicas
Universidad de Salamanca (España)
Tesis Doctoral
Academic dissertations
Ovarios
Pulmón
Cáncer
Early Detection of Cancer
Lung
Mitogen-Activated Protein Kinase Kinases
Ovarian Diseases
6310.03 Enfermedad
enfermedades del ovario
detección precoz del cáncer
pulmón
cinasas de proteína cinasa activada por mitógenos
title_short Resumen de tesis. The MEK5/ERK5 pathway in lung and ovarian cancer
title_full Resumen de tesis. The MEK5/ERK5 pathway in lung and ovarian cancer
title_fullStr Resumen de tesis. The MEK5/ERK5 pathway in lung and ovarian cancer
title_full_unstemmed Resumen de tesis. The MEK5/ERK5 pathway in lung and ovarian cancer
title_sort Resumen de tesis. The MEK5/ERK5 pathway in lung and ovarian cancer
dc.creator.none.fl_str_mv Sánchez Fernández, Adrián
author Sánchez Fernández, Adrián
author_facet Sánchez Fernández, Adrián
author_role author
dc.contributor.none.fl_str_mv Esparís Ogando, Azucena
dc.subject.none.fl_str_mv Tesis y disertaciones académicas
Universidad de Salamanca (España)
Tesis Doctoral
Academic dissertations
Ovarios
Pulmón
Cáncer
Early Detection of Cancer
Lung
Mitogen-Activated Protein Kinase Kinases
Ovarian Diseases
6310.03 Enfermedad
enfermedades del ovario
detección precoz del cáncer
pulmón
cinasas de proteína cinasa activada por mitógenos
topic Tesis y disertaciones académicas
Universidad de Salamanca (España)
Tesis Doctoral
Academic dissertations
Ovarios
Pulmón
Cáncer
Early Detection of Cancer
Lung
Mitogen-Activated Protein Kinase Kinases
Ovarian Diseases
6310.03 Enfermedad
enfermedades del ovario
detección precoz del cáncer
pulmón
cinasas de proteína cinasa activada por mitógenos
description [EN] There is an obvious clinical need for unveiling novel pathophysiological mechanisms underlying lung and ovarian tumors that could foster the development of new targeted therapies and which, in turn, may positively impact the outcome of patients suffering from these severe diseases. Considering all the bibliographic precedents and the previous expertise of our laboratory on the study of the MEK5/ERK5 signaling pathway, the main objectives of this doctoral thesis project were: To develop a mouse model genetically engineered to express a constitutively active form of MEK5 to answer the question whether the sole activation of this signaling route promotes tumorigenesis. To study the functional relevance of the MEK5/ERK5 route in ovarian cancer.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/151055
url http://hdl.handle.net/10366/151055
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869407234638741504
score 15,198674

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