Mechanical barriers and transforming growth factor beta inhibitor on epidural fibrosis in a rabbit laminectomy model
Background: TGF-β has been described as a mediator of fibrosis and scarring. Several studies achieved reduction in experimental scarring through the inhibition of TGF-β. Fibroblasts have been defined as the cell population originating fibrosis, blocking fibroblast invasion may impair epidural fibros...
| Autores: | , , , , , |
|---|---|
| Tipo de documento: | artigo |
| Data de publicação: | 2018 |
| País: | España |
| Recursos: | Universidad de Navarra |
| Repositório: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglês |
| OAI Identifier: | oai:dadun.unav.edu:10171/64851 |
| Acesso em linha: | https://hdl.handle.net/10171/64851 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Epidural fibrosis Laminectomy TGF-β Biomaterials |
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Mechanical barriers and transforming growth factor beta inhibitor on epidural fibrosis in a rabbit laminectomy modelAlbiñana-Cunningham, J.N. (Juan Newton)|||/items/30371efb-b285-437a-b529-56d93be82468Ripalda-Cemboráin, P. (Purificación)|||/items/844f1426-2ea0-484d-954c-08f0246aca72Labiano, T. (Tania)|||/items/d8a4e9ea-c62c-46a6-913e-44626df781b8Echeveste, J.I. (José I.)|||/items/37d13f4f-9c5d-4b46-84f1-6f449c18fb88Granero-Moltó, F. (Froilán)|||/items/9e969359-ca9a-4998-8e4a-bdf4037cba1aAlfonso-Olmos-García, M. (Matías)|||/items/4d8643fb-f0a2-449e-8383-659c19078445Epidural fibrosisLaminectomyTGF-βBiomaterialsBackground: TGF-β has been described as a mediator of fibrosis and scarring. Several studies achieved reduction in experimental scarring through the inhibition of TGF-β. Fibroblasts have been defined as the cell population originating fibrosis, blocking fibroblast invasion may impair epidural fibrosis appearance. For this purpose, biocompatible materials used as mechanical barriers and a TGF-β inhibitor peptide were evaluated in the reduction of epidural fibrosis. Methods: A L6 laminectomy was performed in 40 New Zealand white rabbits. Divided into four groups, each rabbit was assigned to receive either collagen sponge scaffold (CS group), gelatin-based gel (GCP group), P144® (iTGFβ group), or left untreated (control group). Four weeks after surgery, cell density, collagen content, and new bone formation of the scar area were determined by histomorphometry. Two experienced pathologists scored dura mater adhesion, scar density, and inflammatory infiltrate in a blinded manner. Results: In all groups, laminectomy site was filled with fibrous tissue and the dura mater presented adhesions. Only GCP group presented a significant reduction in collagen content and scar density. Conclusion: GCP treatment reduces epidural fibrosis although did not prevent dura mater adhesion completely.BioMed CentralDadun. Depósito Académico Digital Universidad de Navarra20222022-12-1420182018-01-0120182018-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/64851reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/648512026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Mechanical barriers and transforming growth factor beta inhibitor on epidural fibrosis in a rabbit laminectomy model |
| title |
Mechanical barriers and transforming growth factor beta inhibitor on epidural fibrosis in a rabbit laminectomy model |
| spellingShingle |
Mechanical barriers and transforming growth factor beta inhibitor on epidural fibrosis in a rabbit laminectomy model Albiñana-Cunningham, J.N. (Juan Newton)|||/items/30371efb-b285-437a-b529-56d93be82468 Epidural fibrosis Laminectomy TGF-β Biomaterials |
| title_short |
Mechanical barriers and transforming growth factor beta inhibitor on epidural fibrosis in a rabbit laminectomy model |
| title_full |
Mechanical barriers and transforming growth factor beta inhibitor on epidural fibrosis in a rabbit laminectomy model |
| title_fullStr |
Mechanical barriers and transforming growth factor beta inhibitor on epidural fibrosis in a rabbit laminectomy model |
| title_full_unstemmed |
Mechanical barriers and transforming growth factor beta inhibitor on epidural fibrosis in a rabbit laminectomy model |
| title_sort |
Mechanical barriers and transforming growth factor beta inhibitor on epidural fibrosis in a rabbit laminectomy model |
| dc.creator.none.fl_str_mv |
Albiñana-Cunningham, J.N. (Juan Newton)|||/items/30371efb-b285-437a-b529-56d93be82468 Ripalda-Cemboráin, P. (Purificación)|||/items/844f1426-2ea0-484d-954c-08f0246aca72 Labiano, T. (Tania)|||/items/d8a4e9ea-c62c-46a6-913e-44626df781b8 Echeveste, J.I. (José I.)|||/items/37d13f4f-9c5d-4b46-84f1-6f449c18fb88 Granero-Moltó, F. (Froilán)|||/items/9e969359-ca9a-4998-8e4a-bdf4037cba1a Alfonso-Olmos-García, M. (Matías)|||/items/4d8643fb-f0a2-449e-8383-659c19078445 |
| author |
Albiñana-Cunningham, J.N. (Juan Newton)|||/items/30371efb-b285-437a-b529-56d93be82468 |
| author_facet |
Albiñana-Cunningham, J.N. (Juan Newton)|||/items/30371efb-b285-437a-b529-56d93be82468 Ripalda-Cemboráin, P. (Purificación)|||/items/844f1426-2ea0-484d-954c-08f0246aca72 Labiano, T. (Tania)|||/items/d8a4e9ea-c62c-46a6-913e-44626df781b8 Echeveste, J.I. (José I.)|||/items/37d13f4f-9c5d-4b46-84f1-6f449c18fb88 Granero-Moltó, F. (Froilán)|||/items/9e969359-ca9a-4998-8e4a-bdf4037cba1a Alfonso-Olmos-García, M. (Matías)|||/items/4d8643fb-f0a2-449e-8383-659c19078445 |
| author_role |
author |
| author2 |
Ripalda-Cemboráin, P. (Purificación)|||/items/844f1426-2ea0-484d-954c-08f0246aca72 Labiano, T. (Tania)|||/items/d8a4e9ea-c62c-46a6-913e-44626df781b8 Echeveste, J.I. (José I.)|||/items/37d13f4f-9c5d-4b46-84f1-6f449c18fb88 Granero-Moltó, F. (Froilán)|||/items/9e969359-ca9a-4998-8e4a-bdf4037cba1a Alfonso-Olmos-García, M. (Matías)|||/items/4d8643fb-f0a2-449e-8383-659c19078445 |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Epidural fibrosis Laminectomy TGF-β Biomaterials |
| topic |
Epidural fibrosis Laminectomy TGF-β Biomaterials |
| description |
Background: TGF-β has been described as a mediator of fibrosis and scarring. Several studies achieved reduction in experimental scarring through the inhibition of TGF-β. Fibroblasts have been defined as the cell population originating fibrosis, blocking fibroblast invasion may impair epidural fibrosis appearance. For this purpose, biocompatible materials used as mechanical barriers and a TGF-β inhibitor peptide were evaluated in the reduction of epidural fibrosis. Methods: A L6 laminectomy was performed in 40 New Zealand white rabbits. Divided into four groups, each rabbit was assigned to receive either collagen sponge scaffold (CS group), gelatin-based gel (GCP group), P144® (iTGFβ group), or left untreated (control group). Four weeks after surgery, cell density, collagen content, and new bone formation of the scar area were determined by histomorphometry. Two experienced pathologists scored dura mater adhesion, scar density, and inflammatory infiltrate in a blinded manner. Results: In all groups, laminectomy site was filled with fibrous tissue and the dura mater presented adhesions. Only GCP group presented a significant reduction in collagen content and scar density. Conclusion: GCP treatment reduces epidural fibrosis although did not prevent dura mater adhesion completely. |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018 2018-01-01 2018 2018-01-01 2022 2022-12-14 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/64851 |
| url |
https://hdl.handle.net/10171/64851 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
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open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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BioMed Central |
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BioMed Central |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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15,300719 |