Protective Effect of Intestinal Helminthiasis Against Tuberculosis Progression Is Abrogated by Intermittent Food Deprivation

Tuberculosis (TB) is still a major challenge for humankind. Because regions with the highest incidence also have a high prevalence of helminthiasis and nutritional scarcity, we wanted to understand the impact of these on TB progression. We have developed an experimental murine model for active TB in...

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Autores: Garrido-Amaro, Cristina|||0000-0002-6506-4545, Cardona, Paula|||0000-0002-8613-9390, Gassó, Diana|||0000-0003-4553-8528, Arias, Lilibeth|||0000-0002-2469-8832, Velarde, Roser|||0000-0003-3332-6405, Tvarijonaviciute, Asta|||0000-0002-5323-5001, Serrano Ferron, Emmanuel|||0000-0002-9799-9804, Cardona, Pere-Joan|||0000-0001-5623-7873
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:255540
Acceso en línea:https://ddd.uab.cat/record/255540
https://dx.doi.org/urn:doi:10.3389/fimmu.2021.627638
Access Level:acceso abierto
Palabra clave:Co-infection
Tuberculosis
Trichuris muris
Heligmosomoides polygyrus
Environmental mycobacteria Mycobacterium manresensis
Fasting
C3HeB/FeJ
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spelling Protective Effect of Intestinal Helminthiasis Against Tuberculosis Progression Is Abrogated by Intermittent Food DeprivationGarrido-Amaro, Cristina|||0000-0002-6506-4545Cardona, Paula|||0000-0002-8613-9390Gassó, Diana|||0000-0003-4553-8528Arias, Lilibeth|||0000-0002-2469-8832Velarde, Roser|||0000-0003-3332-6405Tvarijonaviciute, Asta|||0000-0002-5323-5001Serrano Ferron, Emmanuel|||0000-0002-9799-9804Cardona, Pere-Joan|||0000-0001-5623-7873Co-infectionTuberculosisTrichuris murisHeligmosomoides polygyrusEnvironmental mycobacteria Mycobacterium manresensisFastingC3HeB/FeJTuberculosis (TB) is still a major challenge for humankind. Because regions with the highest incidence also have a high prevalence of helminthiasis and nutritional scarcity, we wanted to understand the impact of these on TB progression. We have developed an experimental murine model for active TB in C3HeB/FeJ, coinfected with Trichuris muris and Heligmosomoides polygyrus nematodes, and exposed to an environmental mycobacterium (M. manresensis) and intermittent fasting. Cause-effect relationships among these factors were explored with Partial Least Squares Path modelling (PLSPM). Previous parasitization had a major anti-inflammatory effect and reduced systemic levels of ADA, haptoglobin, local pulmonary levels of IL-1β, IL-6, TNF-α, CXCL-1, CXCL-5 and IL-10. Oral administration of heat-killed M. manresensis resulted in a similar outcome. Both interventions diminished pulmonary pathology and bacillary load, but intermittent food deprivation reduced this protective effect increasing stress and inflammation. The PLSPM revealed nematodes might have protective effects against TB progression. Significantly higher cortisol levels in food-deprivation groups showed it is a stressful condition, which might explain its deleterious effect. This highlights the impact of food security on TB eradication policies and the need to prioritize food supply over deworming activities. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/255540https://dx.doi.org/urn:doi:10.3389/fimmu.2021.627638reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-500Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 RYC-2016-21120Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 RYC-2017-22992open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2555402026-06-06T12:50:31Z
dc.title.none.fl_str_mv Protective Effect of Intestinal Helminthiasis Against Tuberculosis Progression Is Abrogated by Intermittent Food Deprivation
title Protective Effect of Intestinal Helminthiasis Against Tuberculosis Progression Is Abrogated by Intermittent Food Deprivation
spellingShingle Protective Effect of Intestinal Helminthiasis Against Tuberculosis Progression Is Abrogated by Intermittent Food Deprivation
Garrido-Amaro, Cristina|||0000-0002-6506-4545
Co-infection
Tuberculosis
Trichuris muris
Heligmosomoides polygyrus
Environmental mycobacteria Mycobacterium manresensis
Fasting
C3HeB/FeJ
title_short Protective Effect of Intestinal Helminthiasis Against Tuberculosis Progression Is Abrogated by Intermittent Food Deprivation
title_full Protective Effect of Intestinal Helminthiasis Against Tuberculosis Progression Is Abrogated by Intermittent Food Deprivation
title_fullStr Protective Effect of Intestinal Helminthiasis Against Tuberculosis Progression Is Abrogated by Intermittent Food Deprivation
title_full_unstemmed Protective Effect of Intestinal Helminthiasis Against Tuberculosis Progression Is Abrogated by Intermittent Food Deprivation
title_sort Protective Effect of Intestinal Helminthiasis Against Tuberculosis Progression Is Abrogated by Intermittent Food Deprivation
dc.creator.none.fl_str_mv Garrido-Amaro, Cristina|||0000-0002-6506-4545
Cardona, Paula|||0000-0002-8613-9390
Gassó, Diana|||0000-0003-4553-8528
Arias, Lilibeth|||0000-0002-2469-8832
Velarde, Roser|||0000-0003-3332-6405
Tvarijonaviciute, Asta|||0000-0002-5323-5001
Serrano Ferron, Emmanuel|||0000-0002-9799-9804
Cardona, Pere-Joan|||0000-0001-5623-7873
author Garrido-Amaro, Cristina|||0000-0002-6506-4545
author_facet Garrido-Amaro, Cristina|||0000-0002-6506-4545
Cardona, Paula|||0000-0002-8613-9390
Gassó, Diana|||0000-0003-4553-8528
Arias, Lilibeth|||0000-0002-2469-8832
Velarde, Roser|||0000-0003-3332-6405
Tvarijonaviciute, Asta|||0000-0002-5323-5001
Serrano Ferron, Emmanuel|||0000-0002-9799-9804
Cardona, Pere-Joan|||0000-0001-5623-7873
author_role author
author2 Cardona, Paula|||0000-0002-8613-9390
Gassó, Diana|||0000-0003-4553-8528
Arias, Lilibeth|||0000-0002-2469-8832
Velarde, Roser|||0000-0003-3332-6405
Tvarijonaviciute, Asta|||0000-0002-5323-5001
Serrano Ferron, Emmanuel|||0000-0002-9799-9804
Cardona, Pere-Joan|||0000-0001-5623-7873
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Co-infection
Tuberculosis
Trichuris muris
Heligmosomoides polygyrus
Environmental mycobacteria Mycobacterium manresensis
Fasting
C3HeB/FeJ
topic Co-infection
Tuberculosis
Trichuris muris
Heligmosomoides polygyrus
Environmental mycobacteria Mycobacterium manresensis
Fasting
C3HeB/FeJ
description Tuberculosis (TB) is still a major challenge for humankind. Because regions with the highest incidence also have a high prevalence of helminthiasis and nutritional scarcity, we wanted to understand the impact of these on TB progression. We have developed an experimental murine model for active TB in C3HeB/FeJ, coinfected with Trichuris muris and Heligmosomoides polygyrus nematodes, and exposed to an environmental mycobacterium (M. manresensis) and intermittent fasting. Cause-effect relationships among these factors were explored with Partial Least Squares Path modelling (PLSPM). Previous parasitization had a major anti-inflammatory effect and reduced systemic levels of ADA, haptoglobin, local pulmonary levels of IL-1β, IL-6, TNF-α, CXCL-1, CXCL-5 and IL-10. Oral administration of heat-killed M. manresensis resulted in a similar outcome. Both interventions diminished pulmonary pathology and bacillary load, but intermittent food deprivation reduced this protective effect increasing stress and inflammation. The PLSPM revealed nematodes might have protective effects against TB progression. Significantly higher cortisol levels in food-deprivation groups showed it is a stressful condition, which might explain its deleterious effect. This highlights the impact of food security on TB eradication policies and the need to prioritize food supply over deworming activities.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/255540
https://dx.doi.org/urn:doi:10.3389/fimmu.2021.627638
url https://ddd.uab.cat/record/255540
https://dx.doi.org/urn:doi:10.3389/fimmu.2021.627638
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-500
Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 RYC-2016-21120
Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 RYC-2017-22992
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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