L’àcid úric, el greix perirenal i la mida renal com a nous marcadors de risc cardiovascular en població pediàtrica sana
Despite notable advances in health promotion over the past decades, cardiovascular disease remains the leading cause of death worldwide, with obesity being a rising contributor of it. Cardiovascular risk factors appear in early life, and their detection in the pediatric age is really important to id...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/675981 |
| Acceso en línea: | http://hdl.handle.net/10803/675981 |
| Access Level: | acceso abierto |
| Palabra clave: | Àcid úric Ácido úrico Uric acid Greix perirenal Grasa perirrenal Perirenal fat Mida renal Tamaño renal Renal size Gruix íntima-mitjana carotídia Grosor íntima-mediana carotídea Carotid intima-media thickness Risc cardiovascular Riesgo cardiovascular Cardiovascular risk Pediatria Pediatría Pediatrics Obesitat Obesidad Obesity 616.1 616.4 616.6 |
| Sumario: | Despite notable advances in health promotion over the past decades, cardiovascular disease remains the leading cause of death worldwide, with obesity being a rising contributor of it. Cardiovascular risk factors appear in early life, and their detection in the pediatric age is really important to identify the risk population and to develop new primary prevention strategies. We aimed to identify novel markers than can be easily assessed and used in the clinical evaluation and early prevention of cardiovascular disease in the pediatric population. Specifically, we have studied the relationship of uric acid, perirenal fat and kidney size with carotid intima-media thickness (cIMT; a marker of subclinical atherosclerosis) and classical cardiovascular risk factors in a cohort of 702 healthy prepubertal children with and without overweight and obesity. Our results show that 1) uric acid levels are associated with several cardiovascular risk factors and are independent predictors of cIMT, especially in children with higher body mass index (BMI) and higher preperitoneal fat; 2) perirenal fat is the main abdominal fat depot associated with cIMT, especially in overweight and obese children; 3) renal size (length and volume) also are associated with several cardiovascular risk factors and showed independent associations with cIMT and systolic blood pressure (SBP) in obese children. In conclusion, serum uric acid levels, perirenal fat, and kidney size are associated with various cardiovascular risk factors, especially in children with overweight and obesity, and may thus represent useful parameters for assessing cardiovascular risk and the onset of atherosclerotic disease in healthy children |
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