Characterization of the Antiglioma Effect of the Oncolytic Adenovirus VCN-01

Despite the recent advances in the development of antitumor therapies, the prognosis for patients with malignant gliomas remains dismal. Therapy with tumor-selective viruses is emerging as a treatment option for this devastating disease. In this study we characterize the anti-glioma effect of VCN-01...

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Authors: Vera, Beatriz, Martínez Vélez, Naiara, Xipell, Enric, Acanda de la Rocha, Arlet, Patiño García, Ana, Saez Castresana, Javier, Gonzalez Huarriz, Marisol, Cascallò, Manel, Alemany Bonastre, Ramon, Alonso, Marta M.
Format: article
Status:Published version
Publication Date:2016
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/126898
Online Access:https://hdl.handle.net/2445/126898
Access Level:Open access
Keyword:Glioma
Adenovirus
Gliomas
Adenoviruses
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spelling Characterization of the Antiglioma Effect of the Oncolytic Adenovirus VCN-01Vera, BeatrizMartínez Vélez, NaiaraXipell, EnricAcanda de la Rocha, ArletPatiño García, AnaSaez Castresana, JavierGonzalez Huarriz, MarisolCascallò, ManelAlemany Bonastre, RamonAlonso, Marta M.GliomaAdenovirusGliomasAdenovirusesDespite the recent advances in the development of antitumor therapies, the prognosis for patients with malignant gliomas remains dismal. Therapy with tumor-selective viruses is emerging as a treatment option for this devastating disease. In this study we characterize the anti-glioma effect of VCN-01, an improved hyaluronidase-armed pRB-pathway-selective oncolytic adenovirus that has proven safe and effective in the treatment of several solid tumors. VCN-01 displayed a significant cytotoxic effect on glioma cells in vitro. In vivo, in two different orthotopic glioma models, a single intra-tumoral administration of VCN-01 increased overall survival significantly and led to long-term survivors free of disease.Public Library of Science (PLoS)2018201820162018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/126898Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0147211PLoS One, 2016, vol. 11, num. 1, p. e0147211https://doi.org/10.1371/journal.pone.0147211cc by (c) Vera et al., 2016http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1268982026-05-29T05:05:01Z
dc.title.none.fl_str_mv Characterization of the Antiglioma Effect of the Oncolytic Adenovirus VCN-01
title Characterization of the Antiglioma Effect of the Oncolytic Adenovirus VCN-01
spellingShingle Characterization of the Antiglioma Effect of the Oncolytic Adenovirus VCN-01
Vera, Beatriz
Glioma
Adenovirus
Gliomas
Adenoviruses
title_short Characterization of the Antiglioma Effect of the Oncolytic Adenovirus VCN-01
title_full Characterization of the Antiglioma Effect of the Oncolytic Adenovirus VCN-01
title_fullStr Characterization of the Antiglioma Effect of the Oncolytic Adenovirus VCN-01
title_full_unstemmed Characterization of the Antiglioma Effect of the Oncolytic Adenovirus VCN-01
title_sort Characterization of the Antiglioma Effect of the Oncolytic Adenovirus VCN-01
dc.creator.none.fl_str_mv Vera, Beatriz
Martínez Vélez, Naiara
Xipell, Enric
Acanda de la Rocha, Arlet
Patiño García, Ana
Saez Castresana, Javier
Gonzalez Huarriz, Marisol
Cascallò, Manel
Alemany Bonastre, Ramon
Alonso, Marta M.
author Vera, Beatriz
author_facet Vera, Beatriz
Martínez Vélez, Naiara
Xipell, Enric
Acanda de la Rocha, Arlet
Patiño García, Ana
Saez Castresana, Javier
Gonzalez Huarriz, Marisol
Cascallò, Manel
Alemany Bonastre, Ramon
Alonso, Marta M.
author_role author
author2 Martínez Vélez, Naiara
Xipell, Enric
Acanda de la Rocha, Arlet
Patiño García, Ana
Saez Castresana, Javier
Gonzalez Huarriz, Marisol
Cascallò, Manel
Alemany Bonastre, Ramon
Alonso, Marta M.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Glioma
Adenovirus
Gliomas
Adenoviruses
topic Glioma
Adenovirus
Gliomas
Adenoviruses
description Despite the recent advances in the development of antitumor therapies, the prognosis for patients with malignant gliomas remains dismal. Therapy with tumor-selective viruses is emerging as a treatment option for this devastating disease. In this study we characterize the anti-glioma effect of VCN-01, an improved hyaluronidase-armed pRB-pathway-selective oncolytic adenovirus that has proven safe and effective in the treatment of several solid tumors. VCN-01 displayed a significant cytotoxic effect on glioma cells in vitro. In vivo, in two different orthotopic glioma models, a single intra-tumoral administration of VCN-01 increased overall survival significantly and led to long-term survivors free of disease.
publishDate 2016
dc.date.none.fl_str_mv 2016
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/126898
url https://hdl.handle.net/2445/126898
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0147211
PLoS One, 2016, vol. 11, num. 1, p. e0147211
https://doi.org/10.1371/journal.pone.0147211
dc.rights.none.fl_str_mv cc by (c) Vera et al., 2016
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Vera et al., 2016
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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