Hydroxytyrosol improves mitochondrial energetics of a cellular model of Alzheimer’s disease

Mitochondrial energetic deficit is one of the hallmarks of neurodegenerative disorders, e.g. Alzheimer´s disease (AD). Adherence to a Mediterranean diet is associated with lower incidence of cognitive decline and AD and extra virgin olive oil’s (poly)phenols such as oleuropein and hydroxytyrosol (HT...

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Detalhes bibliográficos
Autores: Visioli, Francesco, Rodríguez Pérez, María, Gómez Torres, Óscar, Pintado Losa, Cristina, Burgos Ramos, Emma
Formato: artículo
Fecha de publicación:2020
País:España
Recursos:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/29412
Acesso em linha:http://hdl.handle.net/10578/29412
Access Level:acceso abierto
Palavra-chave:Hydroxytyrosol
Mitochondria
Alzheimer´s disease
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spelling Hydroxytyrosol improves mitochondrial energetics of a cellular model of Alzheimer’s diseaseVisioli, FrancescoRodríguez Pérez, MaríaGómez Torres, ÓscarPintado Losa, CristinaBurgos Ramos, EmmaHydroxytyrosolMitochondriaAlzheimer´s diseaseMitochondrial energetic deficit is one of the hallmarks of neurodegenerative disorders, e.g. Alzheimer´s disease (AD). Adherence to a Mediterranean diet is associated with lower incidence of cognitive decline and AD and extra virgin olive oil’s (poly)phenols such as oleuropein and hydroxytyrosol (HT) are being actively studied in this respect. In this study, we assessed the effects of HT on mitochondrial energetic dysfunction in the 7PA2 cells cellular model, i.e. one of the best cellular models of Aβ toxicity with a well-characterized mitochondrial dysfunction typically observed in AD. We report an increase of new mitochondria at 8 h post HT-treatment, which was followed by higher mitochondrial fusion. Further, ATP concentrations were significantly increased after 24 h of treatment with HT as compared with controls. Our data suggest that HT may revert the energetic deficit of a cellular model of AD by potentiating mitochondrial activity. Because HT is being proposed as dietary supplement or component of functional foods, future studies in appropriate animal models and – eventually – humans are warranted to further investigate its potential neuroprotective actions in AD.Taylor and Francis202220222020info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10578/29412reponame:RUIdeRA. Repositorio Institucional de la UCLMinstname:Universidad de Castilla-La ManchaInglésinfo:eu-repo/semantics/openAccessoai:ruidera.uclm.es:10578/294122026-05-27T07:36:41Z
dc.title.none.fl_str_mv Hydroxytyrosol improves mitochondrial energetics of a cellular model of Alzheimer’s disease
title Hydroxytyrosol improves mitochondrial energetics of a cellular model of Alzheimer’s disease
spellingShingle Hydroxytyrosol improves mitochondrial energetics of a cellular model of Alzheimer’s disease
Visioli, Francesco
Hydroxytyrosol
Mitochondria
Alzheimer´s disease
title_short Hydroxytyrosol improves mitochondrial energetics of a cellular model of Alzheimer’s disease
title_full Hydroxytyrosol improves mitochondrial energetics of a cellular model of Alzheimer’s disease
title_fullStr Hydroxytyrosol improves mitochondrial energetics of a cellular model of Alzheimer’s disease
title_full_unstemmed Hydroxytyrosol improves mitochondrial energetics of a cellular model of Alzheimer’s disease
title_sort Hydroxytyrosol improves mitochondrial energetics of a cellular model of Alzheimer’s disease
dc.creator.none.fl_str_mv Visioli, Francesco
Rodríguez Pérez, María
Gómez Torres, Óscar
Pintado Losa, Cristina
Burgos Ramos, Emma
author Visioli, Francesco
author_facet Visioli, Francesco
Rodríguez Pérez, María
Gómez Torres, Óscar
Pintado Losa, Cristina
Burgos Ramos, Emma
author_role author
author2 Rodríguez Pérez, María
Gómez Torres, Óscar
Pintado Losa, Cristina
Burgos Ramos, Emma
author2_role author
author
author
author
dc.subject.none.fl_str_mv Hydroxytyrosol
Mitochondria
Alzheimer´s disease
topic Hydroxytyrosol
Mitochondria
Alzheimer´s disease
description Mitochondrial energetic deficit is one of the hallmarks of neurodegenerative disorders, e.g. Alzheimer´s disease (AD). Adherence to a Mediterranean diet is associated with lower incidence of cognitive decline and AD and extra virgin olive oil’s (poly)phenols such as oleuropein and hydroxytyrosol (HT) are being actively studied in this respect. In this study, we assessed the effects of HT on mitochondrial energetic dysfunction in the 7PA2 cells cellular model, i.e. one of the best cellular models of Aβ toxicity with a well-characterized mitochondrial dysfunction typically observed in AD. We report an increase of new mitochondria at 8 h post HT-treatment, which was followed by higher mitochondrial fusion. Further, ATP concentrations were significantly increased after 24 h of treatment with HT as compared with controls. Our data suggest that HT may revert the energetic deficit of a cellular model of AD by potentiating mitochondrial activity. Because HT is being proposed as dietary supplement or component of functional foods, future studies in appropriate animal models and – eventually – humans are warranted to further investigate its potential neuroprotective actions in AD.
publishDate 2020
dc.date.none.fl_str_mv 2020
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10578/29412
url http://hdl.handle.net/10578/29412
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor and Francis
publisher.none.fl_str_mv Taylor and Francis
dc.source.none.fl_str_mv reponame:RUIdeRA. Repositorio Institucional de la UCLM
instname:Universidad de Castilla-La Mancha
instname_str Universidad de Castilla-La Mancha
reponame_str RUIdeRA. Repositorio Institucional de la UCLM
collection RUIdeRA. Repositorio Institucional de la UCLM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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