Functional structure of local connections and differentiation of cerebral cortex areas in the neonate

Neuroimaging research on functional connectivity can provide valuable information on the developmental differentiation of the infant cerebral cortex into its functional areas. We examined healthy neonates to comprehensively map brain functional connectivity using a combination of local measures that...

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Authors: Falcón Falcón, Carles Maria, Pujol Nuez, Jesús, Blanco Hinojo, Laura, Persavento, Cecilia, Martínez Vilavella, Gerard, Gascón, Mireia, Rivas, Ioar, Vilanova, Marc, Deus Yela, Juan, Gispert, Juan Domingo, Gómez Roig, Ma. Dolores, Llurba Olivé, Elisa, Dadvand, Payam, Sunyer, Jordi
Format: article
Status:Published version
Publication Date:2024
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/223843
Online Access:https://hdl.handle.net/2445/223843
Access Level:Open access
Keyword:Escorça cerebral
Mapatge del cervell
Infants nadons
Cerebral cortex
Brain mapping
Newborn infants
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spelling Functional structure of local connections and differentiation of cerebral cortex areas in the neonateFalcón Falcón, Carles MariaPujol Nuez, JesúsBlanco Hinojo, LauraPersavento, CeciliaMartínez Vilavella, GerardGascón, MireiaRivas, IoarVilanova, MarcDeus Yela, JuanGispert, Juan DomingoGómez Roig, Ma. DoloresLlurba Olivé, ElisaDadvand, PayamSunyer, JordiEscorça cerebralMapatge del cervellInfants nadonsCerebral cortexBrain mappingNewborn infantsNeuroimaging research on functional connectivity can provide valuable information on the developmental differentiation of the infant cerebral cortex into its functional areas. We examined healthy neonates to comprehensively map brain functional connectivity using a combination of local measures that uniquely capture the rich spatial structure of cerebral cortex functional connections. Optimal functional MRI scans were obtained in 61 neonates. Local functional connectivity maps were based on Iso-Distance Average Correlation (IDAC) measures. Single distance maps and maps combining three distinct IDAC measures were used to assess different levels of cortical area functional differentiation. A set of brain areas showed higher connectivity than the rest of the brain parenchyma in each local distance map. These areas were consistent with those supporting basic aspects of the neonatal repertoire of adaptive behaviors and included the sensorimotor, auditory and visual cortices, the frontal operculum/anterior insula (relevant for sucking, swallowing and the sense of taste), paracentral lobule (processing anal and urethral sphincter activity), default mode network (relevant for self-awareness), and limbicemotional structures such as the anterior cingulate cortex, amygdala and hippocampus. However, the results also indicate that brain areas presumed to be actively developing may not necessarily be mature. In fact, combined distance, second-level maps confirmed that the functional differentiation of the cerebral cortex into functional areas in neonates is far from complete. Our results provide a more comprehensive understanding of the developing brain systems, while also highlighting the substantial developmental journey that the neonatal brain must undergo to reach adulthood.Elsevier B.V.2025202520242025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion9 p.application/pdfhttps://hdl.handle.net/2445/223843Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.neuroimage.2024.120780Neuroimage, 2024, vol. 298https://doi.org/10.1016/j.neuroimage.2024.120780cc-by-nc-nd (c) Pujol, J. et al., 2024http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2238432026-05-29T05:05:01Z
dc.title.none.fl_str_mv Functional structure of local connections and differentiation of cerebral cortex areas in the neonate
title Functional structure of local connections and differentiation of cerebral cortex areas in the neonate
spellingShingle Functional structure of local connections and differentiation of cerebral cortex areas in the neonate
Falcón Falcón, Carles Maria
Escorça cerebral
Mapatge del cervell
Infants nadons
Cerebral cortex
Brain mapping
Newborn infants
title_short Functional structure of local connections and differentiation of cerebral cortex areas in the neonate
title_full Functional structure of local connections and differentiation of cerebral cortex areas in the neonate
title_fullStr Functional structure of local connections and differentiation of cerebral cortex areas in the neonate
title_full_unstemmed Functional structure of local connections and differentiation of cerebral cortex areas in the neonate
title_sort Functional structure of local connections and differentiation of cerebral cortex areas in the neonate
dc.creator.none.fl_str_mv Falcón Falcón, Carles Maria
Pujol Nuez, Jesús
Blanco Hinojo, Laura
Persavento, Cecilia
Martínez Vilavella, Gerard
Gascón, Mireia
Rivas, Ioar
Vilanova, Marc
Deus Yela, Juan
Gispert, Juan Domingo
Gómez Roig, Ma. Dolores
Llurba Olivé, Elisa
Dadvand, Payam
Sunyer, Jordi
author Falcón Falcón, Carles Maria
author_facet Falcón Falcón, Carles Maria
Pujol Nuez, Jesús
Blanco Hinojo, Laura
Persavento, Cecilia
Martínez Vilavella, Gerard
Gascón, Mireia
Rivas, Ioar
Vilanova, Marc
Deus Yela, Juan
Gispert, Juan Domingo
Gómez Roig, Ma. Dolores
Llurba Olivé, Elisa
Dadvand, Payam
Sunyer, Jordi
author_role author
author2 Pujol Nuez, Jesús
Blanco Hinojo, Laura
Persavento, Cecilia
Martínez Vilavella, Gerard
Gascón, Mireia
Rivas, Ioar
Vilanova, Marc
Deus Yela, Juan
Gispert, Juan Domingo
Gómez Roig, Ma. Dolores
Llurba Olivé, Elisa
Dadvand, Payam
Sunyer, Jordi
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Escorça cerebral
Mapatge del cervell
Infants nadons
Cerebral cortex
Brain mapping
Newborn infants
topic Escorça cerebral
Mapatge del cervell
Infants nadons
Cerebral cortex
Brain mapping
Newborn infants
description Neuroimaging research on functional connectivity can provide valuable information on the developmental differentiation of the infant cerebral cortex into its functional areas. We examined healthy neonates to comprehensively map brain functional connectivity using a combination of local measures that uniquely capture the rich spatial structure of cerebral cortex functional connections. Optimal functional MRI scans were obtained in 61 neonates. Local functional connectivity maps were based on Iso-Distance Average Correlation (IDAC) measures. Single distance maps and maps combining three distinct IDAC measures were used to assess different levels of cortical area functional differentiation. A set of brain areas showed higher connectivity than the rest of the brain parenchyma in each local distance map. These areas were consistent with those supporting basic aspects of the neonatal repertoire of adaptive behaviors and included the sensorimotor, auditory and visual cortices, the frontal operculum/anterior insula (relevant for sucking, swallowing and the sense of taste), paracentral lobule (processing anal and urethral sphincter activity), default mode network (relevant for self-awareness), and limbicemotional structures such as the anterior cingulate cortex, amygdala and hippocampus. However, the results also indicate that brain areas presumed to be actively developing may not necessarily be mature. In fact, combined distance, second-level maps confirmed that the functional differentiation of the cerebral cortex into functional areas in neonates is far from complete. Our results provide a more comprehensive understanding of the developing brain systems, while also highlighting the substantial developmental journey that the neonatal brain must undergo to reach adulthood.
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/223843
url https://hdl.handle.net/2445/223843
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.neuroimage.2024.120780
Neuroimage, 2024, vol. 298
https://doi.org/10.1016/j.neuroimage.2024.120780
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Pujol, J. et al., 2024
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Pujol, J. et al., 2024
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869407197468819456
score 15,811543

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