Semi-solid functionalized nanostructured lipid carriers loading thymol for skin disorders

Folle, Camila; Sánchez-López, E. (Elena); Mallandrich Miret, Mireia; Díaz-Garrido, Natalia; Suñer Carbó, J. (Joaquim); Halbaut, Lyda; Carvajal Vidal, Paulina Andrea; Marqués Villavecchia, Ana M.; Espina García, Marta; Badía Palacín, Josefa; Baldomà Llavinés, Laura; García López, María Luisa; Calpena Campmany, Ana Cristina

Semi-solid functionalized nanostructured lipid carriers loading thymol for skin disorders

Acne constitutes one of the most prevalent skin disorder affecting both skin and mental health of patients. However, no cure has been developed so far. In this area, Thymol constitutes a potential candidate since it is able to restore the healthy microbiota of the skin. However, its permeation prope...

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Detalles Bibliográficos
Autores:	Folle, Camila, Sánchez-López, E. (Elena), Mallandrich Miret, Mireia, Díaz-Garrido, Natalia, Suñer Carbó, J. (Joaquim), Halbaut, Lyda, Carvajal Vidal, Paulina Andrea, Marqués Villavecchia, Ana M., Espina García, Marta, Badía Palacín, Josefa, Baldomà Llavinés, Laura, García López, María Luisa, Calpena Campmany, Ana Cristina
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2024
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/219683
Acceso en línea:	https://hdl.handle.net/2445/219683
Access Level:	acceso abierto
Palabra clave:	Pell Nanopartícules Emulsions (Farmàcia) Skin Nanoparticles Emulsions (Pharmacy)

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spelling	Semi-solid functionalized nanostructured lipid carriers loading thymol for skin disordersFolle, CamilaSánchez-López, E. (Elena)Mallandrich Miret, MireiaDíaz-Garrido, NataliaSuñer Carbó, J. (Joaquim)Halbaut, LydaCarvajal Vidal, Paulina AndreaMarqués Villavecchia, Ana M.Espina García, MartaBadía Palacín, JosefaBaldomà Llavinés, LauraGarcía López, María LuisaCalpena Campmany, Ana CristinaPellNanopartículesEmulsions (Farmàcia)SkinNanoparticlesEmulsions (Pharmacy)Acne constitutes one of the most prevalent skin disorder affecting both skin and mental health of patients. However, no cure has been developed so far. In this area, Thymol constitutes a potential candidate since it is able to restore the healthy microbiota of the skin. However, its permeation properties cause its fast elimination and, to avoid this problem, thymol has been loaded into nanostructured lipid carriers (TH-NLCs). Moreover, to increase the suitability of these systems for skin applications, several surface functionalization strategies of TH-NLCs had been assessed. Among the different molecules, phosphatidylcholine-TH-NLCs demonstrated to be safe as well as to provide high antioxidant activity in cellular studies. Therefore, to administer these systems to the skin, functionalized TH-NLCs were dispersed into a carbomer gel developing semi-solid formulations. Rheological properties, porosity and extensibility of TH dispersed in carbomer as well as phosphatidylcholine-TH-NLCs were assessed demonstrating suitable properties for dermal applications. Moreover, both formulations were applied in healthy volunteers demonstrating that gel-phosphatidylcholine-TH-NLCs were able to increase in skin hydration, decrease water loss and reduce skin sebum. Therefore, gel-phosphatidylcholine-TH-NLCs proved to be a suitable system for skin pathologies linked with high sebum generation, loss of hydration and high oxidation, such as acne vulgaris. Keywords: Acne; Dermal; Lipid nanoparticles; Nanostructured lipid carriers; Thymol.Elsevier B.V.2025202520242025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1 p.application/pdfhttps://hdl.handle.net/2445/219683Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.ijpharm.2023.123732International Journal of Pharmaceutics, 2024, vol. 651https://doi.org/10.1016/j.ijpharm.2023.123732cc-by-nc-nd (c) Camila Folle, et al., 2024http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2196832026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Semi-solid functionalized nanostructured lipid carriers loading thymol for skin disorders
title	Semi-solid functionalized nanostructured lipid carriers loading thymol for skin disorders
spellingShingle	Semi-solid functionalized nanostructured lipid carriers loading thymol for skin disorders Folle, Camila Pell Nanopartícules Emulsions (Farmàcia) Skin Nanoparticles Emulsions (Pharmacy)
title_short	Semi-solid functionalized nanostructured lipid carriers loading thymol for skin disorders
title_full	Semi-solid functionalized nanostructured lipid carriers loading thymol for skin disorders
title_fullStr	Semi-solid functionalized nanostructured lipid carriers loading thymol for skin disorders
title_full_unstemmed	Semi-solid functionalized nanostructured lipid carriers loading thymol for skin disorders
title_sort	Semi-solid functionalized nanostructured lipid carriers loading thymol for skin disorders
dc.creator.none.fl_str_mv	Folle, Camila Sánchez-López, E. (Elena) Mallandrich Miret, Mireia Díaz-Garrido, Natalia Suñer Carbó, J. (Joaquim) Halbaut, Lyda Carvajal Vidal, Paulina Andrea Marqués Villavecchia, Ana M. Espina García, Marta Badía Palacín, Josefa Baldomà Llavinés, Laura García López, María Luisa Calpena Campmany, Ana Cristina
author	Folle, Camila
author_facet	Folle, Camila Sánchez-López, E. (Elena) Mallandrich Miret, Mireia Díaz-Garrido, Natalia Suñer Carbó, J. (Joaquim) Halbaut, Lyda Carvajal Vidal, Paulina Andrea Marqués Villavecchia, Ana M. Espina García, Marta Badía Palacín, Josefa Baldomà Llavinés, Laura García López, María Luisa Calpena Campmany, Ana Cristina
author_role	author
author2	Sánchez-López, E. (Elena) Mallandrich Miret, Mireia Díaz-Garrido, Natalia Suñer Carbó, J. (Joaquim) Halbaut, Lyda Carvajal Vidal, Paulina Andrea Marqués Villavecchia, Ana M. Espina García, Marta Badía Palacín, Josefa Baldomà Llavinés, Laura García López, María Luisa Calpena Campmany, Ana Cristina
author2_role	author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Pell Nanopartícules Emulsions (Farmàcia) Skin Nanoparticles Emulsions (Pharmacy)
topic	Pell Nanopartícules Emulsions (Farmàcia) Skin Nanoparticles Emulsions (Pharmacy)
description	Acne constitutes one of the most prevalent skin disorder affecting both skin and mental health of patients. However, no cure has been developed so far. In this area, Thymol constitutes a potential candidate since it is able to restore the healthy microbiota of the skin. However, its permeation properties cause its fast elimination and, to avoid this problem, thymol has been loaded into nanostructured lipid carriers (TH-NLCs). Moreover, to increase the suitability of these systems for skin applications, several surface functionalization strategies of TH-NLCs had been assessed. Among the different molecules, phosphatidylcholine-TH-NLCs demonstrated to be safe as well as to provide high antioxidant activity in cellular studies. Therefore, to administer these systems to the skin, functionalized TH-NLCs were dispersed into a carbomer gel developing semi-solid formulations. Rheological properties, porosity and extensibility of TH dispersed in carbomer as well as phosphatidylcholine-TH-NLCs were assessed demonstrating suitable properties for dermal applications. Moreover, both formulations were applied in healthy volunteers demonstrating that gel-phosphatidylcholine-TH-NLCs were able to increase in skin hydration, decrease water loss and reduce skin sebum. Therefore, gel-phosphatidylcholine-TH-NLCs proved to be a suitable system for skin pathologies linked with high sebum generation, loss of hydration and high oxidation, such as acne vulgaris. Keywords: Acne; Dermal; Lipid nanoparticles; Nanostructured lipid carriers; Thymol.
publishDate	2024
dc.date.none.fl_str_mv	2024 2025 2025 2025
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/219683
url	https://hdl.handle.net/2445/219683
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.1016/j.ijpharm.2023.123732 International Journal of Pharmaceutics, 2024, vol. 651 https://doi.org/10.1016/j.ijpharm.2023.123732
dc.rights.none.fl_str_mv	cc-by-nc-nd (c) Camila Folle, et al., 2024 http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc-by-nc-nd (c) Camila Folle, et al., 2024 http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	1 p. application/pdf
dc.publisher.none.fl_str_mv	Elsevier B.V.
publisher.none.fl_str_mv	Elsevier B.V.
dc.source.none.fl_str_mv	Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,811543

Semi-solid functionalized nanostructured lipid carriers loading thymol for skin disorders

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