Fatty acids in the placenta of appropiate- versus small-for-gestational-age infants at term birth

Introduction: Fatty acids are essential nutrients for the fetus and are supplied by the mother through the placenta. Desaturase and elongase enzymes play an important role in modulating the fatty acid composition of body tissues. We aimed to compare the fatty acid profile and the estimated desaturas...

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Autores: Gómez Vilarrubla, Ariadna, Mas Parés, Berta, Díaz, Marta, Xargay Torrent, Sílvia, Carreras Badosa, Gemma, Jové Font, Mariona, Martín Garí, Meritxell, Bonmatí Santané, Alexandra, Zegher, Francis de, Ibáñez, Lourdes, López Bermejo, Abel, Bassols, Judit
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/72405
Acceso en línea:https://doi.org/10.1016/j.placenta.2021.04.009
http://hdl.handle.net/10459.1/72405
Access Level:acceso abierto
Palabra clave:Placenta
Fatty acids
SGA
Desaturase and elongase
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spelling Fatty acids in the placenta of appropiate- versus small-for-gestational-age infants at term birthGómez Vilarrubla, AriadnaMas Parés, BertaDíaz, MartaXargay Torrent, SílviaCarreras Badosa, GemmaJové Font, MarionaMartín Garí, MeritxellBonmatí Santané, AlexandraZegher, Francis deIbáñez, Lourdes López Bermejo, AbelBassols, JuditPlacentaFatty acidsSGADesaturase and elongaseIntroduction: Fatty acids are essential nutrients for the fetus and are supplied by the mother through the placenta. Desaturase and elongase enzymes play an important role in modulating the fatty acid composition of body tissues. We aimed to compare the fatty acid profile and the estimated desaturase and elongase activities in the placenta of appropriate (AGA) versus small-for-gestational-age (SGA), and to determine their relationship with the offspring size at birth. Methods: The placental fatty acid profile was analyzed by gas chromatography in 84 infants (45 AGA and 30 SGA) from a prenatal cohort study. The estimated desaturase and elongase activities were calculated from productprecursor fatty acid ratios. Results were associated with maternal (age, body mass index and weight gain during gestation) and neonatal (gestational age, sex, birth weight and birth length) parameters. Results: Differences in placental fatty acid composition between AGA and SGA infants rather than correlations thereof with neonatal parameters were observed. Placentas from SGA infants contained lower levels of omega-3 (ALA, EPA, DPA, and DHA) and high omega-6/omega-3 ratios (AA/DHA and LA/ALA), as well as low elongase (Elovl5) and high desaturase (D9Dn7 and D5Dn6) activity as compared to AGA infants (all p < 0.0001). Discussion: Placentas of AGA and SGA infants differed in fatty acids profile as well as in estimated desaturase and elongase activities. A striking feature of SGA placentas was the low availability of omega-3. Hence, omega-3 fatty acid status deserves further attention, as a potential target of prenatal interventions.This study was supported by grants from the Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III (ISCIII), Madrid, Spain (PI17/ 00557 and PI19/00451 to JB), projects co-funded by FEDER (Fondo Europeo de Desarrollo Regional).Elsevier2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.1016/j.placenta.2021.04.009http://hdl.handle.net/10459.1/72405reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésReproducció del document publicat a https://doi.org/10.1016/j.placenta.2021.04.009Placenta, 2021, vol. 109, p. 4-10cc-by-nc-nd (c) Gómez et al., 2021info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:repositori.udl.cat:10459.1/724052026-06-24T12:42:17Z
dc.title.none.fl_str_mv Fatty acids in the placenta of appropiate- versus small-for-gestational-age infants at term birth
title Fatty acids in the placenta of appropiate- versus small-for-gestational-age infants at term birth
spellingShingle Fatty acids in the placenta of appropiate- versus small-for-gestational-age infants at term birth
Gómez Vilarrubla, Ariadna
Placenta
Fatty acids
SGA
Desaturase and elongase
title_short Fatty acids in the placenta of appropiate- versus small-for-gestational-age infants at term birth
title_full Fatty acids in the placenta of appropiate- versus small-for-gestational-age infants at term birth
title_fullStr Fatty acids in the placenta of appropiate- versus small-for-gestational-age infants at term birth
title_full_unstemmed Fatty acids in the placenta of appropiate- versus small-for-gestational-age infants at term birth
title_sort Fatty acids in the placenta of appropiate- versus small-for-gestational-age infants at term birth
dc.creator.none.fl_str_mv Gómez Vilarrubla, Ariadna
Mas Parés, Berta
Díaz, Marta
Xargay Torrent, Sílvia
Carreras Badosa, Gemma
Jové Font, Mariona
Martín Garí, Meritxell
Bonmatí Santané, Alexandra
Zegher, Francis de
Ibáñez, Lourdes
López Bermejo, Abel
Bassols, Judit
author Gómez Vilarrubla, Ariadna
author_facet Gómez Vilarrubla, Ariadna
Mas Parés, Berta
Díaz, Marta
Xargay Torrent, Sílvia
Carreras Badosa, Gemma
Jové Font, Mariona
Martín Garí, Meritxell
Bonmatí Santané, Alexandra
Zegher, Francis de
Ibáñez, Lourdes
López Bermejo, Abel
Bassols, Judit
author_role author
author2 Mas Parés, Berta
Díaz, Marta
Xargay Torrent, Sílvia
Carreras Badosa, Gemma
Jové Font, Mariona
Martín Garí, Meritxell
Bonmatí Santané, Alexandra
Zegher, Francis de
Ibáñez, Lourdes
López Bermejo, Abel
Bassols, Judit
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Placenta
Fatty acids
SGA
Desaturase and elongase
topic Placenta
Fatty acids
SGA
Desaturase and elongase
description Introduction: Fatty acids are essential nutrients for the fetus and are supplied by the mother through the placenta. Desaturase and elongase enzymes play an important role in modulating the fatty acid composition of body tissues. We aimed to compare the fatty acid profile and the estimated desaturase and elongase activities in the placenta of appropriate (AGA) versus small-for-gestational-age (SGA), and to determine their relationship with the offspring size at birth. Methods: The placental fatty acid profile was analyzed by gas chromatography in 84 infants (45 AGA and 30 SGA) from a prenatal cohort study. The estimated desaturase and elongase activities were calculated from productprecursor fatty acid ratios. Results were associated with maternal (age, body mass index and weight gain during gestation) and neonatal (gestational age, sex, birth weight and birth length) parameters. Results: Differences in placental fatty acid composition between AGA and SGA infants rather than correlations thereof with neonatal parameters were observed. Placentas from SGA infants contained lower levels of omega-3 (ALA, EPA, DPA, and DHA) and high omega-6/omega-3 ratios (AA/DHA and LA/ALA), as well as low elongase (Elovl5) and high desaturase (D9Dn7 and D5Dn6) activity as compared to AGA infants (all p < 0.0001). Discussion: Placentas of AGA and SGA infants differed in fatty acids profile as well as in estimated desaturase and elongase activities. A striking feature of SGA placentas was the low availability of omega-3. Hence, omega-3 fatty acid status deserves further attention, as a potential target of prenatal interventions.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1016/j.placenta.2021.04.009
http://hdl.handle.net/10459.1/72405
url https://doi.org/10.1016/j.placenta.2021.04.009
http://hdl.handle.net/10459.1/72405
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.1016/j.placenta.2021.04.009
Placenta, 2021, vol. 109, p. 4-10
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Gómez et al., 2021
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
rights_invalid_str_mv cc-by-nc-nd (c) Gómez et al., 2021
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
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