Functional interaction between Cdc42 and the stress MAPK signaling pathway during the regulation of fission yeast polarized growth

Cell polarization can be defined as the generation and maintenance of directional cellular organization. The spatial distribution and protein or lipid composition of the cell are not symmetric but organized in specialized domains which allow cells to grow and acquire a certain shape that is closely...

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Detalhes bibliográficos
Autores: Pérez González, Pilar, Soto, Teresa, Gómez Gil, Elisa, Cansado, José
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2019
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/203545
Acesso em linha:http://hdl.handle.net/10261/203545
Access Level:Acceso aberto
Palavra-chave:GTPase
Cdc42
MAPK
Sty1
Polarized growth
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spelling Functional interaction between Cdc42 and the stress MAPK signaling pathway during the regulation of fission yeast polarized growthPérez González, PilarSoto, TeresaGómez Gil, ElisaCansado, JoséGTPaseCdc42MAPKSty1Polarized growthCell polarization can be defined as the generation and maintenance of directional cellular organization. The spatial distribution and protein or lipid composition of the cell are not symmetric but organized in specialized domains which allow cells to grow and acquire a certain shape that is closely linked to their physiological function. The establishment and maintenance of polarized growth requires the coordination of diverse processes including cytoskeletal dynamics, membrane trafficking, and signaling cascade regulation. Some of the major players involved in the selection and maintenance of sites for polarized growth are Rho GTPases, which recognize the polarization site and transmit the signal to regulatory proteins of the cytoskeleton. Additionally, cytoskeletal organization, polarized secretion, and endocytosis are controlled by signaling pathways including those mediated by mitogen-activated protein kinases (MAPKs). Rho GTPases and the MAPK signaling pathways are strongly conserved from yeast to mammals, suggesting that the basic mechanisms of polarized growth have been maintained throughout evolution. For this reason, the study of how polarized growth is established and regulated in simple organisms such as the fission yeast Schizosaccharomyces pombe has contributed to broaden our knowledge about these processes in multicellular organisms. We review here the function of the Cdc42 GTPase and the stress activated MAPK (SAPK) signaling pathways during fission yeast polarized growth, and discuss the relevance of the crosstalk between both pathways.This work was supported by grants BIO2015-69958-P and BFU2017-82423-P from the Ministry of Science, Innovation and Universities (MICIU) and grants CSI068P17 and Escalera de Excelencia CLU-2017-03 from the Regional Government of Castilla y León (JCyL/FEDER) and the European Regional Development Fund (ERDF).Springer NatureMinisterio de Economía y Competitividad (España)Ministerio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Junta de Castilla y LeónEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020192020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/203545reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BIO2015-69958-Pinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/BFU2017-82423-PBFU2017-82423-P/AEI/10.13039/501100011033http://dx.doi.org/10.1007/s10123-019-00072-6Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2035452026-05-22T06:33:51Z
dc.title.none.fl_str_mv Functional interaction between Cdc42 and the stress MAPK signaling pathway during the regulation of fission yeast polarized growth
title Functional interaction between Cdc42 and the stress MAPK signaling pathway during the regulation of fission yeast polarized growth
spellingShingle Functional interaction between Cdc42 and the stress MAPK signaling pathway during the regulation of fission yeast polarized growth
Pérez González, Pilar
GTPase
Cdc42
MAPK
Sty1
Polarized growth
title_short Functional interaction between Cdc42 and the stress MAPK signaling pathway during the regulation of fission yeast polarized growth
title_full Functional interaction between Cdc42 and the stress MAPK signaling pathway during the regulation of fission yeast polarized growth
title_fullStr Functional interaction between Cdc42 and the stress MAPK signaling pathway during the regulation of fission yeast polarized growth
title_full_unstemmed Functional interaction between Cdc42 and the stress MAPK signaling pathway during the regulation of fission yeast polarized growth
title_sort Functional interaction between Cdc42 and the stress MAPK signaling pathway during the regulation of fission yeast polarized growth
dc.creator.none.fl_str_mv Pérez González, Pilar
Soto, Teresa
Gómez Gil, Elisa
Cansado, José
author Pérez González, Pilar
author_facet Pérez González, Pilar
Soto, Teresa
Gómez Gil, Elisa
Cansado, José
author_role author
author2 Soto, Teresa
Gómez Gil, Elisa
Cansado, José
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Junta de Castilla y León
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv GTPase
Cdc42
MAPK
Sty1
Polarized growth
topic GTPase
Cdc42
MAPK
Sty1
Polarized growth
description Cell polarization can be defined as the generation and maintenance of directional cellular organization. The spatial distribution and protein or lipid composition of the cell are not symmetric but organized in specialized domains which allow cells to grow and acquire a certain shape that is closely linked to their physiological function. The establishment and maintenance of polarized growth requires the coordination of diverse processes including cytoskeletal dynamics, membrane trafficking, and signaling cascade regulation. Some of the major players involved in the selection and maintenance of sites for polarized growth are Rho GTPases, which recognize the polarization site and transmit the signal to regulatory proteins of the cytoskeleton. Additionally, cytoskeletal organization, polarized secretion, and endocytosis are controlled by signaling pathways including those mediated by mitogen-activated protein kinases (MAPKs). Rho GTPases and the MAPK signaling pathways are strongly conserved from yeast to mammals, suggesting that the basic mechanisms of polarized growth have been maintained throughout evolution. For this reason, the study of how polarized growth is established and regulated in simple organisms such as the fission yeast Schizosaccharomyces pombe has contributed to broaden our knowledge about these processes in multicellular organisms. We review here the function of the Cdc42 GTPase and the stress activated MAPK (SAPK) signaling pathways during fission yeast polarized growth, and discuss the relevance of the crosstalk between both pathways.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/203545
url http://hdl.handle.net/10261/203545
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BIO2015-69958-P
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/BFU2017-82423-P
BFU2017-82423-P/AEI/10.13039/501100011033
http://dx.doi.org/10.1007/s10123-019-00072-6
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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