Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth–Deferiprone Therapy against Vibrio anguillarum Infection in Fish

Bismuth is a heavy metal with antibacterial properties that has a long history of medicinal use. The results reported here suggest that bismuth(III) (chelated with deferiprone) could be used in aquaculture systems to treat bacterial disease outbreaks, greatly reducing antibiotic use. We tested bismu...

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Detalles Bibliográficos
Autores: Balado Dacosta, Miguel, Rey Varela, Diego, Albela, Ana M., Lemos Ramos, Manuel Luis
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/46348
Acceso en línea:https://hdl.handle.net/10347/46348
Access Level:acceso abierto
Palabra clave:Aquaculture
Bacterial pathogens
Vibriosis
Vibrio anguillarum
Bismuth
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spelling Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth–Deferiprone Therapy against Vibrio anguillarum Infection in FishBalado Dacosta, MiguelRey Varela, DiegoAlbela, Ana M.Lemos Ramos, Manuel LuisAquacultureBacterial pathogensVibriosisVibrio anguillarumBismuthBismuth is a heavy metal with antibacterial properties that has a long history of medicinal use. The results reported here suggest that bismuth(III) (chelated with deferiprone) could be used in aquaculture systems to treat bacterial disease outbreaks, greatly reducing antibiotic use. We tested bismuth susceptibility in a collection of aquaculture bacterial pathogens. In the presence of bismuth concentrations ranging from 1.3 to 13 µM, most bacteria started showing a drastic decrease in their growth ability, although with high inter- and intraspecific variability. The minimal inhibitory concentrations of bismuth ranged from 13 to more than 780 µM, depending on bacterial species and strain. The results of in vivo assays suggest that low concentrations of bismuth could be especially effective to treat vibriosis caused by Vibrio anguillarum, since bismuth greatly reduced mortality in experimentally infected fish without any observable side effects. A bismuth therapy, alone or combined with other antimicrobials, could contribute to reduce the use of antibiotics in aquaculture.MDPIUniversidade de Santiago de Compostela. Instituto de Investigación do Medio Acuático para Unha Saúde Global (iARCUS)Universidade de Santiago de Compostela. Departamento de Microbioloxía e Parasitoloxía20212021-11-2120212021-11-21journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10347/46348reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) licensehttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/463482026-06-15T12:47:27Z
dc.title.none.fl_str_mv Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth–Deferiprone Therapy against Vibrio anguillarum Infection in Fish
title Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth–Deferiprone Therapy against Vibrio anguillarum Infection in Fish
spellingShingle Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth–Deferiprone Therapy against Vibrio anguillarum Infection in Fish
Balado Dacosta, Miguel
Aquaculture
Bacterial pathogens
Vibriosis
Vibrio anguillarum
Bismuth
title_short Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth–Deferiprone Therapy against Vibrio anguillarum Infection in Fish
title_full Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth–Deferiprone Therapy against Vibrio anguillarum Infection in Fish
title_fullStr Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth–Deferiprone Therapy against Vibrio anguillarum Infection in Fish
title_full_unstemmed Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth–Deferiprone Therapy against Vibrio anguillarum Infection in Fish
title_sort Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth–Deferiprone Therapy against Vibrio anguillarum Infection in Fish
dc.creator.none.fl_str_mv Balado Dacosta, Miguel
Rey Varela, Diego
Albela, Ana M.
Lemos Ramos, Manuel Luis
author Balado Dacosta, Miguel
author_facet Balado Dacosta, Miguel
Rey Varela, Diego
Albela, Ana M.
Lemos Ramos, Manuel Luis
author_role author
author2 Rey Varela, Diego
Albela, Ana M.
Lemos Ramos, Manuel Luis
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade de Santiago de Compostela. Instituto de Investigación do Medio Acuático para Unha Saúde Global (iARCUS)
Universidade de Santiago de Compostela. Departamento de Microbioloxía e Parasitoloxía
dc.subject.none.fl_str_mv Aquaculture
Bacterial pathogens
Vibriosis
Vibrio anguillarum
Bismuth
topic Aquaculture
Bacterial pathogens
Vibriosis
Vibrio anguillarum
Bismuth
description Bismuth is a heavy metal with antibacterial properties that has a long history of medicinal use. The results reported here suggest that bismuth(III) (chelated with deferiprone) could be used in aquaculture systems to treat bacterial disease outbreaks, greatly reducing antibiotic use. We tested bismuth susceptibility in a collection of aquaculture bacterial pathogens. In the presence of bismuth concentrations ranging from 1.3 to 13 µM, most bacteria started showing a drastic decrease in their growth ability, although with high inter- and intraspecific variability. The minimal inhibitory concentrations of bismuth ranged from 13 to more than 780 µM, depending on bacterial species and strain. The results of in vivo assays suggest that low concentrations of bismuth could be especially effective to treat vibriosis caused by Vibrio anguillarum, since bismuth greatly reduced mortality in experimentally infected fish without any observable side effects. A bismuth therapy, alone or combined with other antimicrobials, could contribute to reduce the use of antibiotics in aquaculture.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-11-21
2021
2021-11-21
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10347/46348
url https://hdl.handle.net/10347/46348
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
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