Effect of a Very-Low-Calorie Ketogenic Diet on Circulating Myokine Levels Compared with the Effect of Bariatric Surgery or a Low-Calorie Diet in Patients with Obesity

: The preservation of muscle mass and muscle function after weight loss therapy is currently a considerable challenge in the fight against obesity. Muscle mass secretes proteins called myokines that have relevant functions in the regulation of metabolism and health. This study was aimed to evaluate...

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Autores: Sajoux ., Ignacio, Sajoux, I., Lorenzo, P. M., Gomez-Arbelaez, D., Zulet, M. A., Abete, I., Castro, A. I., BALTAR BOILEVE, JAVIER, Portillo, M. P., Tinahones, F. J., Martinez, J. A., Crujeiras Martínez, Ana Belén, CASANUEVA FREIJO, FELIPE
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Servizo Galego de Saúde (SERGAS)
Repositorio:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/15544
Acceso en línea:https://www.ncbi.nlm.nih.gov/pubmed/31590286
http://hdl.handle.net/20.500.11940/15544
Access Level:acceso abierto
Palabra clave:CHUS
IDIS
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spelling Effect of a Very-Low-Calorie Ketogenic Diet on Circulating Myokine Levels Compared with the Effect of Bariatric Surgery or a Low-Calorie Diet in Patients with ObesitySajoux ., IgnacioSajoux, I.Lorenzo, P. M.Gomez-Arbelaez, D.Zulet, M. A.Abete, I.Castro, A. I.BALTAR BOILEVE, JAVIERPortillo, M. P.Tinahones, F. J.Martinez, J. A.Crujeiras Martínez, Ana BelénCASANUEVA FREIJO, FELIPECHUSIDIS: The preservation of muscle mass and muscle function after weight loss therapy is currently a considerable challenge in the fight against obesity. Muscle mass secretes proteins called myokines that have relevant functions in the regulation of metabolism and health. This study was aimed to evaluate whether a very low-calorie ketogenic (VLCK) diet may modulate myokine levels, in addition to changes in body composition, compared to a standard, balanced low-calorie (LC) diet or bariatric surgery in patients with obesity. Body composition, ketosis, insulin sensitivity and myokines were evaluated in 79 patients with overweight/obesity after a therapy to lose weight with a VLCK diet, a LC diet or bariatric surgery. The follow-up was 6 months. The weight loss therapies induced changes in myokine levels in association with changes in body composition and biochemical parameters. The effects on circulating myokine levels compared to those at baseline were stronger after the VLCK diet than LC diet or bariatric surgery. Differences reached statistical significance for IL-8, MMP2 and irisin. In conclusion, nutritional interventions or bariatric surgery to lose weight induces changes in circulating myokine levels, being this effect potentially most notable after following a VLCK diet.2019info:eu-repo/semantics/articlehttps://www.ncbi.nlm.nih.gov/pubmed/31590286http://hdl.handle.net/20.500.11940/15544reponame:RUNA. Repositorio da Consellería de Sanidade e Sergasinstname:Servizo Galego de Saúde (SERGAS)http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:runa.sergas.gal:20.500.11940/155442026-06-12T08:40:47Z
dc.title.none.fl_str_mv Effect of a Very-Low-Calorie Ketogenic Diet on Circulating Myokine Levels Compared with the Effect of Bariatric Surgery or a Low-Calorie Diet in Patients with Obesity
title Effect of a Very-Low-Calorie Ketogenic Diet on Circulating Myokine Levels Compared with the Effect of Bariatric Surgery or a Low-Calorie Diet in Patients with Obesity
spellingShingle Effect of a Very-Low-Calorie Ketogenic Diet on Circulating Myokine Levels Compared with the Effect of Bariatric Surgery or a Low-Calorie Diet in Patients with Obesity
Sajoux ., Ignacio
CHUS
IDIS
title_short Effect of a Very-Low-Calorie Ketogenic Diet on Circulating Myokine Levels Compared with the Effect of Bariatric Surgery or a Low-Calorie Diet in Patients with Obesity
title_full Effect of a Very-Low-Calorie Ketogenic Diet on Circulating Myokine Levels Compared with the Effect of Bariatric Surgery or a Low-Calorie Diet in Patients with Obesity
title_fullStr Effect of a Very-Low-Calorie Ketogenic Diet on Circulating Myokine Levels Compared with the Effect of Bariatric Surgery or a Low-Calorie Diet in Patients with Obesity
title_full_unstemmed Effect of a Very-Low-Calorie Ketogenic Diet on Circulating Myokine Levels Compared with the Effect of Bariatric Surgery or a Low-Calorie Diet in Patients with Obesity
title_sort Effect of a Very-Low-Calorie Ketogenic Diet on Circulating Myokine Levels Compared with the Effect of Bariatric Surgery or a Low-Calorie Diet in Patients with Obesity
dc.creator.none.fl_str_mv Sajoux ., Ignacio
Sajoux, I.
Lorenzo, P. M.
Gomez-Arbelaez, D.
Zulet, M. A.
Abete, I.
Castro, A. I.
BALTAR BOILEVE, JAVIER
Portillo, M. P.
Tinahones, F. J.
Martinez, J. A.
Crujeiras Martínez, Ana Belén
CASANUEVA FREIJO, FELIPE
author Sajoux ., Ignacio
author_facet Sajoux ., Ignacio
Sajoux, I.
Lorenzo, P. M.
Gomez-Arbelaez, D.
Zulet, M. A.
Abete, I.
Castro, A. I.
BALTAR BOILEVE, JAVIER
Portillo, M. P.
Tinahones, F. J.
Martinez, J. A.
Crujeiras Martínez, Ana Belén
CASANUEVA FREIJO, FELIPE
author_role author
author2 Sajoux, I.
Lorenzo, P. M.
Gomez-Arbelaez, D.
Zulet, M. A.
Abete, I.
Castro, A. I.
BALTAR BOILEVE, JAVIER
Portillo, M. P.
Tinahones, F. J.
Martinez, J. A.
Crujeiras Martínez, Ana Belén
CASANUEVA FREIJO, FELIPE
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CHUS
IDIS
topic CHUS
IDIS
description : The preservation of muscle mass and muscle function after weight loss therapy is currently a considerable challenge in the fight against obesity. Muscle mass secretes proteins called myokines that have relevant functions in the regulation of metabolism and health. This study was aimed to evaluate whether a very low-calorie ketogenic (VLCK) diet may modulate myokine levels, in addition to changes in body composition, compared to a standard, balanced low-calorie (LC) diet or bariatric surgery in patients with obesity. Body composition, ketosis, insulin sensitivity and myokines were evaluated in 79 patients with overweight/obesity after a therapy to lose weight with a VLCK diet, a LC diet or bariatric surgery. The follow-up was 6 months. The weight loss therapies induced changes in myokine levels in association with changes in body composition and biochemical parameters. The effects on circulating myokine levels compared to those at baseline were stronger after the VLCK diet than LC diet or bariatric surgery. Differences reached statistical significance for IL-8, MMP2 and irisin. In conclusion, nutritional interventions or bariatric surgery to lose weight induces changes in circulating myokine levels, being this effect potentially most notable after following a VLCK diet.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://www.ncbi.nlm.nih.gov/pubmed/31590286
http://hdl.handle.net/20.500.11940/15544
url https://www.ncbi.nlm.nih.gov/pubmed/31590286
http://hdl.handle.net/20.500.11940/15544
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:RUNA. Repositorio da Consellería de Sanidade e Sergas
instname:Servizo Galego de Saúde (SERGAS)
instname_str Servizo Galego de Saúde (SERGAS)
reponame_str RUNA. Repositorio da Consellería de Sanidade e Sergas
collection RUNA. Repositorio da Consellería de Sanidade e Sergas
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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