Fattening lambs with divergent residual feed intakes and weight gains: Unravelling mechanisms driving feed efficiency

9 páginas, 5 tablas.

Detalles Bibliográficos
Autores: Giráldez, Francisco Javier, Santos Antón, Nuria, Santos Baza, Alba, Valdés, Carmen, López, Secundino, Andrés, Sonia
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/243889
Acceso en línea:http://hdl.handle.net/10261/243889
Access Level:acceso abierto
Palabra clave:Feed efficiency
Lamb
Residual feed intake
Cholesterol
Inflammation
Insulin
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spelling Fattening lambs with divergent residual feed intakes and weight gains: Unravelling mechanisms driving feed efficiencyGiráldez, Francisco JavierSantos Antón, NuriaSantos Baza, AlbaValdés, CarmenLópez, SecundinoAndrés, SoniaFeed efficiencyLambResidual feed intakeCholesterolInflammationInsulin9 páginas, 5 tablas.Important achievements have been made to improve feed efficiency of farm livestock, but molecular mechanisms determining feed utilization remain unclear. The objective of this work was to identify the reasons behind divergent feed efficiencies in fattening lambs. Twenty newborn male Assaf lambs were fed milk replacer (MR) ad libitum using an automatic feeder, and weaned progressively during the last 7 days of the artificial suckling period (50 days in total). Then, all the lambs were offered ad libitum a complete pelleted diet during the fattening phase. During the fattening period, lambs were weighed twice weekly and daily dry matter intake was measured. These data were used to estimate residual feed intake (RFI), residual weight gain (RWG), and residual intake and body weight gain (RIG). Animals were ranked according to RIG, and then assigned to two experimental groups (n = 10 per treatment): group EFFI including the most efficient lambs (with negative values for RIG) and group NEFFI with the least efficient lambs (positive values for RIG). The most relevant results revealed that divergent values for feed efficiency traits in these fattening lambs were not associated to differences in digestibility or ruminal fermentation parameters (P > 0.05). However, the NEFFI lambs presented lower concentration of glucose (95.4 vs. 88.2 mg/dL; P < 0.05) and cholesterol (62.8 vs. 55.1 mg/dL; P < 0.05) in the serum. These effects might be related to the lower gene expression of enzymes involved in key metabolic pathways in the liver (e.g., PDHA1OA, CYP3A4). Moreover, bone formation and growth in NEFFI lambs also might have been compromised by a lower expression of genes involved in protein synthesis, such as those encoding ribosomal proteins (e.g., RPL22L1), these results being aligned with the lower albumin concentration also observed in the serum of these animals (35.56 vs. 33.89 g/L; P < 0.05). A pro-inflammatory profile at both locations, liver and ileum, having the last one a down regulation of genes encoding anti-inflammatory cytokines involved in the innate immune response (e.g., IL-4 and TGF-β) can also explain, at least partially, an increased expenditure of energy and protein redirected from growth and protein accretion towards the alleviation of systemic inflammation.This work was funded by the Spanish Ministry of Research, Innovation and Universities (RTI2018−099329-B-I00, MCIU/AEI/FEDER, EU). Alba Santos gratefully acknowledges receipt of a pre-doctoral grant from the Spanish Ministry of Education, Culture, and Sport (MECD, FPU15/01630).Elsevier BVMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)European CommissionGiráldez, Francisco Javier [0000-0002-0680-1541]Santos Baza, Alba [0000-0002-4962-2623]Valdés, Carmen [0000-0003-3581-164X]López, Secundino [0000-0001-6267-683X]Andrés, Sonia [0000-0001-5255-1582]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120212021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/243889reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018−099329-B-I00http://dx.doi.org/10.1016/j.anifeedsci.2021.114821Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2438892026-05-22T06:33:51Z
dc.title.none.fl_str_mv Fattening lambs with divergent residual feed intakes and weight gains: Unravelling mechanisms driving feed efficiency
title Fattening lambs with divergent residual feed intakes and weight gains: Unravelling mechanisms driving feed efficiency
spellingShingle Fattening lambs with divergent residual feed intakes and weight gains: Unravelling mechanisms driving feed efficiency
Giráldez, Francisco Javier
Feed efficiency
Lamb
Residual feed intake
Cholesterol
Inflammation
Insulin
title_short Fattening lambs with divergent residual feed intakes and weight gains: Unravelling mechanisms driving feed efficiency
title_full Fattening lambs with divergent residual feed intakes and weight gains: Unravelling mechanisms driving feed efficiency
title_fullStr Fattening lambs with divergent residual feed intakes and weight gains: Unravelling mechanisms driving feed efficiency
title_full_unstemmed Fattening lambs with divergent residual feed intakes and weight gains: Unravelling mechanisms driving feed efficiency
title_sort Fattening lambs with divergent residual feed intakes and weight gains: Unravelling mechanisms driving feed efficiency
dc.creator.none.fl_str_mv Giráldez, Francisco Javier
Santos Antón, Nuria
Santos Baza, Alba
Valdés, Carmen
López, Secundino
Andrés, Sonia
author Giráldez, Francisco Javier
author_facet Giráldez, Francisco Javier
Santos Antón, Nuria
Santos Baza, Alba
Valdés, Carmen
López, Secundino
Andrés, Sonia
author_role author
author2 Santos Antón, Nuria
Santos Baza, Alba
Valdés, Carmen
López, Secundino
Andrés, Sonia
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
European Commission
Giráldez, Francisco Javier [0000-0002-0680-1541]
Santos Baza, Alba [0000-0002-4962-2623]
Valdés, Carmen [0000-0003-3581-164X]
López, Secundino [0000-0001-6267-683X]
Andrés, Sonia [0000-0001-5255-1582]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Feed efficiency
Lamb
Residual feed intake
Cholesterol
Inflammation
Insulin
topic Feed efficiency
Lamb
Residual feed intake
Cholesterol
Inflammation
Insulin
description 9 páginas, 5 tablas.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/243889
url http://hdl.handle.net/10261/243889
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018−099329-B-I00
http://dx.doi.org/10.1016/j.anifeedsci.2021.114821
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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