Different HCV Exposure Drives Specific miRNA Profile in PBMCs of HIV Patients
18 Pág. Departamento de Mejora Genética Animal
| Autores: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/284293 |
| Acceso en línea: | http://hdl.handle.net/10261/284293 https://api.elsevier.com/content/abstract/scopus_id/85119590651 |
| Access Level: | acceso abierto |
| Palabra clave: | HCV HIV High throughput sequence MicroRNAs Spontaneous viral clearance |
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Different HCV Exposure Drives Specific miRNA Profile in PBMCs of HIV Patients |
| title |
Different HCV Exposure Drives Specific miRNA Profile in PBMCs of HIV Patients |
| spellingShingle |
Different HCV Exposure Drives Specific miRNA Profile in PBMCs of HIV Patients Valle-Millares, Daniel HCV HIV High throughput sequence MicroRNAs Spontaneous viral clearance |
| title_short |
Different HCV Exposure Drives Specific miRNA Profile in PBMCs of HIV Patients |
| title_full |
Different HCV Exposure Drives Specific miRNA Profile in PBMCs of HIV Patients |
| title_fullStr |
Different HCV Exposure Drives Specific miRNA Profile in PBMCs of HIV Patients |
| title_full_unstemmed |
Different HCV Exposure Drives Specific miRNA Profile in PBMCs of HIV Patients |
| title_sort |
Different HCV Exposure Drives Specific miRNA Profile in PBMCs of HIV Patients |
| dc.creator.none.fl_str_mv |
Valle-Millares, Daniel Brochado-Kith, Óscar Martín-Carbonero, Luz Domínguez-Domínguez, Lourdes Ryan, Pablo De Los Santos, Ignacio De la Fuente, Sara Castro, Juan M. Lagarde, María Cuevas, G. Mayoral-Muñoz, Mario Matarranz, Mariano Díez, Victorino Gómez-Sanz, Alicia Martínez-Román, Paula Crespo-Bermejo, Celia Palladino, Claudia Muñoz Muñoz, María Jiménez-Sousa, María Angeles Resino, Salvador Briz, Verónica Fernández-Rodríguez, Amanda |
| author |
Valle-Millares, Daniel |
| author_facet |
Valle-Millares, Daniel Brochado-Kith, Óscar Martín-Carbonero, Luz Domínguez-Domínguez, Lourdes Ryan, Pablo De Los Santos, Ignacio De la Fuente, Sara Castro, Juan M. Lagarde, María Cuevas, G. Mayoral-Muñoz, Mario Matarranz, Mariano Díez, Victorino Gómez-Sanz, Alicia Martínez-Román, Paula Crespo-Bermejo, Celia Palladino, Claudia Muñoz Muñoz, María Jiménez-Sousa, María Angeles Resino, Salvador Briz, Verónica Fernández-Rodríguez, Amanda |
| author_role |
author |
| author2 |
Brochado-Kith, Óscar Martín-Carbonero, Luz Domínguez-Domínguez, Lourdes Ryan, Pablo De Los Santos, Ignacio De la Fuente, Sara Castro, Juan M. Lagarde, María Cuevas, G. Mayoral-Muñoz, Mario Matarranz, Mariano Díez, Victorino Gómez-Sanz, Alicia Martínez-Román, Paula Crespo-Bermejo, Celia Palladino, Claudia Muñoz Muñoz, María Jiménez-Sousa, María Angeles Resino, Salvador Briz, Verónica Fernández-Rodríguez, Amanda |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto de Salud Carlos III Universidad Alfonso X El Sabio Red Española de Investigación en SIDA Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España) Valle-Millares, Daniel [0000-0002-5205-855X] Brochado-Kith, Óscar [0000-0001-8372-2604] Martín-Carbonero, Luz [0000-0001-8102-4079] Domínguez-Domínguez, Lourdes [0000-0001-6018-9026] Ryan, Pablo [0000-0002-4212-7419] De Los Santos, Ignacio [0000-0001-7073-5211] Lagarde, María [0000-0002-7712-6977] Cuevas, G. [0000-0001-7875-6359] Matarranz, Mariano [0000-0002-6120-7545] Díez, Victorino [0000-0003-1679-133X] Gómez-Sanz, Alicia [0000-0003-4674-3005] Crespo-Bermejo, Celia [0000-0002-2813-2481] Palladino, Claudia [0000-0002-8148-0928] Muñoz Muñoz, María [0000-0001-7875-6359] Jiménez-Sousa, María Angeles [0000-0002-1945-6169] Resino, Salvador [0000-0001-8783-0450] Briz, Verónica [0000-0003-2297-5098] Fernández-Rodríguez, Amanda [0000-0002-5110-2213] Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
HCV HIV High throughput sequence MicroRNAs Spontaneous viral clearance |
| topic |
HCV HIV High throughput sequence MicroRNAs Spontaneous viral clearance |
| description |
18 Pág. Departamento de Mejora Genética Animal |
| publishDate |
2021 |
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2021 2022 2022 |
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info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10261/284293 https://api.elsevier.com/content/abstract/scopus_id/85119590651 |
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http://hdl.handle.net/10261/284293 https://api.elsevier.com/content/abstract/scopus_id/85119590651 |
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Inglés |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Multidisciplinary Digital Publishing Institute |
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Multidisciplinary Digital Publishing Institute |
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Different HCV Exposure Drives Specific miRNA Profile in PBMCs of HIV PatientsValle-Millares, DanielBrochado-Kith, ÓscarMartín-Carbonero, LuzDomínguez-Domínguez, LourdesRyan, PabloDe Los Santos, IgnacioDe la Fuente, SaraCastro, Juan M.Lagarde, MaríaCuevas, G.Mayoral-Muñoz, MarioMatarranz, MarianoDíez, VictorinoGómez-Sanz, AliciaMartínez-Román, PaulaCrespo-Bermejo, CeliaPalladino, ClaudiaMuñoz Muñoz, MaríaJiménez-Sousa, María AngelesResino, SalvadorBriz, VerónicaFernández-Rodríguez, AmandaHCVHIVHigh throughput sequenceMicroRNAsSpontaneous viral clearance18 Pág. Departamento de Mejora Genética AnimalMicro RNAs (miRNAs) are essential players in HIV and HCV infections, as both viruses modulate cellular miRNAs and interact with the miRNA-mediated host response. We aim to analyze the miRNA profile of HIV patients with different exposure to HCV to explore specific signatures in the miRNA profile of PBMCs for each type of infection. We massively sequenced small RNAs of PBMCs from 117 HIV+ infected patients: 45 HIV+ patients chronically infected with HCV (HIV/HCV+), 36 HIV+ that spontaneously clarified HCV after acute infection (HIV/HCV-) and 36 HIV+ patients without previous HCV infection (HIV). Thirty-two healthy patients were used as healthy controls (HC). Differential expression analysis showed significantly differentially expressed (SDE) miRNAs in HIV/HCV+ (n = 153), HIV/HCV- (n = 169) and HIV (n = 153) patients. We found putative dysregulated pathways, such as infectious-related and PI3K signaling pathways, common in all contrasts. Specifically, putatively targeted genes involved in antifolate resistance (HIV/HV+), cancer-related pathways (HIV/HCV-) and HIF-signaling (HIV) were identified, among others. Our findings revealed that HCV strongly influences the expression profile of PBMCs from HIV patients through the disruption of its miRNome. Thus, different HCV exposure can be identified by specific miRNA signatures in PBMCs.This work has been supported by grants from Institute of Health Carlos III, [PI15CIII/00031 and PI18CIII/00020/ to AFR and VB] and the Foundation Universidad Alfonso X el Sabio-Santander [grant number 1.010.932 to AFR] and the Spanish AIDS Research Network (RD16CIII/0002/0002), and Centro de Investigación Biomédica en Red (CIBER) en Enfermedades Infecciosas (CB21/13/00044). AFR is supported by the Miguel Servet programme from Fondo de Investigación Sanitaria (ISCIII) [CP14/CIII/00010 and CPII20CIII/0001]Peer reviewedMultidisciplinary Digital Publishing InstituteInstituto de Salud Carlos IIIUniversidad Alfonso X El SabioRed Española de Investigación en SIDACentro de Investigación Biomédica en Red de Enfermedades Infecciosas (España)Valle-Millares, Daniel [0000-0002-5205-855X]Brochado-Kith, Óscar [0000-0001-8372-2604]Martín-Carbonero, Luz [0000-0001-8102-4079]Domínguez-Domínguez, Lourdes [0000-0001-6018-9026]Ryan, Pablo [0000-0002-4212-7419]De Los Santos, Ignacio [0000-0001-7073-5211]Lagarde, María [0000-0002-7712-6977]Cuevas, G. [0000-0001-7875-6359]Matarranz, Mariano [0000-0002-6120-7545]Díez, Victorino [0000-0003-1679-133X]Gómez-Sanz, Alicia [0000-0003-4674-3005]Crespo-Bermejo, Celia [0000-0002-2813-2481]Palladino, Claudia [0000-0002-8148-0928]Muñoz Muñoz, María [0000-0001-7875-6359]Jiménez-Sousa, María Angeles [0000-0002-1945-6169]Resino, Salvador [0000-0001-8783-0450]Briz, Verónica [0000-0003-2297-5098]Fernández-Rodríguez, Amanda [0000-0002-5110-2213]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/284293https://api.elsevier.com/content/abstract/scopus_id/85119590651reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MICINN//PI15CIIIinfo:eu-repo/grantAgreement/MICINN//PI18CIIIinfo:eu-repo/grantAgreement/MICINN//CB21info:eu-repo/grantAgreement/MICINN//CP14info:eu-repo/grantAgreement/MICINN//CPII20CIIIBiomedicineshttps://doi.org/10.3390/biomedicines9111627Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2842932026-05-22T06:33:51Z |
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