Abnormal orbitofrontal development due to prematurity

Objective: To investigate the effects of prematurity on sulcal formation. Methods: We evaluated the depth and volume of the primary olfactory sulcus (developed at 16 weeks' gestation) and the secondary orbital sulci (which start to develop at 28 weeks' gestation) in a sample of 22 adolesce...

Descripción completa

Detalles Bibliográficos
Autores: Giménez Navarro, Mónica, Junqué i Plaja, Carme, 1955-, Vendrell i Gómez, Pere, Narberhaus, Ana, Bargalló Alabart, Núria, Botet Mussons, Francisco, Mercader Sobrequés, José Ma.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2006
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/223458
Acceso en línea:https://hdl.handle.net/2445/223458
Access Level:acceso abierto
Palabra clave:Neurologia dels nadons
Infants prematurs
Malformacions
Crani
Neonatal neurology
Premature infants
Human abnormalities
Skull
id ES_4531ac7c937bd2aab43c8a73c4dc4bda
oai_identifier_str oai:diposit.ub.edu:2445/223458
network_acronym_str ES
network_name_str España
repository_id_str
spelling Abnormal orbitofrontal development due to prematurityGiménez Navarro, MónicaJunqué i Plaja, Carme, 1955-Vendrell i Gómez, PereNarberhaus, AnaBargalló Alabart, NúriaBotet Mussons, FranciscoMercader Sobrequés, José Ma.Neurologia dels nadonsInfants prematursMalformacionsCraniNeonatal neurologyPremature infantsHuman abnormalitiesSkullObjective: To investigate the effects of prematurity on sulcal formation. Methods: We evaluated the depth and volume of the primary olfactory sulcus (developed at 16 weeks' gestation) and the secondary orbital sulci (which start to develop at 28 weeks' gestation) in a sample of 22 adolescents with history of very-preterm birth (VPTB). We compared this preterm sample with a sample of subjects born at term and matched by age, gender, and sociocultural status. The Anatomist/BrainVISA 3.0.1 package was used to identify and quantify the sulci. In addition, voxel-based morphometry (VBM) was used to analyze possible reductions of gray and white matter in the orbitofrontal area. Results: Compared with controls, we found a significant reduction in the secondary sulci depth but not in the primary sulcus in the VPTB. VBM analysis showed reduced gray-matter volume in VPTB in the orbital region. Conclusions: Premature birth affects cerebral gyrification, and this impairment is not reversible during childhood. Identification of the specific factors involved in abnormal brain maturation may lead to effective interventions.Lippincott, Williams & Wilkins. Wolters Kluwer Health2006info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/223458Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1212/01.wnl.0000244485.51898.93Neurology, 2006, vol. 67, num.10, p. 1818-1822https://doi.org/10.1212/01.wnl.0000244485.51898.93(c) American Academy of Neurology, 2006info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2234582026-05-27T06:46:51Z
dc.title.none.fl_str_mv Abnormal orbitofrontal development due to prematurity
title Abnormal orbitofrontal development due to prematurity
spellingShingle Abnormal orbitofrontal development due to prematurity
Giménez Navarro, Mónica
Neurologia dels nadons
Infants prematurs
Malformacions
Crani
Neonatal neurology
Premature infants
Human abnormalities
Skull
title_short Abnormal orbitofrontal development due to prematurity
title_full Abnormal orbitofrontal development due to prematurity
title_fullStr Abnormal orbitofrontal development due to prematurity
title_full_unstemmed Abnormal orbitofrontal development due to prematurity
title_sort Abnormal orbitofrontal development due to prematurity
dc.creator.none.fl_str_mv Giménez Navarro, Mónica
Junqué i Plaja, Carme, 1955-
Vendrell i Gómez, Pere
Narberhaus, Ana
Bargalló Alabart, Núria
Botet Mussons, Francisco
Mercader Sobrequés, José Ma.
author Giménez Navarro, Mónica
author_facet Giménez Navarro, Mónica
Junqué i Plaja, Carme, 1955-
Vendrell i Gómez, Pere
Narberhaus, Ana
Bargalló Alabart, Núria
Botet Mussons, Francisco
Mercader Sobrequés, José Ma.
author_role author
author2 Junqué i Plaja, Carme, 1955-
Vendrell i Gómez, Pere
Narberhaus, Ana
Bargalló Alabart, Núria
Botet Mussons, Francisco
Mercader Sobrequés, José Ma.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Neurologia dels nadons
Infants prematurs
Malformacions
Crani
Neonatal neurology
Premature infants
Human abnormalities
Skull
topic Neurologia dels nadons
Infants prematurs
Malformacions
Crani
Neonatal neurology
Premature infants
Human abnormalities
Skull
description Objective: To investigate the effects of prematurity on sulcal formation. Methods: We evaluated the depth and volume of the primary olfactory sulcus (developed at 16 weeks' gestation) and the secondary orbital sulci (which start to develop at 28 weeks' gestation) in a sample of 22 adolescents with history of very-preterm birth (VPTB). We compared this preterm sample with a sample of subjects born at term and matched by age, gender, and sociocultural status. The Anatomist/BrainVISA 3.0.1 package was used to identify and quantify the sulci. In addition, voxel-based morphometry (VBM) was used to analyze possible reductions of gray and white matter in the orbitofrontal area. Results: Compared with controls, we found a significant reduction in the secondary sulci depth but not in the primary sulcus in the VPTB. VBM analysis showed reduced gray-matter volume in VPTB in the orbital region. Conclusions: Premature birth affects cerebral gyrification, and this impairment is not reversible during childhood. Identification of the specific factors involved in abnormal brain maturation may lead to effective interventions.
publishDate 2006
dc.date.none.fl_str_mv 2006
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/223458
url https://hdl.handle.net/2445/223458
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1212/01.wnl.0000244485.51898.93
Neurology, 2006, vol. 67, num.10, p. 1818-1822
https://doi.org/10.1212/01.wnl.0000244485.51898.93
dc.rights.none.fl_str_mv (c) American Academy of Neurology, 2006
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) American Academy of Neurology, 2006
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Lippincott, Williams & Wilkins. Wolters Kluwer Health
publisher.none.fl_str_mv Lippincott, Williams & Wilkins. Wolters Kluwer Health
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869407145016950784
score 15.812429

Similares en LA Referencia